A5015864840- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Xenotransplantation and immune response
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Tracheal and airway disorders
- Vascular anomalies and interventions
- Cardiac tumors and thrombi
- Cardiovascular Issues in Pregnancy
- Organ Transplantation Techniques and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Venous Thromboembolism Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
University Hospital of Bern
2016-2025
University of Bern
2016-2025
Adult Congenital Heart Association
2024
San Diego Cardiac Center
2017
Barro Colorado Island
2015
University Children’s Hospital Bern
2014
University of Zurich
2003-2013
University Children's Hospital Zurich
2005-2013
Center for Pediatric Endocrinology Zurich
2004-2013
West Virginia University
2005-2011
Background We previously demonstrated the successful tissue engineering and implantation of functioning autologous heart valves based on vascular-derived cells. Human marrow stromal cells (MSC) exhibit potential to differentiate into multiple cell-lineages can be easily obtained clinically. The feasibility creating engineered (TEHV) from MSC as an alternative cell source, impact a biomimetic in vitro environment differentiation was investigated. Methods Results were isolated, expanded...
Transcatheter aortic valve implantation (TAVI) for high-risk and inoperable patients with severe stenosis is an emerging procedure in cardiovascular medicine. Little known of the impact TAVI on renal function.We analysed retrospectively baseline characteristics outcome 58 including 2 chronic haemodialysis undergoing at our institution. Acute kidney injury (AKI) was defined according to RIFLE classification.Fifty-eight symptomatic not considered suitable conventional surgical replacement a...
Coronary artery disease (CAD) is frequently present in patients with severe aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI). While revascularisation affects peri-operative outcome surgical replacement, the impact of percutaneous coronary intervention (PCI) TAVI not well established.Consecutive AS were prospectively included into Bern registry. In CAD, myocardium at risk was assessed using DUKE myocardial jeopardy score. Revascularisation performed by means PCI either...
Due to better early and long-term outcome, the increasing population of grown-ups with congenital heart disease (GUCH) brings up unexpected quality life (QoL) issues. The cardiac lesion by itself is not always major problem for these patients, since issues pertaining QoL psychosocial aspects often predominate. This study analyses GUCH patients after surgery possible impact medical complications.A questionnaire package containing SF-36 health survey (health related QoL), HADS test...
The treatment of massive pulmonary embolism (PE) is a matter debate. We present our institutional experience patients suffering from PE with the aim comparing early results, outcome and quality life (QoL) between primarily assigned to either surgical embolectomy (SE) or thrombolytic therapy (TL). A subgroup (TS) failed responses TL requiring SE was separately analysed. All consecutive (January 2001–December 2007) computed tomography (CT)-scan-confirmed bilateral central paracentral were...
The aim of the current study was to investigate incidence and causes surgical interventions in primarily nontreated aortic segments after previous repair patients with Marfan syndrome.Retrospective analysis 86 consecutive syndrome fulfilling Ghent criteria that underwent 136 surgeries were followed at this institution past 15 years. Mean follow-up 8.8±6.8 y. Thirty-day, 6-month, 1-year, overall mortality 3.5%, 5.8%, 7.0%, 12.8%, respectively. Ninety-two percent initially presented root,...
The advent of normothermic, ex-situ heart perfusion (ESHP) enables new options for evaluation cardiac grafts. Donation after circulatory death (DCD) is a promising solution to improve transplantation rates, but current ESHP approaches are recognized as suboptimal DCD We aimed develop vascular function test graft assessment during using porcine model DCD. Explanted hearts were perfused unloaded 3 hours followed by left ventricular loading 1 hour measure recovery. During perfusion, hypercapnic...
Tissue engineering represents a promising approach to in vitro creation of living, autologous replacements with the potential grow, repair, and remodel. Particularly congenital operation, there is substantial need for such implantation materials. We previously demonstrated fabrication completely autologous, functional heart valves on basis peripheral vascular cells. Presently feasibility creating pulmonary artery conduits from human umbilical cord cells was investigated.Human were harvested...
Objective: Tissue engineering of viable, autologous cardiovascular replacements with the potential to grow, repair and remodel represents an attractive approach overcome shortcomings available for congenital cardiac defects. Currently, vascular myofibroblast cells represent established cell source tissue engineering. Cell isolation requires invasive harvesting venous or arterial vessel segments prior scaffold seeding, a technique which may not be preferable, especially in pediatric patients....
The aim of this study was to investigate whether total arch replacement (TAR) during initial surgery for root aneurysm should be routinely performed in patients with Marfan syndrome (MFS).Retrospective analysis 94 consecutive MFS fulfilling Ghent criteria who underwent 148 aortic surgeries and were followed at institution the past 16 years.The mean follow-up interval 8.8 ± 7 years. Initial presentation acute dissection (AAD) 35% (76% Type A 24% B) aneurysmal disease 65%. TAR 8% AAD...
Atrioventricular conduction abnormalities (AVCA) may complicate transcatheter aortic valve implantation (TAVI) and surgical replacement (SAVR). The aim of this study was to prospectively evaluate AVCA after TAVI SAVR.Among 50 patients undergoing 25 SAVR a continuous 7-day Holter electrocardiogram (ECG) recorded the procedure. ECGs during 12-lead before 1 7 days were analyzed. At baseline, older (mean 82.1 vs 75.4, P < 0.001), had longer PR interval (median 200 milliseconds 175 milliseconds,...