A5081430404- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Cardiovascular and Diving-Related Complications
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Vascular anomalies and interventions
- Renal and Vascular Pathologies
- Cardiovascular Conditions and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
The University of Melbourne
2016-2025
Children's National
2020-2025
George Washington University
2020-2025
National Hospital
2022-2025
St Vincent's Hospital Sydney
2025
The University of Sydney
2025
Royal Children's Hospital
2015-2024
George Washington University Hospital
2023-2024
Walter and Eliza Hall Institute of Medical Research
2024
Cleveland Clinic
2024
The life expectancy of patients undergoing a Fontan procedure is unknown.Follow-up all 1006 survivors the 1089 who underwent in Australia and New Zealand was obtained from binational population-based registry including pediatric adult cardiac centers. There were 203 atriopulmonary connections (AP; 1975-1995), 271 lateral tunnels (1988-2006), 532 extracardiac conduits (1997-2010). proportion with hypoplastic left heart syndrome increased 1/173 (1%) before 1990 to 80/500 (16%) after 2000....
To determine whether patients undergoing the lateral tunnel and extracardiac conduit modifications of Fontan procedure have better outcomes than a classical atriopulmonary connection.Between 1980 2000, 305 consecutive underwent at our institution. There were 10 hospital deaths (mortality: 3%) with no death after 1990. Independent risk factors for mortality preoperative elevated pulmonary artery pressures (P=0.002) common atrioventricular valve (P=0.04). was taken down during stay in 7...
Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human cells. They are usually defined using combinations non-lineage-specific (surrogate) markers such as anti-TRAV1-2, CD161, IL-18Rα and CD26. The development MR1-Ag tetramers now permits the specific identification MAIT based on T-cell receptor specificity. Here, we compare these approaches for identifying show that surrogate not always accurate in cells, particularly CD4+ fraction. Moreover, while all cell...
To identify factors associated with hospital and long-term outcomes in a binational cohort of extracardiac conduit (ECC) Fontan recipients. All patients who underwent an ECC procedure from 1997 to 2010 Australia New Zealand were identified, perioperative, follow-up, echocardiographic reintervention data collected. Risk for early late mortality, failure adverse analysed. A total 570 follow-up was available 529 patients. The mean 6.7 years (standard deviation: 3.5) completeness the 98%. There...
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These develop intrathymically through three-stage process, but events that regulate this are largely unknown. Here, using bulk and single-cell RNA sequencing-based transcriptomic analysis mice humans, we studied changing transcriptional landscape accompanies transition each stage. Many transcripts were sharply modulated during MAIT cell development, including SLAM (signaling lymphocytic...
Abstract Aims The Fontan operation has resulted in improved survival patients with single‐ventricle congenital heart disease. As a result, there is growing population of teenagers and adults circulation. Many co‐morbidities have been increasingly recognized this due to the unique features Standardization how co‐morbid conditions are defined will help facilitate understanding, consistency interpretability research clinical experience. Unifying common language usage critical precursor step for...
In children undergoing heart surgery, nitric oxide administered into the gas flow of cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output syndrome, leading to improved recovery and shorter duration respiratory support. It remains uncertain whether improves ventilator-free days (days alive free from mechanical ventilation).
This paper was undertaken to determine the long-term outcome of active infective endocarditis treated with antibiotic and radical excision infected tissues by surgery.From October 1978 August 1994, 122 consecutive patients were operated on during acute phase endocarditis. There 85 men 37 women whose mean age 50 years, ranging from 20 79. Surgery needed because one or more following complications: cardiogenic/septic shock in 19 patients, congestive heart failure 68, persistent sepsis 64,...