A5103056307- Metabolomics and Mass Spectrometry Studies
- Hormonal Regulation and Hypertension
- Bioinformatics and Genomic Networks
- Advanced Proteomics Techniques and Applications
- Receptor Mechanisms and Signaling
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Oil Spill Detection and Mitigation
- Analytical Chemistry and Chromatography
- Gastrointestinal motility and disorders
- Diabetes Management and Education
- Sodium Intake and Health
- Mass Spectrometry Techniques and Applications
- Automotive and Human Injury Biomechanics
- Celiac Disease Research and Management
- Congenital Heart Disease Studies
- Orthopedic Surgery and Rehabilitation
- Bone health and treatments
- Graphene and Nanomaterials Applications
- Coronary Artery Anomalies
- Congenital heart defects research
- Marine Toxins and Detection Methods
- Facilities and Workplace Management
- Ergonomics and Musculoskeletal Disorders
- Coronary Interventions and Diagnostics
Pacific Northwest National Laboratory
2019-2025
Battelle
2023-2025
Imperial College London
2020-2024
University of Virginia
2023
University of West Florida
2023
Newcastle University
2017
University of Edinburgh
2002-2015
The Queen's Medical Research Institute
2015
Anne Arundel Medical Center
2008
Brock University
2003
BACKGROUNDKisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neurons and essential for reproductive health. A specific kisspeptin receptor (KISS1R) agonist could significantly expand the potential clinical utility therapeutics targeting pathway. Herein, we investigate effects KISS1R agonist, MVT-602, in healthy women with disorders.METHODSWe conducted vivo vitro studies to characterize action MVT-602 comparison native kisspeptin-54 (KP54). We determined...
The pmartR (https://github.com/pmartR/pmartR) package was designed for the quality control (QC) and analysis of mass spectrometry data, tailored to specific characteristics proteomic (isobaric or labeled), metabolomic, lipidomic data sets. Since its initial release, tool has been expanded address needs growing userbase now includes QC statistics nuclear magnetic resonance metabolomic leverages DESeq2, edgeR, limma-voom R packages transcriptomic analyses. These improvements have made progress...
This study evaluated the hypothesis that upper extremity function and range of motion can be quantified reliably in children with cerebral palsy (CP) a busy clinical setting. The specific aim was to determine inter‐ intrarater reliability modified House Functional Classification (MHC) system evaluate standardized instrument document (Upper Extremity Rating Scale [UERS]). Sixty‐five CP (43 males, 22 females, mean age 9y 2mo, SD 4y 1mo) spasticity involving (quadriplegia n =22; hemiplegia =36;...
The National Microbiome Data Collaborative (NMDC) Portal (https://data.microbiomedata.org) supports microbiome multi-omics data exploration and access through an integrated, distributed framework aligned with the FAIR (Findable, Accessible, Interoperable Reusable) principles (1). NMDC currently hosts 10.2 terabytes of data, spanning five types (metagenomes, metatranscriptomes, metaproteomes, metabolomes, natural organic matter characterizations), generated at two Department Energy User...
Abstract Background Microbiomes contribute to multiple ecosystem services by transforming organic matter in the soil. Extreme shifts environment, such as drying-rewetting cycles during drought, can impact microbial metabolism of altering physiology and function. These physiological responses are mediated part lipids that responsible for regulating interactions between cells environment. Despite this critical role response stress, little is known about metabolites soil or how they influence...
Studies generating transcriptomics, proteomics, lipidomics, and metabolomics (colloquially referred to as "omics") data allow researchers find biomarkers or molecular targets understand complex biological structures functions by identifying changes in biomolecule abundance expression between experimental conditions. Omics are multidimensional, oftentimes summarization techniques such principal component analysis (PCA) used identify high-level patterns data. Though useful, these summaries do...
Investigations of the relationships between crude oil and bacterioplankton have provided clues into how constituents are degraded, anthropogenic spills affect system nutrient cycling food webs. The Deepwater Horizon spill in 2010 re-invigorated investigation marine bacteria respond to spills. While much historical research initial efforts focused on biodegradation oil, it became quickly apparent that bacterial community was affected negatively by oil. Environmental conditions often altered...
Abstract The arterial roots are important transitional regions of the heart, connecting intrapericardial components aortic and pulmonary trunks with their ventricular outlets. They house (semilunar) valves and, in case aorta, points coronary attachment. Moreover, because semilunar attachments valve leaflets, span anatomic ventriculo‐arterial junction. By virtue this arrangement, interleaflet triangles, despite being fibrous, found on aspect root located within left cavity. Malformations...
We have investigated the possibility that abnormally decreased gall bladder contraction after meals in patients with coeliac disease might result part from an abnormality response to endogenous cholecystokinetic hormones--for example, cholecystokinin and motilin--rather than solely secretion of such hormones. Eight untreated nine controls received intravenous infusions pure synthetic analogue caerulein, 2-16 ng/kg/hour. Gall emptying was measured on a minute-by-minute basis using 99mTc-HIDA...
Mass spectrometry is a powerful tool for identifying and analyzing biomolecules such as metabolites lipids in complex biological samples. Liquid chromatography gas mass studies quite commonly involve large numbers of samples, which can require significant time sample preparation analyses. To accommodate studies, the samples are split into batches. Inevitably, variations handling, temperature fluctuation, imprecise timing, column degradation, other factors result systematic errors or biases...
PMart is a web-based tool for reproducible quality control, exploratory data analysis, statistical and interactive visualization of 'omics data, based on the functionality pmartR R package. The newly improved user interface supports more types, additional capabilities, enhanced options creating downloadable graphics. analysis label-free isobaric-labeled (e.g., TMT, iTRAQ) proteomics, nuclear magnetic resonance (NMR) mass-spectrometry (MS)-based metabolomics, MS-based lipidomics, ribonucleic...
Disparities in injury tolerance and kinematic response remain understudied despite field data highlighting sex-based differences risk. Furthermore, the automotive industry anticipates occupants will prefer reclined seating highly automated vehicles. This study aimed to compare thoracolumbar spine kinematics injuries between mid-size female male post-mortem human subjects (PMHS) frontal impacts. Seven adult PMHS (three female, four male) were tested (50°) 50 km/h The seated on a semi-rigid...
Summary Cellular signaling by membrane G protein-coupled receptors (GPCRs) is orchestrated a complex and diverse array of mechanisms. The dynamics GPCR interactome as it evolves over time space in response to an agonist can offer unique window on pleiotropic decoding functional selectivity at cellular level. In this study, we employed proximity-based APEX2 proteomics interrogate the interaction network for luteinizing hormone (LHR) sub-minute timescale. We developed analytical approach...
Cellular signaling by membrane G protein-coupled receptors (GPCRs) is orchestrated a complex and diverse array of mechanisms. The dynamics GPCR interactome as it evolves over time space in response to an agonist can offer unique window on pleiotropic decoding functional selectivity at cellular level. In this study, we employed proximity-based APEX2 proteomics interrogate the interaction network for luteinizing hormone (LHR) sub-minute timescale. We developed analytical approach integrating...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)