A5013773391- Microbial Natural Products and Biosynthesis
- Pineapple and bromelain studies
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Biochemical and Structural Characterization
- Microbial Metabolism and Applications
- Cancer therapeutics and mechanisms
- Glycosylation and Glycoproteins Research
- Bacteriophages and microbial interactions
- Microbial Community Ecology and Physiology
- Synthetic Organic Chemistry Methods
- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Bacterial Genetics and Biotechnology
- Oxidative Organic Chemistry Reactions
- Calcium signaling and nucleotide metabolism
- Natural product bioactivities and synthesis
- Escherichia coli research studies
- Marine Sponges and Natural Products
- Gene expression and cancer classification
Helmholtz Institute for Pharmaceutical Research Saarland
2020-2024
German Center for Infection Research
2020-2024
Helmholtz Centre for Infection Research
2020-2022
Saarland University
2020-2022
Cittilins are secondary metabolites from myxobacteria comprised of three l-tyrosines and one l-isoleucine forming a bicyclic tetrapeptide scaffold with biaryl aryl-oxygen-aryl ether bonds. Here we reveal that cittilins belong to the ribosomally synthesized post-translationally modified peptide (RiPP) family natural products, for which only crocagins have been reported myxobacteria. A 27 amino acid precursor harbors C-terminal four core peptide, is enzymatically finally exported yield...
Despite recent methodology and reference database improvements for taxonomic profiling tools, metagenomic assembly genomic binning remain important pillars of analysis workflows. In case information is lacking, considered to be a state-of-the-art method in mixed culture data analysis. this light, our previously published tool BusyBee Web implements composition-based efficient enough function as rapid online utility. Handling assembled contigs long nanopore generated reads alike, the...
High-quality DNA extraction is a crucial step in metagenomic studies. Bias by different isolation kits impairs the comparison across datasets. A trending topic is, however, analysis of multiple metagenomes from same patients to draw holistic picture microbiota associated with diseases. We thus collected bile, stool, saliva, plaque, sputum, and conjunctival swab samples performed three commercial kits. For each combination specimen type kit, 20-gigabase (Gb) data were generated using...
Antimicrobial resistance is one of the major health threats modern world. Thus, new structural classes antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids represent such compound class that inhibit well-established target bacterial type II topoisomerases while exhibiting superior antibacterial and resistance-breaking properties. Understanding potential mechanisms emerging resistances crucial development novel antibiotics as they directly impact future...
Abstract Antimicrobial resistance is one of the major health threats modern world. Thus, new structural classes antimicrobial compounds are needed in order to overcome existing resistance. Cystobactamids as such a compound class inhibit well-established target bacterial type II topoisomerases while exhibiting superior antibacterial and resistance-breaking properties. Understanding potential mechanisms emerging resistances crucial development novel antibiotics they directly impact future...
Abstract The highly glycosylated spike protein of SARS‐CoV‐2 is essential for infection and constitutes a prime target antiviral agents vaccines. pineapple‐derived jacalin‐related lectin AcmJRL present in the medication bromelain significant quantities has previously been described to bind mannosides. Here, we performed large ligand screening by glycan array analysis, quantified interaction with carbohydrates validated high‐mannose glycans as preferred ligands. Because was reported carry...
Myxoprincomide, a secondary metabolite of the myxobacterium Myxococcus xanthus DK 1622, is synthesised for first time. The unusual α-ketoamide formed at end synthesis.
Abstract Cittilins are secondary metabolites from myxobacteria comprised of three L-tyrosines and one L-isoleucine forming a bicyclic tetrapeptide scaffold with biaryl aryl-oxygen-aryl ether bonds. Here we reveal that cittilins belong to the ribosomally synthesized post-translationally modified peptide (RiPP) family natural products, for which only crocagins have been reported myxobacteria. A 27 amino acid precursor harbors C -terminal four core peptide, is enzymatically finally exported...
Abstract The current SARS-CoV-2 pandemic has become one of the most challenging global health threats, with over 530 million reported infections by May 2022. In addition to vaccines, research and development have also been directed towards novel drugs. Since highly glycosylated spike protein is essential for infection, it constitutes a prime target antiviral agents. pineapple-derived jacalin-related lectin (AcmJRL) present in medication bromelain significant quantities previously described...