A5083145957- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Bladder and Urothelial Cancer Treatments
- Respiratory and Cough-Related Research
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Cystic Fibrosis Research Advances
- Bacterial Infections and Vaccines
- Urinary Tract Infections Management
- Prostate Cancer Diagnosis and Treatment
- Regional resilience and development
- Urinary and Genital Oncology Studies
- Regional Economics and Spatial Analysis
- Urological Disorders and Treatments
- Respiratory viral infections research
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- COVID-19 and healthcare impacts
- Pediatric health and respiratory diseases
- Streptococcal Infections and Treatments
- Economic and Technological Innovation
- Asthma and respiratory diseases
- Urinary Bladder and Prostate Research
Cambridge University Hospitals NHS Foundation Trust
2022-2025
Shadyside Hospital
2020-2023
Evidence (Italy)
2023
Michigan Department of Education
2023
American Urological Association
2023
Stanford University
2020-2022
Motu Economic and Public Policy Research
2019-2021
University of Birmingham
2020
Loughborough University
2020
Birmingham Children's Hospital
2020
Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack standardised clinical definitions outcome measures. This prospective multi-centre observational cohort study adults with UK. We assessed presentation, investigation, management, all Core Outcome Set domains up one year post-operatively using clinician participant reporting....
Study Type – Therapy (case control) Level of Evidence 3b What's known on the subject? and What does study add? The risks delayed radical prostatectomy for men who progress active surveillance are largely unknown. Two series have reported that after has similar results to immediate therapy. Our data add this growing body evidence appropriately selected with prostate cancer can undergo without added risk missing an opportunity cure as majority tumours remain organ confined. OBJECTIVE • To...
We derive a measure of the relatedness between economic activities based on weighted correlations local employment shares. Our approach recognizes variation in extent specialization and adjusts for differences data quality cities. use our to estimate activity city complexity, examine contribution complexity urban growth New Zealand. Relatedness are complementary promoting Zealand's largest cities, but do not contribute its smaller
Pyogenic spondylodiscitis management often remains conservative without surgical intervention, yet the risk of spinal deformity under such therapy is unclear. This study explores progression in conservatively treated patients and identifies predictive factors for advancement. Retrospective cohort design with radiological data analysis from 59 pyogenic spondylodiscitis. Deformities were categorized into four types reflecting severity: Type 1 (progressive vertebral body edema/endplate...
Fifteen patients admitted to hospital with acute purulent exacerbations of chronic bronchitis were treated enoxacin by mouth (three 200 mg capsules twice daily) for ten days. Sputum was cultured before, during and after the treatment course. Serum sputum concentrations measured microbiologically at intervals on first day. Blood assayed 1, 1 1/2, 2, 2 3, 5 7 h dose unhomogenized tested in samples collected 0-2, 2-4, 4-6 6-8 this dose. The highest serum usually noted or 1/2 medication ranged...
During the initial clinical evaluation of a new aminopenicillin, bacampicillin, 21 patients were treated for acute exacerbations chronic bronchitis. The study was "single-blind" and comprised three dose-levels, which permitted systematic dose-response relationships. Both ampicillin levels in serum sputum outcome dose-dependent. Sputum purulence found to be significant factor predicting outcome. With 400 800 mg bacampicillin t.i.d. mean inhibitory Haemophilus influenzae maintained at least 6...
Twenty-eight strains of Branhamella catarrhalis, isolated from patients with acute exacerbations chronic bronchitis, were tested both for beta-lactamase production and sensitivity to a wide range antimicrobial agents. A microtitre broth dilution technique was used the latter MIC50, MIC90, geometric mean MIC values all calculated. Eleven found produce beta-lactamases. Isoelectric focusing in polyacrylamide gels showed four different band patterns, which most common identical that Ravasio type...
Journal Article Azithromyrin (CP-62,993) in acute exacerbations of chronic bronchitis: an open clinical, microbiological and pharmacokinetic study Get access B. I. Davies, Davies aDepartment MicrobiologyThe Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar F. P. V. Maesen, Maesen bDepartment Respiratory Diseases, De Wever Ziekenhuis, HeerlenThe R. Gubbelmans Antimicrobial Chemotherapy, Volume 23, Issue 5, May 1989, Pages 743–751,...
Most retroperitoneal tumors such as renal cell carcinoma have been associated with tumor thrombus extending into the vein, inferior vena cava (IVC), and heart. The metastatic potential of testicular is well known. We report here first instance a cardiac murmur prompting diagnosis neoplasia in an 18-year-old patient. Chemotherapy was delayed after successful surgical resection ventricular mass, patient recovered uneventfully. This case underscores need to pursue abnormal exams newly diagnosed...
Forty-three patients admitted to hospital with acute purulent exacerbations of chronic bronchitis were treated 400 mg pefloxacin twice daily for ten days. The first 20 given the dose drug as a 60 min intravenous infusion. Serum and sputum concentrations measured microbiologically at intervals on treatment day was cultured before, during, after course pefloxacin. Two died from unrelated causes during follow-up one refused continue treatment. All strains Haemophilus influenzae Branhamella...
Abstract The objective of this randomized, double-blind study was to compare the clinical efficacy levofloxacin at two different dosages with that cefuroxime axetil in patients acute purulent exacerbations chronic bronchitis and, particular, assess impact susceptibility on findings. In total, 124 evaluable were treated for 7 days oral 250 mg or 500 od, bd. Sputum cultures monitored pre-treatment, and 1 after end treatment. Streptococcus pneumoniae isolates tested by agar dilution Columbia...
With the API 20 E Enterobacteriaceae system of biochemical testing, a biotype, coded numerically, was determined for each 574 strains Escherichia coli isolated from patients with urinary tract infection. The serotypes were also determined. Fifty-five different biotypes identified, two accounting together 42% examined and seven others between 8.4 1.9%. There little correlation biotype serotype. Fifty pairs before treatment. In 43 serotype both pair same. six but not serotypes, differed,...
Twenty patients, all admitted to hospital with acute purulent exacerbations of chronic bronchitis associated Haemophilus influenzae, Streptococcus pneumoniae or β-lactamase producing Branhamella catarrhalis were treated twice daily for ten days amoxycillin/clavulanate. Ten patients first given 1000 mg amoxycillin 200 potassium clavulanate intravenously bd three days, before crossing the standard oral regimen + 250 bd. Clinical results on day 10 excellent in 16/20 but 14 developed recurrences...