A5019792424- Renaissance and Early Modern Studies
- Mental Health and Psychiatry
- Bone Metabolism and Diseases
- Psychosomatic Disorders and Their Treatments
- Mental Health Treatment and Access
- Bone health and treatments
- Metabolism, Diabetes, and Cancer
- Inflammatory mediators and NSAID effects
- Historical and Religious Studies of Rome
- Bone health and osteoporosis research
- Schizophrenia research and treatment
- Hormonal Regulation and Hypertension
- Historical Art and Architecture Studies
- Thyroid and Parathyroid Surgery
- Diabetes Treatment and Management
- Health and Well-being Studies
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Hip and Femur Fractures
- Healthcare professionals’ stress and burnout
- Adrenal and Paraganglionic Tumors
- Body Image and Dysmorphia Studies
- Italian Literature and Culture
- Health, psychology, and well-being
- Growth Hormone and Insulin-like Growth Factors
Odense University Hospital
2017-2024
University of Southern Denmark
2021-2024
University of Birmingham
2022-2023
Endokrinologikum
2019
Kolding Hospital
2016-2018
National Gallery of Art
2016
Odense Municipality
2016
Stanford University
2009-2014
Vejle Sygehus
2001-2005
Aarhus University Hospital
2001-2005
Abstract Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized by increased bone resorption inadequate formation. As novel antiosteoporotic therapeutics are needed, understanding genetic regulation human could help identify potential treatment targets. This study aimed provide an overview transcriptional reprogramming during differentiation. Osteoclasts were differentiated from CD14 + monocytes eight female donors. RNA...
BackgroundPrevious studies have indicated that glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) may enhance bone formation and neutral or beneficial effects on fracture risk. We evaluated the effect of GLP-1RA semaglutide marker Procollagen type I N-terminal propeptide (PINP) in adults with increased risk.MethodsThis randomised, placebo-controlled, double-blinded, phase 2 clinical trial was conducted at two public hospitals Denmark. enrolled 64 men women risk based a T-score <...
Objective: Physical complaints not attributable to verifiable, conventionally defined diseases, i.e., medically unexplained or functional somatic symptoms, are prevalent in all medical settings, but their classification is contested as numerous overlapping diagnoses and syndrome labels have been introduced. This study aims determine whether symptoms cluster into distinct syndromes diagnostic entities. Methods: The 978 consecutively admitted patients from a neurological department (n = 120),...
Abstract Objective Drugs targeting the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) are emerging as treatments for type-2 diabetes and obesity. GIP acutely decreases serum markers of bone resorption transiently increases formation in short-term clinical investigations. However, it is unknown whether acts directly on cells to mediate these effects. Using a GIPR-specific antagonist, we aimed assess primary human osteoclasts osteoblasts. Methods Osteoclasts were...
Osteoporosis results from disturbances in bone formation and resorption. Recent nonhuman data suggest that the reproductive hormone kisspeptin directly stimulates osteoblast differentiation vitro thus could have clinical therapeutic potential. However, effects of on human metabolism are currently unknown.To assess vivo.In study: Mono- cocultures osteoblasts osteoclasts treated with kisspeptin. Clinical Randomized, placebo-controlled, double-blind, 2-way crossover study 26 men investigating...
Obesity adversely affects bone and fat metabolism in mice humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose homeostasis obesity. However, the impact of omega-3 PUFAs on marrow adipose tissue (BMAT) stromal cell (BMSC) has not intensively studied yet. In present study we demonstrated that PUFA supplementation high diet (HFD + F) improved parameters, mechanical properties along with decreased BMAT obese when compared HFD group. Primary BMSCs...
ABSTRACT Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes turnover after meal intake GIP- GLP-2 injections, respectively, mediated via PTH secretion. This tested female patients with hypoparathyroidism given standardized liquid mixed-meal test...
Introduction Injection of paraffin oil to augment muscles size is a troubling phenomenon known cause foreign body reaction with formation granulomas. In few case reports, long-term side effects have been reported in terms hypercalcemia and renal failure. Methods We identified series 12 male bodybuilders presenting non-parathyroid who previously had injected increase size. Results At admission, all patients moderate-to-severe suppressed PTH levels impaired function. Calcitriol were within the...
Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions on bone this context complex. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a mediator therapeutic vivo. In study we delineate role 11β-HSD1 effects GC during polyarthritis. Its function was assessed biopsies from patients with RA and osteoarthritis, primary osteoblasts osteoclasts. Bone...
Objective The primary objective of this study was to investigate if among medical inpatients their health service use associated with 1) presence and type mental disorders, 2) emotional distress somatization, 3) self-rated physical disability health. Method Health (number admissions nonpsychiatric departments reimbursement care services) as well psychological (SCL-8D) somatization (Whiteley-7) assessed for 294 consecutive inpatients. Patients rated own functioning, consultants them chronic...
Legalized use of cannabis for medical or recreational is becoming more and common. With respect to potential side-effects on bone health only few clinical trials have been conducted - with opposing results. Therefore, it seems that there a need knowledge the effects cannabinoids human cells. We studied effect cannabidiol (CBD) Δ9-tetrahydrocannabinol (THC) (dose range from 0.3 30 μM) osteoclasts in mono- as well co-cultures osteoblast lineage used CD14
Abstract In early eighteenth-century Naples, Paolo De Matteis created a series of frescoes featuring the Trinity in imitation mural at Escorial by his former teacher, Luca Giordano. By showing with its patrilinear procession from Father to Son, younger artist could claim an artistic lineage competition Francesco Solimena. Matteis’s and Solimena’s Trinitarian murals reveal theological disagreements between religious orders Naples. An unknown drawing Seattle Art Museum can be associated group works.