A5027344903- MicroRNA in disease regulation
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Gene expression and cancer classification
- Advanced Nanomaterials in Catalysis
- Microbial Community Ecology and Physiology
- Immune cells in cancer
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Bayesian Modeling and Causal Inference
- Mosquito-borne diseases and control
Helmholtz Institute for Pharmaceutical Research Saarland
2022-2024
Helmholtz Centre for Infection Research
2022-2024
Saarland University
2019-2024
Myelination of neuronal axons is essential for nervous system development. requires dramatic cytoskeletal dynamics in oligodendrocytes, but how actin regulated during myelination poorly understood. We recently identified serum response factor (SRF)—a transcription known to regulate expression and regulators other cell types—as a critical driver the aged brain. Yet, major gap remains understanding mechanistic role SRF oligodendrocyte lineage cells. Here, we show that required autonomously...
Abstract Arm selection, the preferential expression of a 3′ or 5′ mature microRNA (miRNA), is highly dynamic and tissue-specific process. Time-dependent shifts switches between arms are also relevant for human diseases. We present miRSwitch, web server to facilitate analysis interpretation arm selection events. Our species-independent tool evaluates pre-processed small non-coding RNA sequencing (sncRNA-seq) data, i.e. matrices output files from miRNA quantification tools (miRDeep2,...
In many research disciplines, ordered lists are compared. One example is to compare a subset of all significant genes or proteins in primary study those replication study. Often, the top compared using Venn diagrams, ore more precisely Euler diagrams (set showing logical relations between finite collection different sets). If cohort sizes, techniques algorithms for evaluation were applied, direct comparison with fixed threshold can however be misleading and approaches comparing would...
Despite recent methodology and reference database improvements for taxonomic profiling tools, metagenomic assembly genomic binning remain important pillars of analysis workflows. In case information is lacking, considered to be a state-of-the-art method in mixed culture data analysis. this light, our previously published tool BusyBee Web implements composition-based efficient enough function as rapid online utility. Handling assembled contigs long nanopore generated reads alike, the...
Abstract The molecular causes and mechanisms of neurodegenerative diseases remain poorly understood. A growing number single-cell studies have implicated various neural, glial, immune cell subtypes to affect the mammalian central nervous system in many age-related disorders. Integrating this body transcriptomic evidence into a comprehensive reproducible framework poses several computational challenges. Here, we introduce ZEBRA, large single-nucleus RNA-seq database. ZEBRA integrates...
Abstract Aging is a multifactorial and complex physiological process, affecting every organ with characteristic manifestations. Understanding the molecular mechanisms that drive aging processes crucial to targeting age-related disorders. Recent reports suggest severe post-infection syndromes can partially accelerate aging. However, underlying gene-encoded regulatory interplay, whether being shared or distinct between infection biology are poorly understood. Here, we employed spatial...
ABSTRACT Myelination of neuronal axons is essential for nervous system development. requires dramatic cytoskeletal dynamics in oligodendrocytes, but how actin regulated during myelination poorly understood. We recently identified serum response factor (SRF)—a transcription known to regulate expression and regulators other cell types—as a critical driver the aged brain. Yet, major gap remains understanding fundamental role SRF oligodendrocyte lineage cells. Here we show that required...
Abstract Arm selection, the preferential expression of a 3′ or 5′ mature microRNA (miRNA), is highly dynamic and tissue-specific process. Time-dependent shifts switches between arms are also relevant for human diseases. We present miRSwitch, web server to facilitate analysis interpretation arm selection events. Our species-independent tool evaluates pre-processed small non-coding RNA sequencing (sncRNA-seq) data, i.e. matrices output files from miRNA quantification tools (miRDeep2,...