A5063567724- Meningioma and schwannoma management
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Neurofibromatosis and Schwannoma Cases
- Substance Abuse Treatment and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Homelessness and Social Issues
- Facial Nerve Paralysis Treatment and Research
- Crime Patterns and Interventions
- Ear and Head Tumors
- Vestibular and auditory disorders
- Adrenal and Paraganglionic Tumors
- Cannabis and Cannabinoid Research
- Bone Tumor Diagnosis and Treatments
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Nasal Surgery and Airway Studies
- Elder Abuse and Neglect
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Intimate Partner and Family Violence
- Neurosurgical Procedures and Complications
Cambridge University Hospitals NHS Foundation Trust
2016-2025
University of Cambridge
2015-2025
Addenbrooke's Hospital
2013-2024
Bridge University
2016-2022
St Thomas' Hospital
2007-2019
Cochlear (Australia)
2018
Cochlear (France)
2018
Texas Neurofibromatosis Foundation
2018
Laboratoire Plasticité du Cerveau
2018
Manchester Royal Infirmary
2018
To assess the impact on image quality of MRI without magnet removal in cochlear implant (CI) and auditory brainstem (ABI) users with neurofibromatosis type 2 (NF2).Prospective cohort.Tertiary center for implantation.Thirteen patients (10 ABI, 3CI) NF2 underwent a total 76 scans.MRI removal.Ability to visualize ipsilateral contralateral cerebellopontine angles (CPAs) internal meati (IAM) head MRI.Of scans, 40 were head, 28 spine 8 other regions. Scanning was performed tight bandage plastic...
Objective We report our experience of functional imaging with 11 C-methionine positron emission tomography–computed tomography (PET–CT) co-registered 3D gradient echo (spoiled recalled (SPGR)) magnetic resonance (MRI) in the investigation ACTH-dependent Cushing's syndrome. Design Twenty patients i) de novo disease (CD, n =10), ii) residual or recurrent hypercortisolism following first pituitary surgery (±radiotherapy; =8) iii) ectopic syndrome ( =2) were referred to centre for studies...
Background and aims Eustachian tube dysfunction (ETD) is a commonly diagnosed disorder of opening closure, which may be associated with severe symptoms middle ear disease. Currently the diagnosis obstructive patulous forms ETD primarily based on non-specific or examination findings, rather than measurement underlying function tube. This has proved problematic when selecting patients for treatment, designing trial inclusion criteria outcomes. study to determine correlation diagnostic value...
Abstract Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from centers suggest safety despite apparent radiation-associated malignancy being reported. We determined whether radiation NF2-related schwannomatosis patients associated with increased rates subsequent (M)/malignant progression (MP). Methods All UK NF2 were eligible if they had a clinical/molecular diagnosis. Cases treated for tumors. Controls matched...
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction loss sensory cells from vestibular epithelia inner ear. However, inaccessibility ear tissue humans severely restricts possibilities for experimental manipulation develop therapies ameliorate this loss. We provide structural and functional analysis human harvested at trans-labyrinthine surgery. demonstrate viability labeling with specific markers hair cell function ion...
Objective To determine if functional imaging using 11 C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. Design/methods Twenty-six patients persistent acromegaly after previous treatment, whom appearances were considered indeterminate, referred our centre for evaluation over a 4.5-year period....
The current study aimed to model the effect of Australia's first Medically Supervised Injecting Centre (MSIC) on acquisitive crime and loitering by drug users dealers. MSIC drug-related property violent was examined conducting time series analysis police-recorded trends in theft robbery incidents, respectively. use dealing (a) a special proxy measure loitering; (b) interviewing key informants; (c) examining proportion Sydney offences that were recorded Kings Cross. There no evidence trial...
Abstract Objectives: To review our experience of cochlear implant failure and subsequent revision surgery, to illustrate the we have gained by presenting a series lessons learned. Methods: A combined retrospective prospective study surgery in UK regional centre. Results: Of 746 implantations undertaken, 33 (4.7 per cent adults 4.1 children) had registered requiring re-implantation. The mean time device was 60 months 35 children. Causes were medical ( n = 11), electrode displacement 2), ‘hard...
Accurate and precise measurement of vestibular schwannoma (VS) size is key to clinical management decisions. Linear measurements are used in routine practice but prone error. This study aims compare a semi-automated volume segmentation tool against standard linear method for measuring small VS. also examines whether oblique tumour orientation can contribute Experimental comparison observer agreement using two techniques. Tertiary skull base unit. Twenty-four patients with unilateral sporadic...
Objective To review the treatment of squamous carcinoma temporal bone at a regional skull base unit for period 1982–2012. Study Design Retrospective case review. Setting Tertiary referral center. Patients Sixty patients with primary bone. Interventions Multidisciplinary team approach including surgical resection, reconstruction, and postoperative radiotherapy. Main Outcome Measures Disease-specific survival, overall survival. Results The 5-year disease-specific survival whole cohort was 44%...
Objective To examine the quality of information provided by artificial intelligence platforms ChatGPT-4 and Claude 2 surrounding management vestibular schwannomas. Study design Cross-sectional. Setting Skull base surgeons were involved from different centers countries. Intervention Thirty-six questions regarding schwannoma tested. Artificial responses subsequently evaluated 19 lateral skull using Quality Assessment Medical Intelligence (QAMAI) questionnaire, assessing “Accuracy,” “Clarity,”...
In 1987 the Cannabis Expiration Notice scheme decreased penalties for personal use of cannabis in South Australia. Data from four National Campaign Against Drug Abuse (NCADA) household drug-use surveys covering period 1985 to 1993 were analysed measure effect decriminalisation on use. The main outcomes used self-reported prevalence rates having ever and current weekly Logistic regression was control potentially confounding effects age sex. Other been offered willingness if it. Between...
Rehabilitation of hearing is complicated in patients with profound bilateral loss the presence sporadic vestibular schwannoma (VS) or neurofibromatosis 2 (NF2), especially if tumor does not need to be removed. We present outcome who have had a cochlear implant affected ear without removal primary tumor.This retrospective multicentre study investigating outcomes implantation profoundly deaf implanted ear.Out 11 patients, 5 required no treatment for their tumor, whereas 6 previously undergone...
Objectives To report our approach to the surgical management of vestibular schwannomas (VSs) and hearing rehabilitation in neurofibromatosis Type 2 (NF2). Design Retrospective cohort study. Setting Tertiary referral NF2 unit. Patients Between 1981 2011, seventy-five patients were managed unit, which, 58 are under current review. Main Outcome Measures who underwent VS excision evaluated for tumor size, approach, outcomes facial nerve function. All mutation, hearing, auditory implantation...
Objective: To assess the complication rate of magnetic resonance imaging (MRI) using 1.5 T scanners on cochlear implant (CI) and auditory brainstem (ABI) recipients over 14.5 years. Methods: Prospective study conducted in a tertiary referral center for implantation, including patients with neurofibromatosis 2. The primary outcome was complications related to MRI scanning recipients, failure complete sessions. secondary magnet void size due situ. Results: Ninety-seven (21 ABI 76 CI whom 23...
CRANIAL (CSF Rhinorrhoea After Endonasal Intervention to the Skull Base) is a prospective multicenter observational study seeking determine 1) scope of skull base repair methods used and 2) corresponding rates postoperative cerebrospinal fluid (CSF) rhinorrhea in endonasal transsphenoidal approach (TSA) expanded (EEA) for tumors. We sought pilot project, assessing feasibility acceptability by gathering preliminary data. A cohort was piloted at 12 tertiary neurosurgical units United Kingdom....
To estimate the prevalence of, and risk factors associated with electrode migration (EM) in cochlear implant (CI) recipients.Historical cohort study of all CIs performed between 1 January 2018 August 2021 a single tertiary adult paediatric CI centre UK.The primary aim is to determine migration, comparing intraoperative surgeon report examination routine plain radiograph 2 weeks after surgery. EM defined as detection movement two or more electrodes out cochlea from time Multivariate analysis...
Objective Pure tone audiometry (PTA) is the gold standard for hearing assessment. However, it requires access to specialized equipment. Smartphone applications (apps) have been developed perform automated threshold and could allow patients self‐administered screening or monitoring. This study aimed assess validity feasibility of using apps self‐assess thresholds at home, with comparison PTA. Methods A multi‐center, prospective randomized was conducted amongst undergoing PTA in clinics....