A5052307086- Cell death mechanisms and regulation
- Neuroblastoma Research and Treatments
- Cleft Lip and Palate Research
- Craniofacial Disorders and Treatments
- Infant Nutrition and Health
- Ubiquitin and proteasome pathways
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Clostridium difficile and Clostridium perfringens research
- interferon and immune responses
- Autophagy in Disease and Therapy
- Viral gastroenteritis research and epidemiology
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Electrolyte and hormonal disorders
- Heart Failure Treatment and Management
- Microtubule and mitosis dynamics
- Endoplasmic Reticulum Stress and Disease
- Family and Patient Care in Intensive Care Units
- Urticaria and Related Conditions
- Infant Development and Preterm Care
- Cardiac Arrest and Resuscitation
- Healthcare Policy and Management
Universitätsmedizin Göttingen
2020-2022
University of Göttingen
2020-2021
Zentrum für Kinderheilkunde
2020
University Medical Centre Mannheim
2013-2017
Heidelberg University
2013-2017
University Hospital Heidelberg
2013-2017
University of Kaiserslautern
2013
Institute of Molecular Biology
2007-2009
Philipps University of Marburg
2007-2008
Universitätsklinikum Gießen und Marburg
2008
The death-inducing signaling complex (DISC) initiates death receptor-induced apoptosis. DISC assembly and activation are controlled by c-FLIP isoforms, which function as pro-apoptotic (c-FLIPL only) or anti-apoptotic (c-FLIPL/c-FLIPS) regulators of procaspase-8 activation. Current models assume that directly competes with for recruitment to FADD. Using a functional reconstituted DISC, structure-guided mutagenesis, quantitative LC-MS/MS, we show c-FLIPL/S binding the is instead co-operative...
MYCN amplification is a common feature of aggressive tumour biology in neuroblastoma. The transcription factor has been demonstrated to induce or repress expression numerous genes. MicroRNAs (miRNA) are recently discovered class short RNAs that translation and promote mRNA degradation by sequence-specific interaction with mRNA. Here, we sought analyse the role regulation miRNA expression. Using microarray containing 384 different miRNAs set 160 real-time PCR assays validate results, 7 were...
Abstract Acquired or intrinsic resistance to apoptotic and necroptotic stimuli is considered a major hindrance of therapeutic success in malignant melanoma. Inhibitor apoptosis proteins (IAPs) are important regulators cell death mediated by numerous signalling platforms. In this report we investigated the impact IAPs for regulation Suppression strongly sensitized panel melanoma cells ligand-induced death, which, surprisingly, was largely apoptosis, as it completely rescued addition caspase...
Oxidation of cysteine residues to disulfides drives import many proteins into the intermembrane space mitochondria. Recent studies in yeast unraveled basic principles mitochondrial protein oxidation, but kinetics under physiological conditions is unknown. We developed assays follow oxidation living mammalian cells, which reveal that and oxidative folding are kinetically functionally coupled depend on oxidoreductase Mia40, sulfhydryl oxidase augmenter liver regeneration (ALR), intracellular...
Formation of the death-inducing signaling complex (DISC) initiates extrinsic apoptosis. Caspase-8 and its regulator cFLIP control death by binding to death-receptor-bound FADD. By elucidating function caspase-8 homolog, caspase-10, we discover that caspase-10 negatively regulates caspase-8-mediated cell death. Significantly, reveal reduces DISC association activation caspase-8. Furthermore, extend our co-operative/hierarchical model caspase-8/cFLIP show does not compete with for Utilizing...
FADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constitutively lack these molecules die at an early embryonic age, whereas tissue-specific constitutive deletion FADD or caspase-8 results in inflammatory skin disease caused by increased necroptosis. The function vivo is unknown. In contrast to knockout, we show mice lacking epidermis around days 10 11. When expression was abrogated adult cFLIPfl/fl-K14CreERtam mice, severe inflammation with concomitant...
Abstract The relevance of the adaptor protein TNF receptor-associated factor 2 (TRAF2) for signal transduction death receptor tumour necrosis receptor1 (TNFR1) is well-established. role TRAF2 signalling by CD95 and TNF-related apoptosis inducing ligand (TRAIL) DRs, however, only poorly understood. Here, we observed that knockdown (KD) sensitised keratinocytes TRAIL- CD95L-induced apoptosis. Interestingly, while cell was fully blocked pan-caspase inhibitor...
AimTo determine whether the use of a respiratory function monitor (RFM) during PPV extremely preterm infants at birth, compared with no RFM, leads to an increase in percentage inflations expiratory tidal volume (Vte) within predefined target range.MethodsUnmasked, randomised clinical trial conducted October 2013 - May 2019 7 neonatal intensive care units 6 countries. Very (24–27 weeks gestation) receiving birth were have RFM screen visible or not. The primary outcome was median proportion...
Abstract Aim The aim of this study was to assess the resuscitators' opinions usefulness and clinical value using a respiratory function monitor (RFM) when resuscitating extremely preterm infants with positive pressure ventilation. Methods link an online survey sent 106 resuscitators from six countries who were involved in multicentre trial that compared percentage inflations within predefined target range without RFM. asked for 4 months after ended May 2019. Results completed by 74 (70%)...
Recent epidemiological studies identifying an association between some classes of gastric acid suppressants and Clostridium difficile colitis community-acquired pneumonia prompted our analysis. Our objective was to retrospectively apply data mining algorithms (DMAs) the Food Drug Administration (FDA) drug safety database see if they might have directed/redirected attention reported suppressive drugs with C. pneumonia, prior published findings that supported association.Two statistical DMAs,...
Head development is a surrogate for brain in infants and related to neurocognitive outcome. There only limited knowledge on early extra-uterine head shape size assessment very preterm infants. Here, 26 with mean gestational age of 29.1 ± 2.2 weeks birth weight 1273.8 427.7 g underwent serial stereophotogrammetric 3D imaging weekly intervals from term-equivalent age. The main outcome was the longitudinal 'physiological' cephalometric (head circumference, cranial volume) parameters (cranial...
Young children are frequently colonized with
Abstract The development of head shape and volume may reflect neurodevelopmental outcome therefore is paramount importance in neonatal care. Here, we compare morphology 25 very preterm infants with a birth weight below 1500 g / or gestational age (GA) before 32 completed weeks to term GA 37–42 at equivalent (TEA) identify possible risk factors for non-synostotic deformities. For three-dimensional assessments, portable stereophotogrammetric device was used. most common distinct deformity...
Incomplete and absent doses in routine childhood vaccinations are of major concern. Health systems low- middle-income countries (LMIC), particular, often struggle to enable full vaccination children, which affects their immunity against communicable diseases. Data on child cards from a cross-sectional primary survey with 1,967 households were used assess the status. The association timely postnatal care (PNC) place delivery any-dose (at least one dose each vaccine) children between 10-20...