A5090331168- Hypothalamic control of reproductive hormones
- Olfactory and Sensory Function Studies
- Ovarian function and disorders
- Brain Metastases and Treatment
- Ocular Surface and Contact Lens
- Neuroendocrine regulation and behavior
- Autism Spectrum Disorder Research
- HER2/EGFR in Cancer Research
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- Cancer Cells and Metastasis
- Sexual function and dysfunction studies
- Family and Disability Support Research
- Down syndrome and intellectual disability research
- Urticaria and Related Conditions
- Biomedical Ethics and Regulation
- Reproductive Biology and Fertility
- Plant Reproductive Biology
- Neuropeptides and Animal Physiology
Université de Lille
2022-2023
Inserm
2022-2023
Centre Hospitalier Universitaire de Lille
2022-2023
Lille Neurosciences & Cognition
2022-2023
Centre de Recherche Jean Pierre Aubert
2023
European Genomic Institute for Diabetes
2022
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel postpubertal decrease hypothalamic as well extrahypothalamic expression of master molecule controls reproduction-gonadotropin-releasing hormone (GnRH)-and appear related to an imbalance microRNA-gene network known regulate GnRH neuron maturation together with altered...
Brief summary: This study identified a new role for GnRH in higher brain function using rodent model of Down Syndrome. It reports the first time an improvement cognitive functions patients with Syndrome treated pulsatile GnRH.
Women with polycystic ovary syndrome (PCOS) frequently experience decreased sexual arousal, desire, and satisfaction. While the hypothalamus is known to regulate behavior, specific neuronal pathways affected in patients PCOS are not known. To dissect underlying neural circuitry, we capitalized on a robust preclinical animal model that reliably recapitulates all cardinal features. We discovered female mice prenatally treated anti-Müllerian hormone (PAMH) display impaired behavior partner...
SummaryBackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder leading to anovulatory infertility. Abnormalities in central neuroendocrine system governed by gonadotropin-releasing hormone (GnRH) neurons might be related ovarian dysfunction PCOS, although link this disordered brain-to-ovary communication remains unclear. Here, we manipulated GnRH using chemogenetics adult female mice unveil whether chronic overaction of these would trigger PCOS-like hormonal and...
Abstract Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition reducing survival. The development metastases harmful triple-negative breast cancer (TNBC). To date, mechanisms that induce TNBC are poorly understood. Methods Using human blood–brain barrier (BBB) vitro model, an 3D organotypic extracellular matrix, ex vivo mouse slices co-culture xenograft experiment,...
Abstract Hypothalamic gonadotropin-releasing hormones (GnRH) neurons are central regulators of fertility and integrate endogenous hormonal status with environmental cues to ensure reproductive success. Here, we found that a novel population extra-hypothalamic GnRH in the olfactory bulb adult mice humans (GnRH OB ) can mediate social recognition. We show extend neurites into vomeronasal organ epithelium project hypothalamic median eminence. demonstrate male neuronsexpress chemosensory...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Disclosure: E.G. Mills: None. M. Swedrowska: V. Delli: K. Chachlaki: Silva: L. Decoster: G. Ternier: Thurston: Phylactou: B. Patel: Yang: S.A. Clarke: Muzi: E.C. Alexander: Choudhury: P. Bech: A. Abbara: Forbes: Giacobini: Prevot: A.N. Comninos: W.S. Dhillo: Background: Kisspeptin is a key regulator of hypothalamic GnRH neurons with emerging potential to treat reproductive, psychosexual and bone disorders. However, current therapeutic application limited the subcutaneous or...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)