A5043328736- Glioma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Brain Metastases and Treatment
- Medical Imaging and Pathology Studies
- Innovations in Medical Education
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer Genomics and Diagnostics
- Medical Education and Admissions
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Frailty in Older Adults
- Diversity and Career in Medicine
- Cancer Immunotherapy and Biomarkers
- Healthcare cost, quality, practices
- Colorectal Cancer Treatments and Studies
- Economic and Financial Impacts of Cancer
- Body Contouring and Surgery
Royal Devon and Exeter Hospital
2024
University Hospitals Plymouth NHS Trust
2019-2024
Torbay Hospital
2023
Derriford Hospital
2022
University of Oxford
2020
Royal London Hospital
2015
The transition from medical student to junior doctor is challenging, therefore adequate preparation during school crucial for a smooth transition. Tomorrow's Doctors expects students undertake assistantship, separate the local shadowing period prior commencing employment. Sheffield Medical School initiated 6-week assistantship within Yorkshire and Humber deanery. This mixed-methodology study explores this experience perspective of final-year students.Final-year responded questionnaire about...
Abstract Introduction Clinical trials show improved progression‐free survival (PFS) and overall (OS) in first‐line metastatic renal cell carcinoma (mRCC) patients with immunotherapy containing systemic anti‐cancer therapies (SACT). However, the favourable international cancer database consortium (IMDC) group there is no trial evidence for OS benefit despite clear PFS improvement when comparing anti‐VEGF tyrosine kinase inhibitor (TKI) monotherapy (immunotherapy TKI) IO/TKI combinations....
358 Background: The treatment landscape of metastatic renal cell carcinoma (mRCC) has evolved over the last few years with several systemic anti-cancer therapies (SACT) licensed across different lines treatment. A previous real world study in UK had demonstrated a significant attrition rate between each line therapy suggesting less than half patients who received first SACT then second and fifth reach third line. Methods: We conducted retrospective analysis all treated January 2018 end June...
Abstract BACKGROUND Glioblastoma (GBM) is a relatively rare but aggressive tumour with poor outcomes. Most real-world data sets rely on extended time periods to include sufficient patients for analysis. However, diagnostic classifications and treatment patterns change over adding uncertainty regarding current patient MATERIAL AND METHODS We performed an international multicentre retrospective study identify pathologically confirmed GBMs diagnosed in 2021. describe outcomes this up-to-date...
Abstract BACKGROUND Glioblastoma (GBM) is a disease of older adults with peak incidence at 65-74 years. Treatment this group challenging and varies significantly. We sought to define treatment patterns outcomes for patients aged >65 GBM diagnosed by WHO CNS 5. MATERIAL AND METHODS identified pathologically confirmed GBMs in 2021 multicentre retrospective study. Patients were treated as per centre’s routine practice. Demographic, tumour characteristics recorded survival calculated from...
Abstract BACKGROUND Molecular glioblastoma (mGBM), without classical histological features, was defined in the 2021 WHO classification based on select criteria (EGFR amplification, TERT promoter mutation (pTERT), chromosome 7+/10-). Subsequent validation relied retrospective patient re-diagnosis and/or historical GBMs (hGBMs) controls. Whether pTERT only mGBMs also have a poor prognosis remains uncertain. We comprehensively characterised compared to concurrently diagnosed hGBMs. MATERIAL AND...
This project aimed to improve identification and management of older patients with cognitive impairment on hospital admission. All medical over 65 should have AMTS admission <8 trigger further investigation. admissions aged a 2-week period in
Abstract AIMS We aim to identify circulating prognostic biomarkers that accurately high risk meningioma whilst reducing the burden of invasive diagnostics. In our proteomic analysis, S100A4 and Fibulin-2 are significantly over expressed in grade 2 tumours compared 1. They both calcium-binding proteins with involved mesenchymal transition while helps scaffold extracellular matrix. Elevated levels correlate aggressive phenotypes multiple cancers. METHOD Anonymised pre-operative blood samples...