A5049653710- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Neuroendocrine regulation and behavior
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Regulation of Appetite and Obesity
- Assisted Reproductive Technology and Twin Pregnancy
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Sexual function and dysfunction studies
- Pregnancy and preeclampsia studies
- Olfactory and Sensory Function Studies
- Birth, Development, and Health
- Plant Reproductive Biology
- Advanced Neuroimaging Techniques and Applications
- Electrolyte and hormonal disorders
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- Estrogen and related hormone effects
- Tryptophan and brain disorders
- Family and Disability Support Research
- Photoreceptor and optogenetics research
- Kawasaki Disease and Coronary Complications
- Menopause: Health Impacts and Treatments
Université de Lille
2020-2024
Inserm
2020-2024
Centre Hospitalier Universitaire de Lille
2020-2024
Lille Neurosciences & Cognition
2019-2024
Centre de Recherche Jean Pierre Aubert
2023-2024
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
European Genomic Institute for Diabetes
2022
University of Otago
2018-2021
Silva
2012-2016
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel postpubertal decrease hypothalamic as well extrahypothalamic expression of master molecule controls reproduction-gonadotropin-releasing hormone (GnRH)-and appear related to an imbalance microRNA-gene network known regulate GnRH neuron maturation together with altered...
Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical animal models suggests that elevated perinatal androgens can elicit PCOS onset in adulthood, implying androgen actions both ontogeny adult pathophysiology. Prenatally androgenized (PNA) mice exhibit robust increase progesterone-sensitive GABAergic inputs to gonadotropin-releasing hormone (GnRH) neurons implicated the pathogenesis PCOS. It...
Angiotensin-converting enzyme 2 (ACE2) knockout is associated with reduced fetal weight at late gestation; however, whether uteroplacental vascular and/or hemodynamic disturbances underlie this growth-restricted phenotype unknown. Uterine artery reactivity and flow velocities, umbilical trophoblast invasion, placental hypoxia were determined in ACE2 (KO) C57Bl/6 wild-type (WT) mice day 14 of gestation. Although systolic blood pressure was higher pregnant KO vs. WT (102.3 ± 5.1 85.1 1.9 mmHg,...
Previously, we reported that chronic activation of the estrogen receptor GPR30 by its selective agonist G-1 decreases blood pressure in ovariectomized hypertensive mRen2.Lewis (mRen2) rats but not intact male littermates. Furthermore, relaxes female mesenteric resistance arteries via both endothelium-dependent and -independent mechanisms. Because lack a pressure-lowering effect males potential influence aging on expression, hypothesized GPR30-dependent vasodilation expression are altered...
Chronic stress exerts multiple negative effects on the physiology and health of an individual. In present study, we examined hypothalamic, pituitary endocrine responses to 14 days chronic variable (CVS) in male female C57BL/6J mice. both sexes, CVS induced a significant decrease body weight enhanced acute corticosterone response, which was accompanied by reduction thymus only females. However, single-point blood measurements basal prolactin, thyroid-stimulating hormone, luteinising growth...
Women with polycystic ovary syndrome (PCOS) frequently experience decreased sexual arousal, desire, and satisfaction. While the hypothalamus is known to regulate behavior, specific neuronal pathways affected in patients PCOS are not known. To dissect underlying neural circuitry, we capitalized on a robust preclinical animal model that reliably recapitulates all cardinal features. We discovered female mice prenatally treated anti-Müllerian hormone (PAMH) display impaired behavior partner...
SummaryBackgroundPolycystic ovary syndrome (PCOS) is the most common endocrine disorder leading to anovulatory infertility. Abnormalities in central neuroendocrine system governed by gonadotropin-releasing hormone (GnRH) neurons might be related ovarian dysfunction PCOS, although link this disordered brain-to-ovary communication remains unclear. Here, we manipulated GnRH using chemogenetics adult female mice unveil whether chronic overaction of these would trigger PCOS-like hormonal and...
We describe a patient who developed neuralgic amyotrophy (NA) related to hepatitis E virus (HEV) infection.The underwent neurological and electrodiagnostic examinations, high-resolution analysis of serological changes, HEV load profile, was treated with intravenous immunoglobulin.There evidence bilateral, asymmetric acute inflammatory cervical polyradiculopathy possible brachial plexopathy. Positive serum anti-HEV IgM followed by seroconversion IgG positivity. A calculated antibody index...
The primary objective of the present study women participating in an ICSI program was to determine whether morphologic quality oocytes related polycystic ovary syndrome (PCOS) phenotype.We performed a retrospective cohort IVF unit at Lille University Medical Center (Lille, France) between 2006 and 2015. Oocyte morphology (fragmented first polar body, abnormal zona pellucida, large perivitelline space, material shape oocyte, granular cytoplasm intracytoplasmic vacuoles) evaluated PCOS...
Polycystic ovary syndrome (PCOS) is a major endocrine disorder strongly associated with androgen excess and frequently leading to female infertility. Although classically considered an ovarian disease, altered neuroendocrine control of gonadotropin-releasing hormone (GnRH) neurons in the brain abnormal gonadotropin secretion may underpin PCOS presentation. Defective regulation GnRH pulse generation promotes high luteinizing (LH) pulsatile secretion, which turn overstimulates production....
Abstract Hypothalamic gonadotropin-releasing hormones (GnRH) neurons are central regulators of fertility and integrate endogenous hormonal status with environmental cues to ensure reproductive success. Here, we found that a novel population extra-hypothalamic GnRH in the olfactory bulb adult mice humans (GnRH OB ) can mediate social recognition. We show extend neurites into vomeronasal organ epithelium project hypothalamic median eminence. demonstrate male neuronsexpress chemosensory...
Sexual health is considered of fundamental importance in people’s lives. Since it determined by physiological, psychological and social factors, the investigations these aspects are relevant to full comprehension this phenomenon. Endocrinological conditions, as overweighed normal body mass indexes were addressed main factors women’ sexual function, which can affect level hormones; a consequence, lead dysfunction. Body index 370 women analyzed indentify implications their life, using Female...
Abstract Disclosure: S.T. Zdon: None. M.S. Silva: V.M. Navarro: Kisspeptin (Kiss1) neurons are essential for reproductive function as they strong regulators of the hypothalamic-pituitary-gonadal axis (HPG). Mammalian Kiss1 mainly located in hypothalamus, controlling gonadotropin-releasing hormone (GnRH) secretion, where anteroventral periventricular nucleus (AVPV) population is morphologically and functionally sexually differentiated. also found limbic areas, such bed stria terminalis...
Abstract Disclosure: E.G. Mills: None. M. Swedrowska: V. Delli: K. Chachlaki: Silva: L. Decoster: G. Ternier: Thurston: Phylactou: B. Patel: Yang: S.A. Clarke: Muzi: E.C. Alexander: Choudhury: P. Bech: A. Abbara: Forbes: Giacobini: Prevot: A.N. Comninos: W.S. Dhillo: Background: Kisspeptin is a key regulator of hypothalamic GnRH neurons with emerging potential to treat reproductive, psychosexual and bone disorders. However, current therapeutic application limited the subcutaneous or...
We previously reported that chronic activation of estrogen receptor GPR30 by the selective agonist G-1 decreases blood pressure in ovariectomized hypertensive mRen2.Lewis rats but not male littermates. Furthermore, acute relaxes female mesenteric resistance arteries via both endothelium-dependent and -independent mechanisms. Because lack a pressure-lowering effect males because aging may influence expression, we hypothesized GPR30-dependent vasodilation was reduced older females. Mesenteric...