A5076905564- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Ovarian function and disorders
- Adipose Tissue and Metabolism
- Reproductive System and Pregnancy
- Menopause: Health Impacts and Treatments
- Birth, Development, and Health
- Heart Failure Treatment and Management
- Trypanosoma species research and implications
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Reproductive Biology and Fertility
- Neuroendocrine regulation and behavior
- Cardiovascular Issues in Pregnancy
- Electrolyte and hormonal disorders
- Hormonal and reproductive studies
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
Universidade Federal de Minas Gerais
2013-2023
Universidade Federal de Ouro Preto
2011
Institute of Molecular Biology and Biophysics
2011
National Council for Scientific and Technological Development
2007-2009
Montreal Clinical Research Institute
2007
The University of Texas Health Science Center at San Antonio
2007
Universidade dos Açores
2006
Université de Montréal
1997-1999
The University of Texas Southwestern Medical Center
1999
Hôtel-Dieu de Montréal
1995-1997
Prolactin (PRL) is known to suppress LH secretion. Kisspeptin neurons regulate secretion and express PRL receptors. We investigated whether acts on kisspeptin in lactating (Lac) virgin rats. Lac rats displayed high reduced plasma immunoreactivity the arcuate nucleus (ARC). Bromocriptine-induced blockade significantly increased ARC levels but did not restore them of non-Lac Bromocriptine effects were prevented by coadministration ovine (oPRL). Virgin ovariectomized (OVX) treated with either...
Several studies have shown the presence of components renin–angiotensin system in mammalian ovaries and their involvement ovarian physiology. We previously angiotensin‐(1–7) [Ang‐(1–7)], an important biologically active component system, its receptor, Mas, rat, rabbit human ovaries. also Ang‐(1–7) ovulatory process vitro . In present study, we observed that stimulated resumption meiosis oocytes rat preovulatory follicles, reaching more than 30% with germinal vesicle breakdown. The specific...
Maternal malnutrition during lactation programmes for overweight and central leptin resistance in adulthood. The inhibition of by maternal treatment with bromocriptine (a prolactin inhibitor) obesity, hyperleptinaemia resistance. Here, we evaluated the short- long-term effects early weaning (EW) on body-weight regulation, signalling, hormone lipid profiles rats offspring. Lactating were separated into two groups: EW – dams wrapped a bandage to interrupt last 3 d lactation; control whose pups...
We have shown that maternal nicotine exposure during lactation has long-lasting effects on body adiposity and hormonal status of rat offspring. Here, we studied the nutritional profiles in this experimental model. Two days after birth, osmotic minipumps were implanted lactating rats divided into two groups: NIC - continuous s.c. infusions (6 mg/kg per day) for 14 C saline. Dams pups killed at 15 21 lactation. Body weight food intake evaluated. Milk, blood, visceral fat, carcass, adrenal...
The objective of this study was to characterize the profiles Ang-(1-7), MAS receptor, ACE 2 , NEP and PEP during ovulatory process in cattle. For study, 40 synchronized cows with follicular diameter ≥ 12 mm were ovariectomized at different time-points (0, 3, 6, 24 h) after i.m. application gonadotropin-releasing hormone (GnRH) induce a luteinizing surge. Follicular fluid collected for measuring Ang-(1-7) by radioimmunoassay. Theca granulosa cells isolated from preovulatory follicles evaluate...
A local renin–angiotensin system has been described in several organs, including the ovary; however, data indicating a role for angiotensin II induction of ovulation are controversial. We have previously shown presence novel peptide, angiotensin-(1–7) [Ang-(1–7)], rat ovary and its effect on steroidogenesis. The objective present study was to determine whether Ang-(1–7) plays ovulation. first determined distribution receptor Mas rabbit ovaries by immunohistochemistry. Angiotensin-(1–7)...
Do angiotensin (Ang)-(1–7) levels in human ovarian follicular fluid (FF) correlate with the number and proportion of mature oocytes obtained for IVF? The present study shows first time that Ang-(1–7) FF collected upon stimulation IVF. is an active peptide renin-angiotensin system stimulates oocyte maturation isolated rabbit rat ovaries. However, its role ovulation remains unexplored. This was a prospective cohort including 64 participants from single IVF center. Sample size calculated to...
We have recently described a new peptide of the renin-angiotensin system, alamandine, derivative angiotensin-(1-7). Mas-related G protein-coupled receptor member D (MrgD) was identified as its receptor. Although similar cardioprotective effects alamandine to those angiotensin-(1-7) been described, significance this in heart function is still elusive. aimed evaluate functional role MrgD using MrgD-deficient mice. localized cardiomyocytes by immunofluorescence confocal microscopy....
We have previously shown that rat ovaries synthesize atrial natriuretic peptide (ANP) and express the cognate guanylyl cyclase (GC-A GC-B) receptors for ANP. Since another peptide, termed C-type (CNP), can also interact with these receptors, we investigated whether CNP if so, concentration of this guanylyl-cyclase are influenced by estrous cycle.
The present study was undertaken to investigate the presence of angiotensin-(1–7) [Ang-(1–7)] in ovary and a possible role for it. Cycling female rats were killed each phase estrous cycle, ovarian Ang II Ang-(1–7) separated by HPLC measured RIA. mean levels proestrus estrus significantly higher than those metestrus diestrus (P < 0.05). also equine chorionic gonadotropin (eCG)-treated immature rats. induced significant increase estradiol progesterone production 0.05) (24–25 d old) pretreated...
Abstract Background Fluid homeostasis is critical for normal function of the male reproductive tract and aquaporins (AQP) play an important role in maintenance this water ion balance. Several AQPs have been identified male, but their regulation not fully comprehended. Hormonal appears to be dependent on steroid region. AQP9 displays unique hormonal efferent ductules epididymis, as it regulated by both estrogen dihydrotestosterone (DHT) ductules, only DHT initial segment epididymis. Recent...
Neonatal malnutrition is associated with metabolic syndrome in adulthood. Maternal hypoprolactinaemia at the end of lactation (a precocious weaning model) caused obesity, leptin resistance and hypothyroidism adult offspring, suggesting an association prolactin (PRL) programming dysfunctions. Metabolic pathogenesis still unclear, but abdominal higher triglycerides, lower high-density lipoprotein (HDL-c) insulin have been proposed to be important factors involved. We studied consequences...
Malnutrition during lactation is associated with hypoprolactinemia and failure in milk production. Adult rats whose mothers were malnourished presented higher body weight serum tri-iodothyronine (T 3 ). Maternal at the end of caused adult life, suggesting an association between maternal prolactin (PRL) level programming offspring's weight. Here, we studied consequences PRL inhibition by bromocriptine (BRO) injection, a dopaminergic agonist, upon TSH thyroid hormones, iodide uptake, liver...
Angiotensin II (AngII) has a role in ovarian follicle development, ovulation, and oocyte meiotic resumption. The objective of the present study was to characterise AngII profile mRNA encoding RAS proteins bovine follicular wave. Cows were ovariectomised when size between largest (F1) second (F2) not statistically different (day 2), slightly 3), or markedly 4). measured fluid abundance genes angiotensin-converting enzyme (ACE), (pro)renin receptor, renin-binding protein (RnBP) evaluated cells...
Kisspeptin (Kp) regulates prolactin (PRL) in an estradiol-dependent manner. We investigated the interaction between ovarian steroid receptors and Kp control of PRL secretion. Intracerebroventricular injections Kp-10 or Kp-234 were performed ovariectomized (OVX) rats under different hormonal treatments. increased release decreased 3,4-dihydroxyphenylacetic acid levels median eminence (ME) OVX treated with estradiol (OVX+E), which was prevented by tamoxifen. Whereas these effects absent rats,...
Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD order determine role of autonomic modulation and left ventricular dysfunction incompetence. Methods: ambulatory (n = 170) healthy controls 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic...
Malnutrition during lactation reduces milk production and changes pup's leptin serum levels. To test prolactin role in this nutritional state, we evaluated whether suppression dams, its transfer through the milk, leptin. Lactating rats were treated with bromocryptine (1 mg/twice a day, sc) or saline three days before sacrifice (days 2 - 4 19 21). Food intake body weight measured until (4th 21st day). Serum determined by radioimmunoassay. Bromocryptine injected dams had lower as expected. The...
Exposure to tobacco smoke is related changes in energy balance regulation and several endocrine dysfunctions. Previously, we showed that maternal nicotine (the main addictive compound of tobacco) exposure exclusively during lactation affects biochemical profiles mothers, milk, pups. As the possible consequences for mothers offspring smoking are still unknown, evaluated effects on nutritional, biochemical, hormonal parameters dams pups at weaning. After 72 h from birth, lactating rats were...