A5020520466- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Renal cell carcinoma treatment
- CAR-T cell therapy research
- Colorectal and Anal Carcinomas
- Multiple Myeloma Research and Treatments
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- CRISPR and Genetic Engineering
- Esophageal and GI Pathology
- BRCA gene mutations in cancer
Chica and Heinz Schaller Foundation
2023-2025
Heidelberg University
2023-2025
Centre National de la Recherche Scientifique
2014-2024
Centre d'Immunophénomique
2014-2024
Inserm
2014-2024
Université de Rouen Normandie
2015-2024
Centre Hospitalier Universitaire de Rouen
2011-2024
Centre Henri Becquerel
2012-2024
Hôpital Charles-Nicolle
2009-2024
Normandie Université
2019-2024
The predictive value of KRAS mutation in metastatic colorectal cancer (MCRC) patients treated with cetuximab plus chemotherapy has recently been suggested. In our study, 59 a chemotherapy-refractory MCRC were included and clinical response was evaluated according to evaluation criteria solid tumours (RECIST). Tumours screened for mutations using first direct sequencing, then two sensitive methods based on SNaPshot PCR-ligase chain reaction (LCR) assays. Clinical gene the Fisher exact test....
Alessia Montagnoli, Francesca Fiore, Esther Eytan, Andrea C. Carrano, Giulio F. Draetta, Avram Hershko, and Michele Pagano Department of Pathology Kaplan Comprehensive Cancer Center, New York University Medical York, 10016 USA; European Institute Oncology, 20141 Milan, Italy; Technion–Israel Technology, Haifa 31096, Israel
Purpose The antiepidermal growth factor receptor antibody cetuximab shows activity in irinotecan-refractory metastatic colorectal cancer (mCRC), mainly wild-type KRAS tumors. Cetuximab may also exert antitumor effects through antibody-dependent cell-mediated cytotoxicity (ADCC) which Fc portion interacts with receptors (FcγRs) expressed by immune cells. ADCC is influenced FcγRIIa-H131R and FcγRIIIa-V158F polymorphisms that are clinically relevant follicular lymphoma breast treated rituximab...
Early results at 3 years from the PRODIGE 24/Canadian Cancer Trials Group PA6 randomized clinical trial showed survival benefits with adjuvant treatment modified FOLFIRINOX vs gemcitabine in patients resected pancreatic ductal adenocarcinoma; mature data are now available.To report 5-year outcomes and explore prognostic factors for overall survival.This open-label, phase was conducted 77 hospitals France Canada included aged 18 to 79 histologically confirmed adenocarcinoma who had undergone...
T cells that recognize tumor antigens are crucial for mounting antitumor immune responses. Induction of in immunogenic tumors depends on STING, the intracellular innate receptor cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) and related dinucleotides (CDNs). However, optimal way to leverage STING activation nonimmunogenic is still unclear. Here, we show cGAMP delivery by intratumoral injection virus-like particles (cGAMP-VLP) led differentiation circulating tumor-specific...
Here we describe a new mouse model that exploits the pattern of expression high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)-mediated ablation tissue-resident macrophages monocyte-derived cells. We found myeloid cells ear skin dermis are dominated by DT-sensitive, melanin-laden have been missed in previous studies correspond to ingested melanosomes from neighboring melanocytes. Those referred as melanophages humans. also identified melanocytic melanoma. Benefiting our...
Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition dynamics PD-1 BTLA signalosomes in primary effector T cells at cell-antigen-presenting cell interface. We also solve existing controversy regarding role SHP-1 SHP-2 protein-tyrosine phosphatases mediating coinhibition. predominantly recruits SHP-2, but when absent, it remains functional. In contrast, to a lesser extent SHP-2....
Controlling the overwhelming inflammatory reaction associated with polymicrobial sepsis remains a prevalent clinical challenge few treatment options. In septic peritonitis, blood neutrophils and monocytes are rapidly recruited into peritoneal cavity to control infection, but role of resident sentinel cells during early phase infection is less clear. particular, influence mast on other tissue-resident poorly understood. Here, we developed mouse model that allows both visualization conditional...
The direct comparison of CA19.9, circulating tumour cells (CTCs) and DNA (ctDNA) using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has never been performed for the diagnosis solid pancreatic tumours (SPTs).We included 68 patients with a SPT referred EUS-FNA. CTCs were analysed size-based platform ctDNA digital PCR. sensitivity, specificity, negative positive predictive values evaluated each marker their combination.SPTs corresponded to 58 malignant (52 adenocarcinoma (PA) 6...
// Florian Clatot 1,2,3 , Anne Perdrix 3,4 Laetitia Augusto 1 Ludivine Beaussire 3,5 Julien Delacour Céline Calbrix 4 David Sefrioui 3,5,6 Pierre-Julien Viailly 2 Michael Bubenheim 7 Cristian Moldovan Cristina Alexandru Isabelle Tennevet Olivier Rigal Cécile Guillemet Marianne Leheurteur Sophie Gouérant Camille Petrau 1,3 Jean-Christophe Théry 1,5 Jean-Michel Picquenot 1,2,4 Corinne Veyret Thierry Frébourg 5 Fabrice Jardin Nasrin Sarafan-Vasseur 3,5,* and Frédéric Di Fiore 1,3,5,6,*...
Acquired estrogen receptor gene (ESR1) mutations have been recently reported as a marker of resistance to aromatase inhibitors in hormone positive metastatic breast cancer. We retrospectively considered seven patients treated for cancer with available samples from the primary tumor before any treatment, cryopreserved metastasis removed during progression and concomitant plasmas. All these were disease after previous exposure at least 6 months, assessed ESR1 detection circulating DNA. For...
The RLTPR cytosolic protein, also known as CARMIL2, is essential for CD28 co-stimulation in mice, but its importance human T cells and mode of action remain elusive. Here, using affinity purification followed by mass spectrometry analysis, we showed that acts a scaffold, bridging to the CARD11/CARMA1 adaptor NF-κB signaling pathway, identified proteins not found before within pathway. We further demonstrated noncanonical pleckstrin-homology domain, leucine-rich repeat proline-rich region...
Conventional dendritic cells expressing the XCR1 chemokine receptor (cDC1s) excel at cross-presentation. Here, we developed and used a mouse model in which Cre recombinase is expressed under control of Xcr1 gene while preserving expression. We it to generate mice with conditional deletion MHC class II (MHCII) molecules on cDC1s. By preventing cDC1s receive suppressive regulatory T cell inputs via MHCII-restricted interactions, objective present study was gauge whether MHCII-deficient lose...
Abstract Lung diseases develop when telomeres shorten beyond a critical point. We constructed mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive form (mTert CI ), is expressed from p21 Cdkn1a locus. Expression either TERT reduces global levels lungs aged mice, highlighting non-canonical function. However, only accumulation very short telomeres, oxidative damage, endothelial cell (ECs) senescence and senile emphysema mice. Single-cell analysis lung...
To assess epidemiologic features and predictive factors of mortality acute upper gastrointestinal bleeding (UGIB).During a 6-month period, prospective population-based study including all the UGIB occurring in geographic area 3 million people was conducted. Data from cirrhotic patients were compared with those noncirrhotic patients.A total 2,133 recorded, 21.9% (n = 468). Endoscopic hemostasis performed 46.5% 8.3% patients, respectively (P < 0.001). Mortality during hospitalization 23.5%...
Background: Limited evidence exists on the impact of adding a taxane, using endocrine therapy and carrying deleterious germline BRCA mutation ovarian reserve measured by anti-müllerian hormone (AMH) levels young breast cancer patients receiving (neo)adjuvant cyclophosphamide- anthracycline-based chemotherapy. Methods: This is biomarker analysis including (≤ 40 years) early with known mutational status available prospectively collected frozen plasma samples before after Chemotherapy consisted...