A5091200840- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Polysaccharides Composition and Applications
- biodegradable polymer synthesis and properties
- Liver physiology and pathology
- Hydrogels: synthesis, properties, applications
- Advanced Cellulose Research Studies
- Rheology and Fluid Dynamics Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mathematical Biology Tumor Growth
- Neuroscience and Neural Engineering
- Natural Fiber Reinforced Composites
- Enzyme Catalysis and Immobilization
- Material Properties and Processing
- Tissue Engineering and Regenerative Medicine
- Pancreatic function and diabetes
- Electrostatics and Colloid Interactions
- Brain Metastases and Treatment
- Metabolomics and Mass Spectrometry Studies
- Lignin and Wood Chemistry
- Muscle Physiology and Disorders
- Polysaccharides and Plant Cell Walls
- Surfactants and Colloidal Systems
- Layered Double Hydroxides Synthesis and Applications
- Plant Surface Properties and Treatments
HRA Pharma (France)
2023
Bioengineering Center
2017
John Wiley & Sons (United States)
2017
National Center for Genetic Engineering and Biotechnology
2017
Normandie Université
2015
Université de Rouen Normandie
2007-2015
Centre National de la Recherche Scientifique
2007-2015
Polymères, Biopolymères, Surfaces
2007-2015
Différenciation et Communication Neuronale et Neuroendocrine
2015
University of Monastir
2007-2009
The Ca–Al‐layered double hydroxide, the so‐called AFm phase, is a product of cement hydration. It shown that interaction this phase with anionic polycarboxylate ether (PCE)‐based dispersant polymers not simple adsorption but more complex intercalation phenomenon leading to transient sequestration PCE within crystallites. As result, part immobilized, forming layered organo‐mineral composite, and does play its role dispersing agent. This article presents, along general considerations on links...
Hydrophobic octyl moieties have been grafted in various densities onto the carboxylic acid functions of xanthan under its ordered conformation. The outcoming amphiphilic and associative properties were studied by fluorescence spectroscopy rheology. Results showed that conformation is not affected chemical modification remains same as native one. Additionally, derivatives do show any viscoelastic enhancement; nevertheless, their dynamics strongly slowed down: higher grafting density, slower...
Abstract The liver plays a key role in the metabolism of lipoproteins, controlling both production and catabolism. To accelerate development new lipid‐lowering therapies humans, it is essential to have relevant vitro study model available. current hepatocyte‐like cells (HLCs) models derived from hiPSC can be used many genetically driven diseases but require further improvement better recapitulate complexity functions. Here, we aimed improve maturation HLCs using three‐dimensional (3D)...
AMDES (aminopropylmethyldiethoxysilane) was used to investigate the physicochemical and chemical events related introduction of aminoalkylalkoxysilanes in cellulosic materials. Using (29)Si CP-MAS (1)H NMR study reactivity structural modification paper it shown that polymerization occurs situ. The distribution active compound on surface fibers throughout fibers' thickness visualized by SEM-EDS. A relation between moisture content, fiber swelling, uptake found. To better represent old brittle...
The 3Rs guidelines recommend replacing animal testing with alternative models. One of the solutions proposed is organ-on-chip technology in which liver-on-chip one most promising alternatives for drug screening and toxicological assays. main challenge to achieve relevant vivo-like functionalities liver tissue an optimized cellular microenvironment. Here, we investigated development hepatic cells under dynamic conditions inside a 3D hydroscaffold embedded microfluidic device. made hyaluronic...
The physicochemical modifications in papers upon introducing AEAPMDMS (3 N-(2-aminoethyl)-3-aminopropylmethyl-dimethoxysilane) as a dry strength and deacidification agent were explored. double amine functionality was shown to favor penetration the cellulose fibers, with large uptakes being achieved at low concentration. In situ polymerization paper demonstrated using 29Si CP-MAS 1H NMR. distribution of compound inside on fibers' surface evidenced SEM-EDS XPS. efficacy established....
The lack of relevant in vitro models for adipose tissue makes necessary the development a more physiological environment providing spatial and chemical cues effective maturation adipocytes. We developed biofunctionalized hydrogel with components extracellular matrix: collagen I, VI, cell binding domain fibronectin we compared it to usual 2D cultures on plastic plates. This scaffold allowed 3D culture mature adipocytes from preadipocytes lines 3T3-L1 3T3-F442A, as well primary Human White...
Brown lines were generated at the wet-dry interface on Whatman paper No. 1 by suspending sheet vertically in deionized water. Formic acid and acetic quantified three areas of defined boundary (above, below, tideline) using capillary zone electrophoresis with indirect UV detection. Their concentration increased upon accelerated aging was highest tideline. The hydroperoxides have been reverse phase high performance liquid chromatography detection based determination triphenylphosphine oxide...
Abstract Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition reducing survival. The development metastases harmful triple-negative breast cancer (TNBC). To date, mechanisms that induce TNBC are poorly understood. Methods Using human blood–brain barrier (BBB) vitro model, an 3D organotypic extracellular matrix, ex vivo mouse slices co-culture xenograft experiment,...
ABSTRACT Polymers consisting of poly(acrylic acid) (PAA) and statistical poly[(acrylic acid)‐ co ‐( tert ‐butylacrylate)] (P(AA‐ ‐ t BA)), attached to both extremities Jeffamine® (D series based on a poly(propylene oxide) (PPO) with one amine function at each end) using atom transfer radical polymerization (ATRP) are presented in this article. An original bifunctional amide‐based macroinitiator was first elaborated from Jeffamine®. BA subsequently initiated macroinitiator. This occurs...
Polysaccharides have attractive advantages for using in the field of pharmaceutics. In most cases, they are non toxic, biocompatible and plentiful. The presence hydroxyl groups (always) carboxylic acid (sometimes) permits crosslinking chains obtaining hydrogels. These hydrogels present interesting swelling mechanical properties. They capacity to entrap active compounds such as drugs release them through modifications solvation conditions vias pH or ionic strength changes. This review deals...
Pharmacological evaluation of anticancer drugs using 3D in vitro models provides invaluable information for predicting vivo activity. Artificial matrices are currently available that scale up and increase the power such models. The aim present study was to propose an efficient robust imaging analysis pipeline assess with quantitative parameters efficacy a particular cytotoxic drug. HCT116 colorectal adenocarcinoma tumor cell multispheres were grown physiological hyaluronic acid matrix....
The liver is one of the main organs involved in metabolism xenobiotics and a key organ toxicity studies. Prior to accessing hepatocytes, pass through hepatic sinusoid formed by sinusoidal endothelial cells (LSECs). LSECs barrier regulates kinetics concentrations before their metabolic processing hepatocytes. To mimic this physiological situation, we developed an vitro model reproducing coculture with hepatocyte biochip, using fluidic platform. This technology made dynamic tissue crosstalk...
Pancreatic cancer (PC) is a deadly for which no diagnostic or prevention plan currently exists since this asymptomatic in its early development. The very specific and complex tumor microenvironment of PC responsible the unsuccessful delivery therapeutics molecules to cells. For high throughput testing new molecules, there crucial need more accurate preclinical model. first time, we integrated microfluidic system 5 major features microenvironment: i) type-I collagen (CI), ii) hyaluronic acid...
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Abstract Monitoring drug activity in multicellular tumor spheroid vitro models is an important challenge as these 3D have demonstrated their major relevance pharmacological screening and anticancer drugs evaluation (1). Optical microscopy coupled to the selective plane illumination (SPIM)3D microscopy, and, automatic automated images processing quantitative analysis are promising approaches process optimizes of response a cell culture with, high/mediumhigh throughput waycapabilities....