A5002906019- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Conditions and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Cardiomyopathy and Myosin Studies
- Cardiac and Coronary Surgery Techniques
- Congenital Diaphragmatic Hernia Studies
- Coronary Artery Anomalies
- Vascular Anomalies and Treatments
- Vasculitis and related conditions
- Viral Infections and Immunology Research
Heart and Diabetes Center North Rhine-Westphalia
2016-2025
Ruhr University Bochum
2013-2023
University of Minnesota
2021
Landeszentrum Gesundheit Nordrhein-Westfalen
2013
University of Rostock
2008-2010
Guided Therapy Systems (United States)
2006
Birmingham Children's Hospital
2005
Hershey (United States)
2005
EUROMACS is a registry of the European Association for Cardio-Thoracic Surgery (EACTS) whose purpose to gather clinical data related durable mechanical circulatory support scientific purposes and publish annual reports. Because treatment children with end-stage heart failure has several significantly different characteristics than adults, outcomes interventions are analysed in this dedicated paediatric report.Participating hospitals contributed pre-, peri- long-term postoperative on implants...
Abstract OBJECTIVES A second paediatric report has been generated from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). The purpose of EUROMACS, which is operated by Association Cardio-Thoracic Surgery, to gather data related durable mechanical circulatory support scientific purposes and publish reports respect course therapy. Since first issued, efforts increase compliance participation have extended. Additionally, provided opportunity analyse patients...
Cardiomyopathies might lead to end-stage heart disease with the requirement of drastic treatments like bridging up transplant or transplantation. A not precisely known proportion these diseases are genetically determined. We genotyped 43 index-patients (30 DCM, 10 ARVC, 3 RCM) advanced end stage cardiomyopathy using a gene panel which covered 46 genes. Fifty-three variants possible impact on in 33 patients were identified. Of 27 (51%) classified as likely pathogenic MYH7, MYL2, MYL3, NEXN,...
We aimed to evaluate the feasibility and efficacy of autologous umbilical cord blood mononuclear cell (UCMNC) transplantation on right ventricular (RV) function in a novel model chronic RV volume overload. Four-month-old sheep ( n = 20) were randomized into 10) control groups 10). After assessment baseline by conductance catheter method, transannular patch (TAP) was sutured outflow tract (RVOT). Following infundibulotomy ring pulmonary valve transected without cardiopulmonary bypass. UCMNC...
Various diseases and diversity in implantation ages, together with evolving diagnostic therapeutic options, hinder comparative evaluations of long-term outcomes for valved conduits used reconstruction the right ventricular outflow tract (RVOT). We combined two common evaluation methods to optimally use information obtained by pooling raw data from high volume centers, each very regular follow-up procedures, aim analyzing durability differences between conventional homografts bovine jugular...
We aimed to determine the response of right ventricle (RV) surgically induced pressure and volume overload in both acute chronic settings. Four-month-old sheep were operated via left anterior thoracotomy. Pressure RV was established by banding pulmonary trunk. Volume implantation a transannular patch ventricular outflow tract. Right function obtained with conductance catheters before after surgery as well three months postoperatively. Acute resulted an increase end-systolic (ESV) (P=0.002)...
In the search for a biodegradable device that leaves nothing but tissue of patient after complete endotheliazation and absorption, BioSTAR® was introduced in 2007 (CE Mark European community HPB Canada) ASD PFO closure. It consists metal framework covered by membrane generated from layer porcine collagen is broken down absorbed over time. sheep model, results were promising, showing closure defect with degradation approximately 90% implanted material two years.We report retrospective...
A third paediatric report has been generated from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS). The purpose of EUROMACS, which is operated by Association Cardio-Thoracic Surgery, to gather data related durable mechanical circulatory support scientific purposes and publish reports respect course therapy. Since first issued, efforts increase compliance participation have extended. Additionally, provided opportunity analyse patients younger age lower...
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy Fallot has been linked with favorable right remodeling but adverse outcomes. The aim our study was to assess the hemodynamic impact and prognostic relevance pressure load in this population. Methods Results A total 296 patients repaired (mean age, 17.8±7.9 years) were included a prospective cardiovascular magnetic resonance multicenter study. Myocardial strain quantified by feature tracking technique at...
This retrospective study reviews our results regarding the long-term support in pediatric patients using two ventricular assist systems between January 2008 and April 2014. We implanted Berlin Heart EXCOR 29 (median age 3.4 years [interquartile range (IQR) 0.2-16.5], median weight 13 kg [IQR 4.2-67.2]). Twenty-two (75.8%) received a left device. Three (10.3%) had single-ventricle physiology. One patient (3.4%) mechanical mitral valve prosthesis. The HeartWare System was nine patients. 15.6...
End-stage congenital heart disease (CHD) is an important indication for pediatric transplantation (HTx) as well in adult populations. The purpose of this retrospective analysis was to compare the survival rate adults who underwent HTx end-stage CHD with those other causes. To find out whether a viable therapeutic option patients preoperated CHD, data from 15 different forms had previously undergone corrective and palliative procedures, were retrospectively analyzed compared 1400 (>15 years...
Background: Sinus node dysfunction is a frequent complication of Fontan‐type procedure. Epicardial pacing considered as the standard treatment for these patients. Methods and Results: We evaluated an endocardial approach in seven patients using 4.1 French bipolar lumenless lead (SelectSecure) that positioned through steerable guiding catheter. Either purely transvenous or open transatrial can be used placement. The smallest child weighed 12 kg. Individual anatomy was assessed preimplantation...
Mechanical circulatory support for pediatric heart failure patients with the Berlin Heart EXCOR ventricular assist system is only approved and established bridging strategy recovery or transplantation. In recent years, burden of thromboembolic events has led to modifications recommended antithrombotic therapy. Therefore, we aimed assess practice among European Pediatric Investigator Group members.We sent a questionnaire assessing seven aspects therapy 18 hospitals using device children....
We evaluated 4384 procedures performed between 1957 and 2018, collected in the National Register for Congenital Heart Defects, conducted on 997 patients with 1823 pulmonary valve replacements (PVRs), including 226 implanted via catheter [transcatheter (TCV)]. Main study targets are as follows: TCV benefit, type durability, decade-wise treatment changes procedure frequencies over lifetime of a PVR patient. studied impact surgical replacement (via Kaplan–Meier); type-specific performance...
The Berlin Heart EXCOR (BHE) offers circulatory support across all paediatric ages. Clinically, the necessary care and outcomes differ in various age groups. EUROMACS database was used to study age- size-related for this specific device.All patients <19 years of from supported with a BHE between 2000 November 2021 were included. Maximally selected rank statistics determine body surface area (BSA) cut-off values. Multivariable Cox proportional hazard regression using ridge penalization...
Mepivacaine is a potent local anaesthetic and used for infiltration regional anaesthesia in adults pediatric patients. Intoxications with mepivacaine affect mainly the CNS cardiovascular system. We present case of accidental intravenous application intoxication an infant resulting seizure, broad complex bradyarrhythmia, arterial hypotension finally cardiac arrest. The patient could be rescued by prolonged resuscitations rapid initiation ECMO survived without neurological damage. management...
OBJECTIVES: The Berlin Heart EXCOR® (EXCOR) paediatric ventricular assist device is used worldwide for mechanical support of infants and small children with end-stage heart failure. A clinically important gap between the smallest EXCOR blood pump (10 ml) next larger size (25 limited choice in patients a body surface area (BSA) 0.33 0.5 m2. We present first clinical experience from early product surveillance (EPS) new 15-ml pump. METHODS: After CE U.S. Food Drug Administration approval...
Pressure-volume loop measurements by cardiac catheterization constitute a highly reliable method for the direct beat-to-beat functional analysis of heart. We aimed to prove its feasibility instantaneous evaluation right ventricular performance in novel experimental model pulmonary regurgitation (PR). Four-month-old sheep (n=18, weighing 35-45 kg) were operated via left anterior thoracotomy. A transannular patch (TAP) was sutured outflow tract (RVOT). Pulmonary valve annulus transsected...
Abstract There is ongoing debate regarding the initial management of symptomatic neonates with tetralogy Fallot. Although neonatal repair can be performed low mortality, it associated increased morbidity and long-term impact on right ventricular performance. Traditionally, modified Blalock–Taussig shunt remains palliative procedure choice. Differential pulmonary artery flow may occur subsequently result in underdevelopment distortion vessels. Transcatheter therapy was previously limited to...
Left ventricular rotation is physiologically affected by acute changes in preload. We investigated the effect of preload chronically underloaded and overloaded left ventricles children with shunt lesions.A total 15 patients atrial septal defects (Group A: 7.4 ± 4.7 years, 11 females) 14 patent arterial ducts B: 2.7 3.1 10 were using 2D speckle-tracking echocardiography before after interventional catheterisation. The rotational parameters patient group compared those 29 matched healthy...