A5075875108- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant Reproductive Biology
- Hypothalamic control of reproductive hormones
- Mechanical Circulatory Support Devices
- Optical Coherence Tomography Applications
- Biochemical Analysis and Sensing Techniques
- Magnesium in Health and Disease
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- Cardiac Arrest and Resuscitation
- Neurobiology and Insect Physiology Research
- Intensive Care Unit Cognitive Disorders
- Aluminum toxicity and tolerance in plants and animals
- Immune Response and Inflammation
- Neuroendocrine regulation and behavior
- Ion Channels and Receptors
- Plant Micronutrient Interactions and Effects
- Mosquito-borne diseases and control
- Neuroscience and Neuropharmacology Research
- Advanced Biosensing Techniques and Applications
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- Advanced Nanomaterials in Catalysis
Saarland University
2023-2025
Deutsches Herzzentrum der Charité
2025
Charité - Universitätsmedizin Berlin
2025
Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella®) may improve short-term survival and neurological outcomes in selected patients refractory cardiac arrest. However, long-term effects on cardiac, cognitive, physical psychological health need further study. A multidisciplinary post-ECPR outpatient care program was developed at two centers, involving cardiologists,...
Abstract Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a activity-dependent manner. These facilitate exocytosis of lysosomes. A reduction the number or branching reduces these contacts, which is associated lysosome accumulation and altered metabolism neurons more senescent age. similar OPC seen an early-stage mouse model...
Abstract Magnesium is the fourth most abundant cation in human organism. As a key-player many enzymatic reactions, magnesium homeostasis disbalance can cause severe disorders. In early 2000s, transient receptor potential melastatin channel 6 (TRPM6) was identified as critical protein renal Mg 2+ -reabsorption distal convoluted tubule (DCT). key-interface responsible for salt/water adaptation to environmental changes, kidney highly dynamic system. Therefore, TRPM6 expression and might not be...
Abstract Microendoscopy, a crucial technology for minimally invasive investigations of organs, facilitates studies within confined cavities. However, conventional microendoscopy is often limited by probe size and the constraint using single excitation wavelength. In response to these constraints, multichannel microendoscope with slender profile only 360 µm engineered. Functional signals both in situ vivo are successfully captured from individual cells, employing specially developed software...
Abstract The median eminence (ME) is a circumventricular organ at the base of brain that controls body homeostasis. Tanycytes are its specialized glial cells constitute ventricular walls and regulate different physiological states, however individual signaling pathways in these incompletely understood. Here, we identify functional tanycyte subpopulation expresses key taste transduction genes including bitter receptors, G protein gustducin gustatory ion channel TRPM5 (M5). M5 tanycytes have...
Abstract Oligodendrocyte precursor cells (OPCs) shape brain function through intricate regulatory mechanisms. Here, we observed that OPC processes establish connections with neuronal somata, smaller lysosomes positioned near these contact sites. Tracking demonstrated were attracted to and released at points, eventually becoming incorporated into processes, suggesting a selective, OPC-evoked release of from soma their ingestion by OPCs, highlighting unique lysosome-mediated communication...
Abstract Microendoscopy enables minimally invasive investigations of organs even within small cavities. Conventional microendoscopy is limited by probe size and often restricted to a single excitation wavelength. We developed characterized multichannel microendoscope as thin 360 µm recorded functional cellular signals in-situ using custom written software for image processing. The endoscope had an effective resolution 4.64 resolved subcellular structures neurons. system enabled analysis...
By virtue of mitochondrial control energy production, reactive oxygen species (ROS) generation, and maintenance Ca2+ homeostasis, mitochondria play an essential role in modulating T cell function. The uniporter (MCU) is the pore-forming unit main protein complex mediating uptake. Recently, MCU has been shown to modulate signals at subcellular organellar interfaces, thus fine-tuning NFAT translocation activation. mechanisms underlying this modulation whether additional subpopulation-specific...
Gonadotropes in the anterior pituitary gland are essential for fertility and provide a functional link between brain gonads. To trigger ovulation, gonadotrope cells release massive amounts of luteinizing hormone (LH). The mechanism underlying this remains unclear. Here, we utilize mouse model expressing genetically encoded Ca2+ indicator exclusively gonadotropes to dissect intact pituitaries. We demonstrate that female exhibit state hyperexcitability during LH surge, resulting spontaneous...
Abstract Aging is a multifactorial and complex physiological process, affecting every organ with characteristic manifestations. Understanding the molecular mechanisms that drive aging processes crucial to targeting age-related disorders. Recent reports suggest severe post-infection syndromes can partially accelerate aging. However, underlying gene-encoded regulatory interplay, whether being shared or distinct between infection biology are poorly understood. Here, we employed spatial...