A5032267755- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Intracranial Aneurysms: Treatment and Complications
- Optical Imaging and Spectroscopy Techniques
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Neurosurgical Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Cervical and Thoracic Myelopathy
- Pelvic and Acetabular Injuries
- Photoacoustic and Ultrasonic Imaging
- Hip and Femur Fractures
- Glioma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal and fetal brain pathology
- Intraoperative Neuromonitoring and Anesthetic Effects
- CNS Lymphoma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Plant Toxicity and Pharmacological Properties
Amsterdam UMC Location University of Amsterdam
2005-2024
University of Amsterdam
1993-2024
Amsterdam University Medical Centers
2019-2024
Amsterdam Neuroscience
2005-2024
OLVG
2018-2024
Health & Safety in Sports
2024
University of Groningen
2023
Colorado State University
2023
GGZ Noord-Holland-Noord
2023
Leiden University Medical Center
2023
✓ Although experimental and pathological studies suggest an important role for ischemia in the majority of fatal cases traumatic brain injury, has been a rare finding most clinical cerebral blood flow (CBF) head-injured patients. The hypothesis present study was that occurs first few hours after but CBF measurements have not performed early enough. Early (by 133 Xe intravenous method) arteriovenous oxygen difference (AVDO 2 ) were obtained 186 adult patients with Glasgow Coma Scale score 8...
✓ Intravascular volume expansion has been successfully employed to promote blood flow in ischemic brain regions. This effect attributed both decreased viscosity and increased cardiac output resulting from expansion. The physiological mechanism by which changes would affect cerebral (CBF), independent of pressure variations, is unclear, but impaired autoregulation believed play a role. In order evaluate the relationship between CBF when either intact or defective, 135 simultaneous...
Objective This study describes the 5 years’ results of Sciatica trial focused on pain, disability, (un)satisfactory recovery and predictors for unsatisfactory recovery. Design A randomised controlled trial. Setting Nine Dutch hospitals. Participants Five follow-up data from 231 283 patients (82%) were collected. Intervention Early surgery or an intended 6 months conservative treatment. Main outcome measures Scores Roland disability questionnaire, visual analogue scale (VAS) leg back pain a...
Patients with large annular defects after lumbar discectomy for disc herniation are at high risk of symptomatic recurrence and reoperation.The present study aimed to determine whether a bone-anchored closure device, in addition microdiscectomy, resulted lower reherniation reoperation rates plus increased overall success compared microdiscectomy alone.This is multicenter, randomized superiority study.Patients symptoms least 6 weeks defect (6-10 mm width) were included the study.The co-primary...
The effects of aneurysmal subarachnoid hemorrhage on morphology and function the cerebral microcirculation are poorly defined, partly due to lack suitable techniques visualize microvessels in vivo. We used orthogonal polarization spectral (OPS) imaging brain cortex during aneurysm surgery directly observe small cortical blood vessels quantify their responses hypocapnia.In 16 patients undergoing surgery, diameter changes (15 180 microm) were observed using OPS imaging. Ten operated early...
Previous studies using the xenon-133 cerebral blood flow (CBF) method have documented impairment of CO2 vasoresponsivity after a severe head injury, but only global values can be obtained reliably with this technique. We studied stable xenon-enhanced computed tomographic CBF method, which provided information about well-defined cortical regions and deep brain structures not available method. In 17 patients admission Glasgow Coma Scale scores 8 or less, hemispheric ranged from 1.3 to 8.5% per...
Local brain tissue oxygen (ptiO2) monitoring is frequently applied in patients at risk for cerebral ischemia. To identify ischemic thresholds, the normal range of local pressure values needs to be established. Ideally, such are determined healthy and awake subjects, so as eliminate possible influences anesthetics on physiology or ptiO2. Thus far, however, measurements have not been conducted, fill this void, we ptiO2 white matter undergoing functional stereotactic surgery. In 25 otherwise...
Patients with recurrent sciatica due to repeated reherniation of the intervertebral disc carry a poor prognosis for recovery and create large burden on society. There is no consensus about best treatment this patient group. The goal study was evaluate 12-month results placement stand-alone Trabecular Metal cages in these patients.The authors performed retrospective analysis 26 patients herniations treated posterior lumbar interbody fusion (PLIF) cages. At 1 year were evaluated using Roland...
Abstract Background The optimal treatment for odontoid fractures in older people remains debated. Odontoid are increasingly relevant to clinical practice due ageing of the population. Methods An international prospective comparative study was conducted fifteen European centres, involving patients aged ≥55 years with type II/III fractures. surgeon and patient jointly decided on applied treatment. Surgical conservative treatments were compared. Primary outcomes Neck Disability Index (NDI)...
Abstract Previous studies using the xenon-133 cerebral blood flow (CBF) method have documented impairment of CO2vasoresponsivity after a severe head injury, but only global values can be obtained reliably with this technique. We studied stable xenon-enhanced computed tomographic CBF method, which provided information about well-defined cortical regions and deep brain structures not available method. In 17 patients admission Glasgow Coma Scale scores 8 or less, hemispheric ranged from 1.3 to...
<p class="abstract"><strong>Background:</strong> Same-level reherniation and progressive degeneration with disc height loss are main causes of poor outcome after discectomy may necessitate reoperation. A novel prosthesis for anular closure was developed to address these causes.</p><p class="abstract"><strong>Methods:</strong> The design a multicenter, prospective, randomized, post-market superiority trial comparing limited lumbar augmented this...
Objective Discectomy as a treatment for herniated lumbar discs results in outcomes after surgery that are not uniformly positive. Surgeons face the dilemma between limited nucleus removal which is associated with higher risk of recurrence, or more aggressive may lead to disc height loss and persistent back-pain. annulus closure devices allow benefits without increased recurrence. This an interim report ongoing 24-month post-marketing study Barricaid® device, consisting flexible polymer mesh...
Despite observations that pial arterioles constrict with decreased blood viscosity or hemodilution, several investigators have found an inverse relationship between cerebral flow (CBF) and hematocrit (Hct) under physiological conditions. To investigate whether this is due to a dilation of the more proximal large arteries, in vivo responses CBF basilar artery hemodilution hemoconcentration were studied 21 anesthetized normal cats, using closed clival window model. An correlation Hct was...
<b>Objective</b> To assess the potential benefits of disk reherniation reduction and height maintenance in limited diskectomy combined with implantation anular closure device. <b>Summary Background Data</b> Postoperative loss is apparent most patients undergoing lumbar for herniated nucleus pulposus. Less favorable patient outcomes are associated significant that can occur after aggressive tissue removal. More conservative removals, however, often burdened by increased risk recurrent...
Patients with large annular defects following lumbar microdiscectomy for disc herniation are at increased risk symptomatic recurrence and reoperation.To determine whether a bone-anchored closure device in addition to resulted lower reherniation reoperation rates vs alone.This secondary analysis of multicenter randomized clinical trial reports 5-year follow-up enrolled patients between December 2010 October 2014 21 sites. this study had defect (6-10 mm width) treatment herniation. Statistical...