A5006859415- Smoking Behavior and Cessation
- Global Public Health Policies and Epidemiology
- Peptidase Inhibition and Analysis
- Consumer Attitudes and Food Labeling
- Obesity, Physical Activity, Diet
- Biochemical Analysis and Sensing Techniques
- Monoclonal and Polyclonal Antibodies Research
- Cellular transport and secretion
- Carcinogens and Genotoxicity Assessment
- Glycosylation and Glycoproteins Research
- Alcohol Consumption and Health Effects
- Hemoglobin structure and function
- Media Influence and Health
- Animal testing and alternatives
- Hemoglobinopathies and Related Disorders
- Polyamine Metabolism and Applications
- Noise Effects and Management
- Cannabis and Cannabinoid Research
- Viral Infections and Vectors
- Shoulder Injury and Treatment
- Agricultural Economics and Policy
- Consumer Packaging Perceptions and Trends
- Misinformation and Its Impacts
- Dermatology and Skin Diseases
- Virus-based gene therapy research
Johns Hopkins University
2015-2025
Research Triangle Park Foundation
1987-2023
Environmental Protection Agency
1987-2023
Berry & Associates (United States)
2022
NHS Greater Glasgow and Clyde
2016-2022
Stanford Health Care
2021
Cleveland Clinic
2020
University of Maryland, Baltimore
2020
University of Maryland Medical Center
2020
Momenta Pharmaceuticals (United States)
2015
Analysis of soluble Ehrlich ascites proteins by the Sanger procedure revealed methionine, alanine, valine, and glycine as major NH2-terminal amino acids. The average monomer weights these calculated from yields acids was 144,000. In contrast, weight data obtained after electrophoresis in polyacrylamide gels containing sodium dodecyl sulfate 32,500. explanation for disparity estimates procedures appears to be that extensive blocking alpha-NH2 groups acetate occurs proteins, i.e. present...
Abstract Erythropoiesis in the chick involves synthesis of multiple hemoglobins. The hemoglobins found late embryo and adult chicken are called A D, early E, P, M. We have determined peptide chain composition embryonic E P. During chromatographic separation P from red cell lysate a 5-day embryo, previously unsuspected hemoglobin (M) was discovered which appears to be present also 7-day embryos. Using rabbit antisera against it that very similar antigenically M D were related, although not as...
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
The US Environmental Protection Agency Toxicity Forecaster (ToxCast) program makes
A simplified DNA hybridization method was developed to detect acyclovir-resistant isolates of herpes simplex virus. Herpes virus-infected cell cultures in microtiter plates were treated with concentrations acyclovir ranging from 8 0.015 micrograms/ml. At 48 h postinfection, infected cells lysed by a one-step procedure and lysates absorbed membranes. Without further treatment, membranes hybridized using virus-specific radioiodinated probe. The then washed counted gamma counter. elapsed time...
Background: Tobacco remains the world's leading preventable cause of death, with majority tobacco-caused deaths occurring in low- and middle-income countries. The first global health treaty, Framework Convention on Control (FCTC), outlines a set policy initiatives that have been demonstrated as effective reducing tobacco use. Article 11 FCTC focuses using package to communicate harms; it also seeks restrict delivery misleading information about product pack. Objective: objective this study...
Menthol cigarettes are associated with increased initiation and progression to regular smoking decreased likelihood of cessation.1–8 smokers more likely be women adolescents in several countries.9 The Conference the Parties Framework Convention on Tobacco Control recommend that regulate ingredients make palatable, including flavouring substances like menthol.10 Canadian province Nova Scotia became first jurisdiction implement a ban menthol tobacco products May 2015, Alberta followed...
The respiratory infectivity of a strain Rift Valley fever virus isolated in Egypt (strain ZH-501) was compared with that one isolate from Uganda (Entebbe strain) and two isolates South Africa (strains SA-51 SA-75). Studies were performed ICR mice which infected by exposure to infectious aerosols composed particles mass median diameter 0.96 micrometer. lethal doses for ZH-501, Entebbe, SA-51, SA-75 2.2, 1.9, 2.6, 1.9 log10 plaque-forming units, respectively. Although these values are...
Abstract The H-2K glycoproteins from two mouse mutants B6.C-H-2ba (Hzl) and B6-H-2bd (M505) were isolated, by tryptic peptide mapping techniques, compared with each other the glycoprotein parent strain C57BL/6 (H-2b). elution profile of acid-soluble peptides H-2Kba showed that at least to three arginine-labeled one lysine-labeled different H-2Kb product parent. These distinct soluble which constitute difference was found between products H-2bd H-2b strains. comparative maps thus demonstrate...
The present study aimed to examine the public reaction death of Steve Jobs, focusing on general and cancer-specific information seeking interpersonal communication. Shortly after Jobs's death, employees from a large university in Southeastern United States (N = 1,398) completed web-based survey. Every employee had heard about 97% correctly identified pancreatic cancer as cause his death. General (50%) cancer–specific (7%) seeking, well (74%) (17%) communication, took place response In...
Background The Philippines has a high smoking prevalence and one of the largest tobacco menthol market shares in world. Flavour capsule cigarettes were introduced to 2013, most which are flavoured, their share is increasing. We explored perceptions flavoured cigarette packaging among young adult Filipinos. Methods conducted eight focus groups with 63 adults ages 18–24 years Manila 2019, stratified by gender status. thematic analysis transcripts. Results Most participants assessed relative...
Cauda equina syndrome (CES) has significant medical, social, and legal consequences. Understanding the number of people presenting with CES their demographic features is essential for planning healthcare services to ensure timely appropriate management. We aimed establish incidence in a single country stratify by age, gender, socioeconomic status. As no consensus clinical definition exists, we compared using different diagnostic criteria.All patients radiological compression cauda due...
In the human disease a-1-proteinase inhibitor deficiency, some variants of are not secreted.These secretory contain frameshift mutations leading to products with normal amino acid sequences points followed by short, aberrant C-terminal and then premature termination (Nukiwa, T., Takahashi,
Abstract The H-2K and H-2D glycoproteins from the mutant mouse strain B10.D2.M504 (H-2Kd,Dda) were compared with molecules parent nonmutant B10.D2 (H-2Kd,Dd). Whereas in every respect K of cells identical, Dda molecule showed notable differences Dd parent. First, smaller amounts (ca. 25%) glycoprotein appeared to be present M504 cell extracts as amount extracts. Second, a proportion an abnormal interaction lectin lentil beans (LcH), suggesting altered carbohydrate chain on some molecules....
Human alpha-1-proteinase inhibitor (A1PI) deficiency, associated with the Z-variant A1PI (A1PI/Z) gene, results from defective secretion of liver. The A1PI/Z gene exhibits two point mutations which specify amino acid substitutions, Val-213 to Ala and Glu-342 Lys. functional importance these substitutions in deficiency was investigated by studying synthesized COS cells transfected genes altered site-directed mutagenesis. This model system correctly duplicates defect seen individuals...
On October 5, 2011, the Chief Executive Officer of Apple®, Inc., Steve Jobs, died from pancreatic cancer. Media outlets covered event with fervor, and public responded in kind. The purpose this study was to examine reaction Jobs's death cancer relation general health-specific information-seeking, as well interpersonal communication. Using a survey conducted within weeks (N = 401), high awareness found, were significant amounts information-seeking communication regard his death. Emotional...
Abstract Background/Aims To estimate and compare price differences between legal illicit cigarettes in 14 low‐ middle‐income countries (LMIC). Design A cross‐sectional census of all packs available on the market was purchased. Setting Cigarette were purchased formal retail settings three major cities each LMIC: Bangladesh, Brazil, China, Egypt, India, Indonesia, Mexico, Pakistan, Philippines, Russia, Thailand, Turkey, Ukraine Vietnam. Participants total 3240 (range = 58 Egypt to 505 Russia)....
Background Flavoured cigarettes are popular in Mexico. We examined how cigarette packaging design features used to communicate flavour influence perceptions of appeal, harm, perceived interest and pack preference among Mexico City residents. Methods conducted an experimental survey. Participants aged 13–34 years were randomly assigned one three conditions, viewed packs with systematically manipulated (colour, capsule image name) answered questions on preference. Data analysed using mixed...