A5038377474- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Plant Reproductive Biology
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Adrenal Hormones and Disorders
- Menstrual Health and Disorders
- Eating Disorders and Behaviors
- Adrenal and Paraganglionic Tumors
- Ocular Surface and Contact Lens
- Thyroid Disorders and Treatments
- Neuroendocrine regulation and behavior
- Urticaria and Related Conditions
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Evolutionary Psychology and Human Behavior
- Sexual Differentiation and Disorders
- Pharmacology and Obesity Treatment
- Pituitary Gland Disorders and Treatments
- Thermal Regulation in Medicine
- Thyroid and Parathyroid Surgery
- Reproductive System and Pregnancy
- Neuroendocrine Tumor Research Advances
Imperial College London
2018-2025
Imperial College Healthcare NHS Trust
2016-2025
Hammersmith Hospital
2018-2023
American Society for Investigative Pathology
2022
National Health Service
2020
McMaster University
2018
University of Rwanda
2018
St. Mary’s Hospital
2016
London Postgraduate Medical and Dental Education
2015
Abstract Context The effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with both thyrotoxicosis and suppression function reported. Objective We aimed to detail acute determine if these persisted recovery from COVID-19. Design A cohort observational study was conducted. Participants Setting Adult patients admitted Imperial College Healthcare National Health Service Trust, London, UK, suspected between March 9 April 22, 2020, were included,...
BACKGROUNDKisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and essential for reproductive health. A specific kisspeptin receptor (KISS1R) agonist could significantly expand the potential clinical utility therapeutics targeting pathway. Herein, we investigate effects KISS1R agonist, MVT-602, in healthy women with disorders.METHODSWe conducted vivo vitro studies to characterize action MVT-602 comparison native kisspeptin-54 (KP54). We determined...
Abstract Context The COVID-19 pandemic continues to exert an immense burden on global health services. Moreover, up 63% of patients experience persistent symptoms, including fatigue, after acute illness. Endocrine systems are vulnerable the effects as many glands express ACE2 receptor, used by SARS-CoV-2 virion for cellular access. However, adrenal and thyroid gland function remain unknown. Objective Our objectives were evaluate in survivors. Methods A prospective, observational study was...
Abstract Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity pulsatile GnRH secretion. Their critical role in health was first identified after inactivating variants genes encoding for KP or NKB signaling were shown to result congenital hypogonadotropic hypogonadism a failure of pubertal development. Over past 2 decades since their discovery, wealth...
We have recently demonstrated a causal link between loss of gonadotropin-releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive deficits during pathological aging, including Down syndrome Alzheimer's disease. Olfactory alterations, which persist in some COVID-19 patients, long-term hypotestosteronaemia SARS-CoV-2-infected men are also reminiscent consequences deficient GnRH, suggesting that GnRH system neuroinvasion could underlie certain post-COVID symptoms...
Importance The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low desire; most prevalent psychological form hypoactive desire disorder (HSDD), which affects 8% men but currently has no effective pharmacological treatment options. reproductive neuropeptide kisspeptin offers a putative therapeutic target, owing emerging understanding its role in behavior. Objective To determine...
Reproductive success and ultimately species survival at a population level is contingent on plethora of neuroendocrine signals working in concert to regulate gonadal function reproductive behavior. Among these, the neuropeptide kisspeptin (encoded by KISS1/Kiss1 gene) has emerged as master regulator hypothalamic-pituitary-gonadal axis. Besides hypothalamus, both its cognate receptor are extensively expressed throughout cortico-limbic brain structures rodents humans, which regions...
Kisspeptin is a critical endogenous activator of the reproductive system, with escalating clinical interest as novel therapeutic for common and psychosexual disorders. However, conflicting animal data suggest that kisspeptin can have anxiolytic, neutral, or anxiogenic effects. Given rapid development kisspeptin-based therapeutics, it important to comprehensively investigate kisspeptin's effects on anxiety in humans. Ninety-five participants (N=63 male, N=32 female) completed double-blind,...
• Glucocorticoids are commonly used drugs in the inpatient and outpatient settings.• Their use can cause steroid-induced hyperglycaemia diabetes.• High-risk patients for steroid...
Osteoporosis results from disturbances in bone formation and resorption. Recent nonhuman data suggest that the reproductive hormone kisspeptin directly stimulates osteoblast differentiation vitro thus could have clinical therapeutic potential. However, effects of on human metabolism are currently unknown.To assess vivo.In study: Mono- cocultures osteoblasts osteoclasts treated with kisspeptin. Clinical Randomized, placebo-controlled, double-blind, 2-way crossover study 26 men investigating...
Successful reproduction is a fundamental physiological process that relies on the integration of sensory cues attraction with appropriate emotions and behaviors reproductive axis. However, factors responsible for this remain largely unexplored. Using functional neuroimaging, hormonal, psychometric analyses, we demonstrate hormone kisspeptin enhances brain activity in response to olfactory visual men. Furthermore, regions enhanced by correspond areas within limbic systems govern sexual...
Importance Despite being the most common female sexual health complaint worldwide, current treatment options for hypoactive desire disorder (HSDD) are limited in their safety and effectiveness. The hormone kisspeptin is a key endogenous activator of reproductive hormonal axis with additional emerging roles emotional behavior; however, its effects women HSDD unknown. Objective To test hypothesis that enhances attraction brain processing HSDD. Design, Setting, Participants This randomized...
Abstract Distressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects approximately 10% of women and 8% men. In women, the ‘top-down’ theory HSDD describes hyperactivity in higher-level cognitive brain regions, suppressing lower-level emotional/sexual areas. However, it is unknown how this neurofunctional disturbance compares to To investigate this, we employed task-based functional MRI 32 men with measure sexual-brain processing during versus non-sexual videos, as...
To compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone in combination, as biomarkers for miscarriage throughout first trimester.Prospective, nested case-control study.Tertiary Centre, Queen Charlotte Hospital, London, United Kingdom.Adult women who had miscarriages (n = 95, 173 samples) with healthy pregnancies 265, 557 samples).The participants underwent serial ultrasound scans blood sampling measurement plasma βhCG levels during trimester.The...
BACKGROUNDHypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of fantasies and for activity, causing marked distress interpersonal difficulty. It the most prevalent female health problem globally, affecting approximately 10% women, but has limited treatment options. Melanocortin 4 receptor (MC4R) agonists have emerged as promising therapy women with HSDD, through unknown mechanisms. Studying pathways involved crucial our understanding normal abnormal...
Abstract Context The hormone kisspeptin has crucial and well-characterized roles in reproduction. Emerging data from animal models also suggest that important metabolic effects including modulation of food intake. However, to date there have been no studies exploring the on brain responses stimuli humans. Objective This work aims investigate administration visual psychometric parameters appetite, healthy men. Design A double-blinded, randomized, placebo-controlled, crossover study was...
Glucagon-like peptide-1 (GLP-1) potently reduces food intake and augments glucose-stimulated insulin secretion. Recent animal data suggest that GLP-1 may also influence reproduction. As receptor agonists are currently widely used in clinical practice to treat obesity/type 2 diabetes, it is necessary determine the effects of on reproductive system humans.To investigate administration axis humans.Single-blind, randomized, placebo-controlled crossover study.Clinical Research Facility, Imperial...
Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter that has been implicated in the aetiology of common mood and behavioural disorders. By employing proton magnetic resonance spectroscopy man, we demonstrate administration reproductive neuropeptide, kisspeptin, robustly decreases GABA levels limbic system human brain; specifically anterior cingulate cortex (ACC). This finding defines novel kisspeptin-activated pathway provides important mechanistic insights into...