A5006826514- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Brain Metastases and Treatment
- Alzheimer's disease research and treatments
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Cerebrovascular and genetic disorders
- Neuroendocrine Tumor Research Advances
- MicroRNA in disease regulation
- Protease and Inhibitor Mechanisms
- Inflammatory Bowel Disease
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Prion Diseases and Protein Misfolding
- Chromatin Remodeling and Cancer
- DNA Repair Mechanisms
- Neurological diseases and metabolism
- Radiation Therapy and Dosimetry
- Acute Ischemic Stroke Management
- Anesthesia and Neurotoxicity Research
University of Szeged
2015-2025
King's College Hospital NHS Foundation Trust
2020-2025
King's College Hospital
2020-2025
King's College London
2023
University of Exeter
2023
Inherited prion diseases (IPD) secondary to mutations of the protein gene, PRNP, exhibit diverse clinical phenotypes, capable mimicking numerous primary neurodegenerative conditions. We describe phenotype and neuropathological findings in a family from County Limerick Ireland presenting with Alzheimer's disease-like cognitive decline motor symptoms caused by novel missense mutation PRNP. This occurs PRNP central lysine cluster (CLC; codon 101-110), resulting substitution threonine isoleucine...
Stromal cells, including cancer-associated myofibroblasts (CAMs), are recognised to be determinants of cancer progression, but the mechanisms remain uncertain. The chemokine-like protein, chemerin, is upregulated in oesophageal squamous (OSC) CAMs compared with adjacent tissue (ATMs). In this study, we hypothesised that chemerin stimulates OSC cell invasion. Expression receptor, ChemR23, was examined by immunohistochemistry. invasion cells studied using Boyden chambers and organotypic...
Breast cancer brain metastases (BCBMs) have been underinvestigated despite their high incidence and poor outcome. MicroRNAs (miRNAs), particularly circulating miRNAs, regulate multiple cellular functions, deregulation has reported in different types of metastasis. However, signature plasma along metastasis development relevant targets remain undetermined. Here, we used a mouse model BCBM next‐generation sequencing (NGS) to establish the alterations miRNAs during formation development. We...
// J. Dinesh Kumar 1 , Iman Aolymat Laszlo Tiszlavicz 2 Zita Reisz Hanan M. Garalla Rob Beynon 3 Deborah Simpson Graham Dockray and Andrea Varro Department of Cellular Molecular Physiology, Institute Translational Medicine, University Liverpool, UK Pathology, Szeged, Hungary Centre for Proteome Research, Integrative Biology, Correspondence to: Varro, email: avarro@liverpool.ac.uk Keywords: chemerin; gastric cancer; myofibroblasts; proteomic Received: September 30, 2018 Accepted: November 16,...
Brain metastases are life-threatening complications of triple-negative breast cancer, melanoma, and a few other tumor types. Poor outcome cerebral secondary tumors largely depends on the microenvironment formed by cells neurovascular unit, among which pericytes least characterized. By using in vivo vitro techniques human samples, here we show that play crucial role development metastatic brain directly influencing key steps disease. had prompt chemoattractant effect cancer established direct...
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), K27-altered, hemispheric (DHG), G34-mutant). The WHO classification recognises in exceptional cases, these co-occur. We report one such case a 2-year-old female presenting with neurological symptoms; MRI imaging identified brainstem lesion which was biopsied. Histology showed diffusely infiltrating pleomorphic astrocytes,...
Abstract Background: High-grade gliomas (HGG) occur in any central nervous system (CNS) location and age. HGGs teenagers/young adults (TYA) are understudied. This project aimed to characterise these tumours support accurate patient stratification. Methods: 207 histone/IDH-wildtype from patients aged 13–30 years were collected. DNA methylation profiling (Illumina EPIC BeadArrays, brain tumour classifier (MNPv12.6 R package)) classified cases against reference cohorts. Calibrated scores guided...
MGMT promoter methylation is related to the increased sensitivity of tumour tissue chemotherapy with temozolomide (TMZ) and thus improved patient survival. However, it unclear how extent affects outcomes. In our study, a single-centre retrospective we explore impact in patients glioblastoma who were operated upon 5-ALA. Demographic, clinical histology data, survival rates assessed. A total 69 formed study group (mean age 53.75 ± 15.51 years old). Positive 5-ALA fluorescence was noted 79.41%....
Abstract Aims Cerebral amyloid angiopathy (CAA)‐related inflammation (CAA‐RI) is a potentially reversible manifestation of CAA, histopathologically characterised by transmural and/or perivascular inflammatory infiltrates. We aimed to identify clinical, radiological and laboratory variables capable improving or supporting the diagnosis predicting/influencing prognosis CAA‐RI retrospectively evaluate different therapeutic approaches. Methods present clinical neuroradiological observations in...
Stromal cells influence epithelial function in both health and disease. Myofibroblasts are abundant stromal that the cellular microenvironment by release of extracellular matrix (ECM) proteins, growth factors, proteases, cytokines, chemokines. Cancer-associated myofibroblasts (CAMs) differ from adjacent tissue (ATMs) normal (NTMs), but basis this is incompletely understood. We report now differential expression miRNAs gastric cancer CAMs. MicroRNA arrays identified differences miRNA profile...
Despite its clinical relevance, cerebral amyloid angiopathy (CAA) is underdiagnosed worldwide. This retrospective study aimed to assess the incidence, etiology, predictors, and outcome of intracerebral hemorrhages (ICHs) in this region, with special focus on possible underlying CAA. Database screening acute cares intracranial hemorrhage diagnosis within 01/07/2014-01/07/2018 were conducted analyzing medical records imaging. Spontaneous ICHs classified as deep (basal...
Matrix metalloproteinase (MMP)-7, unlike many MMPs, is typically expressed in epithelial cells. It has been linked to responses infection, injury, and tissue remodeling including the progression of a number cancers. We have now examined how MMP-7 expression changes esophageal adenocarcinoma (EAC), studied mechanisms regulating its functional significance. Immunohistochemistry revealed that was weakly normal squamous epithelium adjacent EAC but abundant cells both preneoplastic lesions...
DOORS (deafness, onychodystrophy, osteodystrophy, intellectual disability (mental retardation), and seizures) syndrome can be caused by mutations in the TBC1D24 ATP6V1B2 genes, both of which are involved endolysosomal function. Because its extreme rarity, to date, no detailed neuropathological assessment has been performed establish clinicopathological relationships and, thereby, understand better neurobiology this disease aged cases. Accordingly, aim current study was highlight...
is a peer-reviewed open access academic journal that aims to guide clinical practice and improve diagnostic therapeutic skills of clinicians.WJGS covers topics concerning micro-invasive surgery; laparoscopy; hepatic, biliary, pancreatic splenic surgical nutrition; portal hypertension, as well associated subjects.The current columns WJGS include editorial, frontier, advances, therapeutics field vision, mini-reviews, review, topic highlight
Abstract BACKGROUND Histone mutations (H3 K27M, H3 G34R/V) define subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), K27-altered, hemispheric (DHG), G34-mutant). The WHO classification recognises exceptional cases where these co-occur. We report one such case a 2-year-old female presenting with neurological symptoms and lethargy. METHODS MRI imaging identified brainstem lesion; stereotactic needle biopsy was undertaken, followed by standard diagnostic...
Background/Objectives: 5-aminulevulinic acid (5-ALA)-guided surgery for high-grade gliomas remains a challenge in neuro-oncological surgery. Inconsistent fluorescence visualisation, subjective quantification and false negatives due to blood, haemostatic agents or optical impediments from the external light source are some of limitations present technology. Methods: The preliminary results this single-centre retrospective study presented first 35 patients operated upon with novel Nico Myriad...
To study the changes of glioblastoma multiforme during chemoradiotherapy (CRT) and to evaluate impact on dosimetry clinical outcomes.Forty-three patients underwent volumetric imaging-based replanning. Prognostic factors gross tumor volume in relation overall survival effect adaptive replanning were statistically analyzed.Patients with total removal, shorter time CRT (<27 days), methylated O-6 methylguanine DNA methyltransferase good performance status (>60%) had better survival. Tumor...
Purpose: The recent rapid increase of hadron therapy applications requires the development high performance, reliable in vivo models for preclinical research on biological effects linear energy transfer (LET) particle radiation.Aim: aim this paper was to test relative effectiveness (RBE) zebrafish embryo system at two neutron facilities.Material and Methods: Series viable embryos 24-hour post-fertilization (hpf) were exposed single fraction, whole-body, photon (reactor fission neutrons (<En...
The prevalence of xeroderma pigmentosum (XP) is quite low in Europe, which may result a delay determining the appropriate diagnosis. Furthermore, some subtypes XP, including XPA, manifest themselves with severe neurological symptoms addition to characteristic dermatological lesions. Accordingly, aim current study highlight predominant aspects as well mild-to-moderate signs Hungarian family 5 affected siblings. Caucasian male proband started develop at 13–14 years age predominantly...