A5042034561- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Dendrimers and Hyperbranched Polymers
- Antimicrobial agents and applications
- Gene expression and cancer classification
- Antimicrobial Peptides and Activities
- Statistical Methods and Inference
- Child and Adolescent Health
- Respiratory Support and Mechanisms
- Advanced Radiotherapy Techniques
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Asthma and respiratory diseases
- Surfactants and Colloidal Systems
- Anomaly Detection Techniques and Applications
- Pharmaceutical Economics and Policy
- Surface Modification and Superhydrophobicity
- Biosimilars and Bioanalytical Methods
- Diversity and Career in Medicine
- Respiratory and Cough-Related Research
- Biomedical Ethics and Regulation
- Ethics in medical practice
- Head and Neck Cancer Studies
University of Toronto
2024
Queen's University
2023-2024
Wolters Kluwer Health
2024
NHS Grampian
2024
Florida Atlantic University
2023-2024
Barbados Community College
2023
Baptist Hospital of Miami
2021-2022
Baptist Health South Florida
2021-2022
Nemours Children's Health System
2017-2019
Levine Cancer Institute
2019
Abstract Introduction Dysphagia is common among survivors of critical illness who required mechanical ventilation during treatment. The risk factors associated with the development postextubation dysphagia, and effects dysphagia on patient outcomes, have been relatively unexplored. Methods We conducted a retrospective, observational cohort study from 2008 to 2010 all patients over 17 years age admitted university hospital ICU subsequently received bedside swallow evaluation (BSE) by speech...
<h3>Background</h3> There is notable heterogeneity in the clinical presentation of patients with COPD. To characterise this heterogeneity, we sought to identify subgroups smokers by applying cluster analysis data from COPDGene study. <h3>Methods</h3> We applied a clustering method, k-means, 10 192 After splitting sample into training and validation set, evaluated three sets input features across range <i>k</i> (user-specified number clusters). Stable solutions were tested for association...
Abstract Introduction Critically ill patients can develop acute respiratory failure requiring endotracheal intubation. Swallowing dysfunction after liberation from mechanical ventilation, also known as post-extubation dysphagia, is common and deleterious among without neurologic disease. However, the risk factors associated with development of dysphagia its effect on hospital lengthofstay in critically disorders remains relatively unexplored. Methods We conducted a retrospective,...
Health status and outcomes are frequently measured on an ordinal scale. For high‐throughput genomic datasets, the common approach to analyzing response data has been break problem into one or more dichotomous analyses. This does not make use of all available therefore leads loss power increases number type I errors. Herein we describe innovative frequentist that combines two statistical techniques, L 1 penalization continuation ratio models, for modeling using gene expression microarray...
Background COPD patients have a great burden of comorbidity. However, it is not well established whether this due to shared risk factors such as smoking, if the comorbidities impact patients' exercise capacity and quality life, or there are racial disparities in their on C
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder associated with systemic manifestations that contribute to its morbidity and mortality. Recent work suggests biomarker signatures in the blood may be useful evaluating COPD phenotypes provide insight into pathophysiology of manifestations. Adiponectin, primarily produced by fat cells, has been implicated emphysema.
ABSTRACT Objective: Proton pump inhibitors (PPIs) are an effective treatment for eosinophilic esophagitis (EoE); however, only 30% to 60% of patients respond. Common genetic variants in CYP2C19 and STAT6 associate with PPI plasma concentration magnitude inflammatory response, respectively. Our objective was determine if variation the genes influence differentiation between responsive esophageal eosinophilia versus nonresponsive EoE (PPI‐REE, PPI‐nonresponsive EoE). Methods: Genomic DNA...
The rapid growth of the Internet Things (IoT) has revolutionized industries, enabling unprecedented connectivity and functionality. However, this expansion also increases vulnerabilities, exposing IoT networks to increasingly sophisticated cyberattacks. Intrusion Detection Systems (IDS) are crucial for mitigating these threats, recent advancements in Machine Learning (ML) offer promising avenues improvement. This research explores a hybrid approach, combining several standalone ML models...
Objective: Critically ill patients frequently display impaired decision-making capacity due to their underlying illness and the use of sedating medications. Healthcare providers often rely on surrogates make decisions for medical care participation in clinical research. However, accuracy surrogate a variety critical research studies is poorly understood. Design: Cross-sectional observational study. Setting: Academic center. Patients: Medical intensive unit designated surrogates....
Background Rehospitalization is an important and costly outcome that occurs commonly in several diseases encountered the medical intensive care unit (ICU). Although alcohol use disorders are present 40% of ICU survivors withdrawal most common alcohol-related reason for admission to ICU, rates predictors rehospitalization have not been previously reported this population. Methods We conducted a retrospective cohort study with primary or secondary discharge diagnosis using 2 administrative...
Objectives: The effects of excess alcohol consumption (alcohol misuse) on outcomes in patients with acute lung injury have been inconsistent, and there are no studies examining this association the era low tidal volume ventilation a fluid conservative strategy. We sought to determine whether validated scores Alcohol Use Disorders Identification Test that correspond past-year abstinence (zone 1), low-risk drinking 2), mild moderate misuse 3), severe 4) associated poor injury. Design:...
ObjectivesTo measure the antimicrobial activities of three series homologous, dendritic tricarboxylato (three-headed) amphiphiles against a battery bacteria and fungi.
Abstract Esophageal pH monitoring remains a primary diagnostic tool for detecting gastroesophageal reflux disease (GERD). GERD that is refractory to proton pump inhibitor (PPI) medications may be related CYP2C19 variants. Current PPI dosing practices in children do not take into account allelic variants, which lead underdosing and subsequently misperception of therapy failure. We hypothesized probe acid exposure outcomes associate with * 17 alleles among clinical concern GERD. identified...
The objective of this study was to evaluate the impact time interval between planning imaging and stereotactic radiosurgery (SRS) delivery on tumor volumes spatial anatomic displacements brain metastases (BM).Consecutive patients diagnosed with BM treated SRS over a 3-year period were evaluated. Only who underwent an institutionally standardized diagnostic MRI (MRI-1) treatment (MRI-2) included. histology, inter-scan interval, lesion location, volume, diameter evaluated final diameter,...
Newkome-type, 1→3 C-branched dendrons make an excellent headgroup for amphiphiles with ultralong, saturated, linear alkyl chains. Synthesis of a homologous series five such from 14 to 22 carbonsRNHCONHC(CH2CH2CO2H)3, R = n-CnH2n+1, n 14, 16, 18, 20, 22proceeds readily. These are soluble in aqueous solutions triethanolamine. Surface-tension measurements on this reveal unusually gradual decrease log critical micelle concentration (CMC) as the chain length increases. In fact, tetradecyl...
Antimicrobial coatings deposited onto ultra high molecular weight polyethylene (UHMWPE) films were investigated using an atmospheric pressure - plasma enhanced chemical vapor deposition (AP-PECVD) process. Varying concentrations of a guanidine-based liquid precursor, 1,1,3,3-tetramethylguanidine, used, and different conditions studied. Attenuated total reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy X-ray Photoelectron Spectroscopy (XPS) used to study the structure elemental...
The purposes of this study were to evaluate the effect smoking status on quantitative computed tomography CT measures low-attenuation areas (LAAs) inspiratory and expiratory provide a method adjusting for effect.A total 6762 current former smokers underwent spirometry volumetric CT. Quantitative analysis was completed using open-source 3D Slicer software. LAAs defined as lung voxels with attenuation values ≤-950 Hounsfield units (HU) ≤-856 HU expressed percentage volume (%LAAI-950...
The unique acute effects of the large fractional doses that characterize stereotactic radiosurgery (SRS) or radiotherapy (SRT), specifically in terms antitumor immune cellular processes, vascular damage, tumor necrosis, and apoptosis on brain metastasis have yet to be empirically demonstrated. objective this study is provide first in-human evaluation biological SRS/SRT resected metastasis. Tumor samples from patients who underwent dose-escalated preoperative SRT followed by resection with...