A5047090022- Sexual function and dysfunction studies
- Hypothalamic control of reproductive hormones
- Hormonal and reproductive studies
- Neuroendocrine regulation and behavior
- Eating Disorders and Behaviors
- Evolutionary Psychology and Human Behavior
- Sexual Differentiation and Disorders
- Sexuality, Behavior, and Technology
- Menstrual Health and Disorders
- Cholesterol and Lipid Metabolism
- Dermatology and Skin Diseases
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Adolescent Sexual and Reproductive Health
- Regulation of Appetite and Obesity
Imperial College London
2022-2024
American Society for Investigative Pathology
2022
Importance The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low desire; most prevalent psychological form hypoactive desire disorder (HSDD), which affects 8% men but currently has no effective pharmacological treatment options. reproductive neuropeptide kisspeptin offers a putative therapeutic target, owing emerging understanding its role in behavior. Objective To determine...
Importance Despite being the most common female sexual health complaint worldwide, current treatment options for hypoactive desire disorder (HSDD) are limited in their safety and effectiveness. The hormone kisspeptin is a key endogenous activator of reproductive hormonal axis with additional emerging roles emotional behavior; however, its effects women HSDD unknown. Objective To test hypothesis that enhances attraction brain processing HSDD. Design, Setting, Participants This randomized...
Abstract Distressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects approximately 10% of women and 8% men. In women, the ‘top-down’ theory HSDD describes hyperactivity in higher-level cognitive brain regions, suppressing lower-level emotional/sexual areas. However, it is unknown how this neurofunctional disturbance compares to To investigate this, we employed task-based functional MRI 32 men with measure sexual-brain processing during versus non-sexual videos, as...
BACKGROUNDHypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of fantasies and for activity, causing marked distress interpersonal difficulty. It the most prevalent female health problem globally, affecting approximately 10% women, but has limited treatment options. Melanocortin 4 receptor (MC4R) agonists have emerged as promising therapy women with HSDD, through unknown mechanisms. Studying pathways involved crucial our understanding normal abnormal...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Disclosure: E.G. Mills: None. L. Thurston: Yang: S. Suladze: T. Hunjan: M. Phylactou: B. Patel: S.A. Clarke: A.J. Shah: C. Izzi-Engbeaya: J. Tsoutsouki: P. Bech: N. Ertl: Demetriou: M.B. Wall: D. Goldmeier: A. Abbara: A.N. Comninos: W.S. Dhillo: Background: The neuropeptide kisspeptin is a critical endogenous activator of the reproductive system. Due to its key role in regulating and behavioural processes, there has been escalating interest targeting kisspeptin-pathways treat...
Abstract Disclosure: J. Tsoutsouki: None. N. Ertl: E.G. Mills: M.B. Wall: L. Thurston: Yang: S. Suladze: T. Hunjan: M. Phylactou: B. Patel: Howard: A. Abbara: D. Golmeier: A.N. Comninos: W.S. Dhillo: Background: Distressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects 10% of women and 8% men. The established ‘top-down’ neurofunctional model HSDD in suggests that response to erotic cues, excessive activation higher-level cognitive brain regions (involved...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Introduction Sexual desire is a key component of the sexual response model. Absence or deficiency can lead to marked distress interpersonal difficulty, termed 'hypoactive disorder' (HSDD). HSDD most common female health complaint worldwide, affecting 10% women. Despite its detrimental impact on psychological well-being and quality life, treatment options are currently limited. The hormone kisspeptin endogenous activator reproductive endocrine axis, with emerging roles in emotional...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Introduction Hypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of fantasies and for activity, causing marked distress or interpersonal difficulty. It the most prevalent female health problem worldwide, affecting approximately 1 in 10 women, but has limited treatment options despite its substantial health, social, economic burden. Melanocortin-4 receptor (MC4R) agonists have emerged as promising therapy women with HSDD, although, to date, their...
Abstract Background Hypoactive Sexual Desire Disorder (HSDD) is associated with dysfunctional brain activation in regions governing sexual responses, resulting a deficiency or absence of desire marked distress. It major clinical importance given it affects 8% men detrimental effects on quality life, interpersonal relationships and fertility, but so far has no licensed treatment options. The reproductive neuropeptide kisspeptin offers putative therapeutic target owing to its emerging role...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)