A5030615750- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal Transplantation Outcomes and Treatments
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Molecular Biology Techniques and Applications
- Cardiac and Coronary Surgery Techniques
- Viral-associated cancers and disorders
- Flood Risk Assessment and Management
- Acute Kidney Injury Research
- Blood transfusion and management
- Cardiac Valve Diseases and Treatments
- Adipose Tissue and Metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Charité - Universitätsmedizin Berlin
2012-2025
Deutsches Herzzentrum der Charité
2014-2025
German Centre for Cardiovascular Research
2019-2025
Auguste-Viktoria-Klinik
2025
Saarland University
2024
Örebro University
2024
Deutsches Herzzentrum München
2007-2024
University of Tübingen
2023
University of Oxford
2020-2021
Berlin Heart (Germany)
2021
Abstract The science of event attribution has emerged to routinely answer the question whether and what extent human-induced climate change altered likelihood intensity recently observed extreme weather events. In Europe a pilot program operationalize method started in November 2019, highlighting demand for timely information on role when it is needed most: direct aftermath an event. Independent studies are provided operationally or as academic studies, necessity good observational data...
Interstage home monitoring (IHM) programs are considered standard of care after Norwood palliation and have led to substantial improvements in clinical outcomes. This study aims evaluate an application-based remote IHM program for infants with shunt- or duct-dependent pulmonary circulation. The primary goals were discharge from the hospital while minimizing mortality, optimizing somatic growth, enhancing caregivers' confidence management at home. Infants shunt-dependent single ventricle...
Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella®) may improve short-term survival and neurological outcomes in selected patients refractory cardiac arrest. However, long-term effects on cardiac, cognitive, physical psychological health need further study. A multidisciplinary post-ECPR outpatient care program was developed at two centers, involving cardiologists,...
The search for an optimal patch material aortic valve reconstruction (AVR) is ongoing challenge. In this study, we report our experience of AVR using decellularized bovine pericardial in congenital heart surgery. Data 40 consecutive patients who underwent the CardioCel® (Admedus Regen Pty Ltd, Perth, WA, Australia) between February 2014 and August 2016 were retrospectively reviewed. median age at operation was 9 (2–34) years, 18 younger than 7 years. Twenty-six initially presented with...
Despite the widespread interest in clinical applications of hypothermia, cellular mechanisms hypothermia-induced neuroprotection have not yet been clearly understood. Therefore, aim this study was to elucidate effects clinically relevant hypothermia and rewarming on morphological functional characteristics microglia. Microglial cells were exposed a dynamic cooling protocol. For stimulation, microglial treated with 1 microg/mL lipopolysaccharide (LPS). We found that led changes from ramified...
Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest neonatal hypoxia-ischemia. However, despite our clinical experimental experiences, the protective molecular mechanisms of therapeutic remain be elucidated. Therefore, this brief overview we discuss both evidence order provide further insights into intervention.
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy Fallot has been linked with favorable right remodeling but adverse outcomes. The aim our study was to assess the hemodynamic impact and prognostic relevance pressure load in this population. Methods Results A total 296 patients repaired (mean age, 17.8±7.9 years) were included a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain quantified by feature tracking technique at...
Systemic or brain-selective hypothermia is a well-established method for neuroprotection after brain trauma. There increasing evidence that exerts beneficial effects on the and may also support regenerative responses damage. Here, we have investigated whether influences neurite outgrowth in vitro via modulation of post-injury cytokine milieu. Organotypic slices were incubated: deep (2 h at 17 degrees C), rewarming up to 37 normothermia (20 C). Neurite density release (IL 1beta, IL-6, IL-10,...
Therapeutic hypothermia during cardiac surgery has been widely used for neuroprotection and to attenuate the systemic inflammatory response due cardiopulmonary bypass (CPB). Experimental data suggest that cold-shock protein RNA-binding motif 3 (RBM3), which is induced in hypothermia, plays a key role hypothermia-induced organ protection. To date, investigation on RBM3 performed exclusively vitro or animal models, detection regulation of human blood not investigated until now. The aim this...
Management of cardiac arrest patients includes active body temperature control and strict prevention fever to avoid further neurological damage. Cold-shock proteins RNA-binding motif 3 (RBM3) cold inducible protein (CIRP) expressions are induced in vitro response hypothermia play a key role hypothermia-induced neuroprotection.To measure gene RBM3, CIRP, inflammatory biomarkers whole blood samples from targeted management (TTM)-treated post-cardiac for the potential application as clinical...
Objective: Insufficient myocardial protection is still a considerable cause for in-hospital mortality in children. The purpose of our study was to investigate underlying the basic mechanisms cardioplegic cardioprotection during hypothermic and normothermic ischemia cardiomyocyte cell culture model. Methods: We cooled cardiomyocytes 20 °C min; this time, cardiac arrest simulated by oxidative damage with 2 mM H2O2 solution, followed rewarming 37 °C. Later on, we analyzed morphology...
Heart transplantation is a well-established treatment for end-stage heart failure in paediatric patients, demonstrating excellent long-term outcomes.