A5071287733- Electrolyte and hormonal disorders
- Diabetes Treatment and Management
- Renal function and acid-base balance
- Ion Transport and Channel Regulation
- Blood Pressure and Hypertension Studies
- MRI in cancer diagnosis
- Acute Kidney Injury Research
- Vitamin D Research Studies
- Nitric Oxide and Endothelin Effects
- Hemodynamic Monitoring and Therapy
- Sodium Intake and Health
- Diabetes Management and Research
- Genetic and Kidney Cyst Diseases
- Hormonal Regulation and Hypertension
- Potassium and Related Disorders
- Apelin-related biomedical research
- Parathyroid Disorders and Treatments
- Organ Donation and Transplantation
- Cardiovascular Health and Disease Prevention
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Thermoregulation and physiological responses
- Bone health and osteoporosis research
- Hydrogen's biological and therapeutic effects
- Healthcare cost, quality, practices
Glostrup Hospital
2021-2025
Aarhus University
2015-2025
Aarhus University Hospital
2014-2024
Regionshospitalet Herning
2024
Regional Hospital West Jutland
2016-2022
Danish Society of Nephrology
2022
Regional Hospital Holstebro
2012-2020
Low 25-hydroxy-vitamin D (25(OH)D) levels are inversely related to blood pressure (BP) and have been associated with incident hypertension. In people living at northern latitudes diminished cholecalciferol synthesis in the winter increases risk of vitamin deficiency. We wanted test hypothesis that daily supplementation lowers BP patients hypertension.We investigated effect 75 µg (3,000 IU) per day a randomized, placebo-controlled, double-blind study 130 hypertensive residing Denmark (56º N)....
Patients on chronic dialysis are at increased risk of vitamin D deficiency. In observational studies plasma 25-hydroxyvitamin (p-25(OH) D) levels inversely correlated with BNP and adverse cardiovascular outcomes. Whether a causal relation exists has yet to be established. The aim this study was test the hypothesis that cholecalciferol supplementation improves cardiac function reduces blood pressure (BP) pulse wave velocity (PWV) in patients dialysis. randomized, placebo-controlled,...
Background Sodium-glucose-cotransporter 2 inhibitors (SGLT2is) have revolutionized the treatment of type diabetes mellitus (DM2) and chronic kidney disease (CKD), reducing risk cardiovascular renal end points by up to 40%. The underlying mechanisms are not fully understood. Objective study aims examine effects empagliflozin versus placebo on hemodynamics, sodium balance, vascular function, markers innate immune system in patients with DM2, DM2 CKD, nondiabetic CKD. Methods We conducted 3...
Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (82Rb) positron emission tomography/computed tomography (PET/CT) perfusion determination found strong indications method precision reliability. The aim this study was compare 82Rb clearance with technetium-99m-mercaptoacetyltriglycine ([99mTc]Tc-MAG3) as a first...
Background: Sodium glucose cotransporter 2 inhibitors lower blood pressure. The underlying mechanisms are multifactorial and include effects on vascular function. We examined the systemic hemodynamic of empagliflozin in patients with type diabetes mellitus (DM2) without chronic kidney disease (CKD) nondiabetic CKD. Methods: Three double-blinded, randomized, placebo-controlled cross-over trials, including DM2 preserved renal function ( n = 16), CKD 17) 16). Participants were randomized to 4...
Vitamin D receptor activators reduce albuminuria, and may improve survival in chronic kidney disease (CKD). Animal studies suggest that these pleiotropic effects of vitamin be mediated by suppression renin. However, randomized trials humans have yet to establish this relationship.In a randomized, placebo-controlled, double-blinded crossover study, the effect oral paricalcitol (2 μg/day) was investigated 26 patients with non-diabetic, albuminuric stage III-IV CKD. After treatment, plasma...
Sodium nitrite (NaNO 2 ) is converted to nitric oxide (NO) in vivo and has vasodilatory natriuretic effects. Our aim was examine the effects of NaNO on hemodynamics, sodium excretion, glomerular filtration rate (GFR). In a single-blinded, placebo-controlled, crossover study, we infused placebo (0.9% NaCl) or 0.58, 1.74, 3.48 μmol ·kg −1 ·h for h 12 healthy subjects, after 4 days standard diet. Subjects were supine water loaded. We measured brachial central blood pressure (BP), plasma...
The renal distal nephron plays an important role in the maintenance of sodium balance, extra cellular volume and blood pressure. degree water transport, via aquaporin2 channels (AQP2), epithelial (ENaC) collecting duct principal cells are reflected by level urinary excretion AQP2 (u-AQP2) γ-fraction ENaC (u-ENaCγ). effects acute intravenous load with isotonic saline, hypertonic saline glucose on u-AQP2, u-ENaCγ underlying mechanisms have never been studied a randomized, placebo-controlled...
Introduction Injection of paraffin oil to augment muscles size is a troubling phenomenon known cause foreign body reaction with formation granulomas. In few case reports, long-term side effects have been reported in terms hypercalcemia and renal failure. Methods We identified series 12 male bodybuilders presenting non-parathyroid who previously had injected increase size. Results At admission, all patients moderate-to-severe suppressed PTH levels impaired function. Calcitriol were within the...
Background Hypertension is the leading risk factor for cardiovascular disease worldwide. Patients with blood pressure (BP) response to dietary sodium reduction are referred as “salt sensitive.” Salt sensitivity (SS) might be due differences in storage capacity and erythrocyte SS examines this of red cells. This study aimed test effect a self‐performed reduced diet on BP patients essential hypertension examine whether predicts SS. Methods Results Seventy‐two were included randomized 2:1...
Renal handling of sodium and water is abnormal in chronic kidney disease (CKD). The aim this study was to test the hypothesis that activity aquaporin-2 channels (AQP2), sodium-potassium-2chloride transporter (NKCC2) and/or epithelial (ENaC) contribute phenomenon. 23 patients with CKD 24 healthy controls at baseline after 3% saline infusion were compared. following measurements performed: urinary concentrations AQP2 (u-AQP2), NKCC2 (u-NKCC2), ENaC (u-ENaCγ), glomerular filtration rate (GFR)...
<b><i>Introduction:</i></b> Invasive bone biopsy to assess metabolism in patients with chronic kidney disease-mineral and disorder may be replaced by the noninvasive <sup>18</sup>F-NaF PET/CT biomarkers of metabolism. We aimed compare parameters turnover, mineralization, volume assessed biopsies results derived from (bone-specific alkaline phosphatase, osteocalcin, fibroblast growth factor 23, osteoprotegerin)....
Nitric oxide (NO) is a ubiquitous vasodilator and an important regulator of renal sodium excretion. To further investigate the role NO in handling, we studied effects synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA), crossover dose–response study. During inhibition mean arterial pressure increased dose-dependently reached plateau after 20 minutes infusion. On contrary, fractional excretion was reduced equally all three L-NMMA doses. This indicates that highly sensitive to even small...
Chloride is speculated to have nephrotoxic properties. In healthy subjects we tested the hypothesis that acute chloride loading with 3% saline would induce kidney injury, which could be prevented loop-diuretic furosemide. The study was designed as a randomized, placebo-controlled, crossover study. Subjects were given accompanied by either placebo or Before, during and after infusion of measured glomerular filtration rate (GFR), fractional excretion sodium (FENa), urinary (u-Cl), excretions...
Abstract Background Changes in renal blood flow (RBF) may play a pathophysiological role hypertension and kidney disease. However, RBF determination humans has proven difficult. We aimed to confirm the feasibility of estimation based on positron emission tomography/computed tomography (PET/CT) rubidium-82 ( 82 Rb) using abdominal aorta as input function 1-tissue compartment model. Methods Eighteen healthy subjects underwent two dynamic Rb PET/CT scans different fields view (FOV). FOV-A...
Abstract Background Changes in renal perfusion may play a pathophysiological role hypertension and kidney disease, however to date, no method for blood flow (RBF) determination humans has been implemented clinical practice. In previous study, we demonstrated that estimation of based on single positron emission tomography/computed tomography (PET/CT) scan with Rubidium-82 ( 82 Rb) is feasible found an approximate 5% intra-assay coefficient variation both kidneys, indicative precise...
Abstract Background Acute interstitial nephritis (AIN) is an important and common cause of acute renal failure. There are no generally accepted guidelines for the treatment AIN, due to lack prospective randomized trials. Since AIN characterized by enhanced immune response, immunosuppressive could potentially improve prognosis attenuating inflammation subsequent fibrosis. Despite limited evidence effects steroids potential adverse effects, prednisolone frequently used in there a strong need...
The increasing incidence of chronic kidney disease (CKD) is straining the capacity outpatient clinics. Remote healthcare delivery might improve CKD follow-up compared with conventional face-to-face follow-up. Patient-reported outcomes (PROs) are used to empower remote and patient engagement. consequences shifting from on function, health resource utilisation quality life remain unknown.
ABSTRACT Background This study validates the application of Systematized Nomenclature Medicine second edition (SNOMED II) codes used to describe medical kidney biopsies in Denmark encoded form, aiming support robust epidemiological research on causes, treatments and prognosis diseases. Methods Kidney biopsy reports from 1 January 1998 31 December 2018 were randomly extracted Danish National Patobank, using SNOMED codes. A 5% sample was selected, nephrologists assessed corresponding records,...
Abstract Aims The objective of this study was to examine the effects empagliflozin on endothelium‐dependent and endothelium‐independent vasodilatation systemic hemodynamic parameters assess role nitric oxide (NO) system in patients with type 2 diabetes (T2DM). Materials Methods In double‐blind, placebo‐controlled cross over trial, T2DM were treated either 10 mg or matching placebo for 4 weeks. Following a 2‐week washout, participants crossed weeks opposite treatment. Forearm blood flow (FBF)...
Aims Clinical trials suggest that statins have beneficial effects on the cardiovascular system independent from their cholesterol lowering properties. In patients with chronic kidney disease stage II–III , we tested hypothesis atorvastatin increased systemic and renal nitric oxide ( NO ) availability using L ‐ N G ‐monomethyl arginine NMMA as an inhibitor of production. Methods a randomized, placebo‐controlled, crossover study were treated for 5 days standardized diet fluid intake....
Background: Statins have beneficial effects on cardiovascular morbidity and mortality independently of reduction plasma cholesterol. Purpose methods: In patients with type 2 diabetes nephropathy, chronic kidney disease stage II-III, we tested the hypothesis that atorvastatin increased systemic renal nitric oxide (NO) availability using L-NMMA as an inhibitor NO production. We performed a randomized, placebo-controlled, crossover study, atorvastatin/placebo treatment for five days...
Tolvaptan is a selective vasopressin receptor antagonist (V2R) that increases free water excretion. We wanted to test the hypotheses tolvaptan changes both renal handling of and sodium systemic hemodynamics during basal conditions nitric oxide (NO)-inhibition with L-NG-monomethyl-arginine (L-NMMA).Nineteen healthy subjects were enrolled in randomized, placebo-controlled, double-blind, crossover study two examination days. 15 mg or placebo was given morning. L-NMMA as bolus followed by...