A5027129768- Glioma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Extracellular vesicles in disease
- Medical Imaging and Analysis
- Anatomy and Medical Technology
- Cerebral Palsy and Movement Disorders
- Spinal Fractures and Fixation Techniques
- Neurological disorders and treatments
- Nanoplatforms for cancer theranostics
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Surgical Simulation and Training
- Memory and Neural Mechanisms
- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- History of Medical Practice
- Muscle Physiology and Disorders
- Viral Infections and Vectors
- Ion channel regulation and function
- Neurology and Historical Studies
- Telemedicine and Telehealth Implementation
- Diet and metabolism studies
University Hospitals Sussex NHS Foundation Trust
2024
Royal College of Surgeons in Ireland
2022-2024
Royal Sussex County Hospital
2024
Botsford Hospital
2022
Beaumont Hospital, Dearborn
2022
Evangelismos Hospital
2021-2022
Beaumont Hospital
2022
Stepping Hill Hospital
2021-2022
Stockport NHS Foundation Trust
2022
Leeds General Infirmary
2021-2022
Glioblastoma (GBM) is the most common and fatal primary brain tumour in adults. Considering that resistance to current therapies leads limited response patients, new therapeutic options are urgently needed. In recent years, differentiation therapy has been proposed as an alternative for GBM treatment, with aim of bringing cancer cells into a post-mitotic/differentiated state, ultimately limiting growth. As integral component development regulation processes, kinases potential targets...
Huntington's disease (HD) is one of a group neurodegenerative diseases caused by an expanded trinucleotide (CAG) repeat coding for extended polyglutamine tract. The inherited in autosomal dominant manner, with onset motor, cognitive, and psychiatric symptoms typically occurring midlife, followed unremitting progression eventual death. We report here that motor presymptomatic R6/1 HD mice show severe impairment somatosensory-discrimination learning ability behavioral task depends heavily on...
Abstract Background Extracellular vesicles (EVs) are amongst the most promising candidates for developing blood-based biomarkers. However, patient sample availability is a key barrier to translational research whilst biobanks store samples of 1.5mL volume or less. To date, there no consensus on suitable method EV separation and current techniques frequently require large volumes biofluids, complicated technology, technical expertise, significant operating costs, which prevents their...
Background: Huntington's disease (HD) is caused by a tandem repeat expansion and involves progressive cognitive decline, psychiatric abnormalities motor deficits. Disease onset progression in HD mice can be substantially delayed housing
Glioblastoma (GB) is an aggressive type of tumour for which therapeutic options and biomarkers are limited. GB diagnosis mostly relies on symptomatic presentation the and, in turn, brain imaging invasive biopsy that can delay its diagnosis. Description easily accessible effective present biofluids would thus prove invaluable Extracellular vesicles (EVs) derived from both stromal cells essential to intercellular crosstalk bulk, circulating EVs have been described as a potential reservoir...
Multiple myeloma involving the thyroid cartilage is a very uncommon disease entity. Only 10 cases have been reported in international literature to date and as such it constitutes rare challenging diagnosis make. We report case of 63-year-old man with background malignant melanoma multiple both which were remission at time presentation. The patient presented hoarseness large neck mass that turned out be an extramedullary deposit his previously treated indicating relapse. differential...
We report a case of an interventricular ependymoma which was surgically removed but also required bilateral transection the fornices resulting in memory impairment gradually improved. Functional MR images using paradigm showed that recovery correlated with cortical plasticity involving activation orbitofrontal cortex and middle temporal gyrus.
Abstract BACKGROUND Glioblastoma (GBM) is a disease of older adults with peak incidence at 65-74 years. Treatment this group challenging and varies significantly. We sought to define treatment patterns outcomes for patients aged >65 GBM diagnosed by WHO CNS 5. MATERIAL AND METHODS identified pathologically confirmed GBMs in 2021 multicentre retrospective study. Patients were treated as per centre’s routine practice. Demographic, tumour characteristics recorded survival calculated from...
We report the case of a 14-month-old infant presenting with unresponsiveness and seizure following thoracic surgery. Imaging showed full territory left middle cerebral artery infarct signs raised intracranial pressure (ICP) that required emergency decompressive craniectomy (DC). The child made good functional recovery. discuss case.
Abstract OBJECTIVE: To provide an educational, comprehensive, systematic and stepwise manual for the dissection illustration of major limbic structures since there is a gap in pertinent literature. Further, we aim to offer thorough yet simplified roadmap laboratory intraoperative dissections. METHODS: Twenty (20) normal adult, formalin-fixed cerebral hemispheres were studied through fiber technique under microscope. Stepwise tandem medial lateral dissections performed all specimens aiming...
Abstract High grade gliomas are the most common primary brain tumors in adults, but also occur childhood, with a poor prognosis all age groups . Lemur tyrosine kinase 3 (LMTK3) is transmembrane that seems to play pivotal role oncogenesis breast cancer. It regulates estrogen receptor alpha and evolutionarily selected for humans compared non-human primates. LMTK3 expression levels were strongly associated survival therapy response.This study assesses of pediatric high at both protein mRNA...
We report a case of accidental intracranial insertion foreign body through the nose resulting in dural tear and subsequent CSF leak. also describe surgical approach to remove it new method seal defect.
Abstract Introduction Transforaminal Lumbar Interbody Fusion (TLIF) is a technique used for the management of various pathologies such as degenerative disc disease, recurrent herniations and spondylolisthesis, to mention most common indications. There an ongoing debate regarding use open versus minimally invasive techniques TLIF. Each has its own advantages disadvantages. In present study, we aim our experience vs MIS TLIF at Stepping Hill Hospital in Manchester. Method A retrospective...
Abstract AIMS Description of effective biomarkers present in biofluids could prove invaluable GBM diagnosis. Extracellular vesicles (EVs) are essential to intercellular crosstalk the tumour bulk and circulating EVs have been described as a potential reservoir biomarkers. Therefore, EV-based liquid biopsies suggested promising tool for METHOD Ethical approval was obtained prospective study healthy donors consenting patients at University Hospitals Sussex (Brighton). To identify specific...