A5018515779- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- ECG Monitoring and Analysis
- Vitamin C and Antioxidants Research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Health and Disease Prevention
- Diagnosis and Treatment of Venous Diseases
- Cardiac Valve Diseases and Treatments
- Retinoids in leukemia and cellular processes
- Coronary Interventions and Diagnostics
- Ion channel regulation and function
- Heart Rate Variability and Autonomic Control
- Folate and B Vitamins Research
- Cardiomyopathy and Myosin Studies
- Sports injuries and prevention
- Vasculitis and related conditions
- Metabolism and Genetic Disorders
- Vitamin K Research Studies
- Vestibular and auditory disorders
- Mitochondrial Function and Pathology
University of Fribourg
2016-2025
Hirslanden Clinique Cecil
2011-2024
Hôpital de l'enfance
2010-2019
University Hospital of Bern
2007-2016
University of Bern
2005-2016
Erasmus MC
2015
University Medical Center Groningen
2009-2015
Haga Hospital
2015
University of Padua
2014
University Hospital of Zurich
2014
Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate blood pressure has antiadrenergic potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events high-risk permanent fibrillation.We assigned patients who were at least 65 years of age with a 6-month history fibrillation risk factors for to receive placebo. The first coprimary outcome was stroke, myocardial...
Background — Extensive lines of radiofrequency (RF) lesions through infarct (MI) can ablate multiple and unstable ventricular tachycardias (VTs). Methods for guiding ablation that minimize unnecessary RF applications are needed. This study assesses the feasibility line placement by mapping to identify a reentry circuit isthmus. Results Catheter were performed in 40 patients (MI location: inferior, 28; anterior, 7; both, 5) with an electroanatomic system measure region lines. The initial was...
The purpose of this Consensus Statement is to provide a state-of-the-art review the field catheter ablation ventricular tachycardia (VT), and report findings Task Force, convened by European Heart Rhythm Association (EHRA) Society (HRS) that was charged with defining indications, techniques, outcomes procedure. This statement summarizes opinion Force members based on their own experience in treating patients, as well literature. It directed all healthcare professionals who treat patients are...
Risk stratification scheme. aiming at assessing the risk of VAs and SCD in patients with MVP, involving two phases based on clinical imaging context uncovered arrhythmia. In absence ventricular tachycardia, phenotypic features will trigger intensity screening for Green boxes indicate green heart consensus statements yellow statements. High - sustained VT, polymorphic NSVT, fast (>180 bpm) VT/NSVT resulting syncope. ICD = implantable cardioverter defibrillator; LA left atrium; LGE late...
AimsFive desmosomal genes have been recently implicated in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) but the clinical impact of genetics remains poorly understood. We wanted to address potential genotyping.
For patients having suffered ischemic stroke, the current diagnostic strategies often fail to detect atrial fibrillation as a potential cause of embolic events. The aim study was identify paroxysmal in stroke patients. We hypothesized that with frequent premature beats (APBs) recorded 24-hour ECG will show more when followed by repeated long-term recordings than without or infrequent APBs.127 acute and known AF were enrolled prospective AF. Patients stratified according number APBs (> =70...
In patients with drug-resistant hypertension, chronic electric stimulation of the carotid baroreflex is an investigational therapy for blood pressure reduction. We hypothesized that changes in cardiac autonomic regulation can be demonstrated response to baroreceptor stimulation, and we analyzed correlation changes. Twenty-one hypertension were prospectively included a substudy Device Based Therapy Hypertension Trial. Heart rate variability heart turbulence using 24-hour ECG. Recordings...
The value of standard 2-dimensional transthoracic echocardiographic parameters for risk stratification in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is controversial.We investigated the impact RV fractional area change (FAC) and tricuspid annulus plane systolic excursion (TAPSE) prediction major adverse cardiovascular events (MACE) defined as occurrence cardiac death, heart transplantation, survived sudden fibrillation, sustained tachycardia, or syncope....
Background— Ventricular tachycardia (VT) isthmuses can be defined by fixed or functional block. During sinus rhythm, pace mapping near the exit of an isthmus should produce a QRS similar to that VT. Pace at sites proximal may with longer stimulus-to-QRS interval (S-QRS). The aim study was determine whether VT could identified and followed mapping. Methods Results— Left ventricular during rhythm performed 819 in 11 patients late after infarction, corresponding CARTO maps were reconstructed....
Ventricular Tachycardia Ablation, Introduction . Sustained monomorphic ventricular tachycardia (VT) associated with nonischemic cardiomyopathy (CMP) is uncommon. Optimal approaches to catheter mapping and ablation are not well characterized, but they likely depend on the VT mechanism. The purpose of this study was evaluate mechanisms sustained encountered in CMP assess feasibility, safety, efficacy radiofrequency for treatment. Methods Results : Twenty‐six consecutive patients referred...
Background —Saline cooling of the electrode during radiofrequency (RF) ablation increases lesion size in animal models. If cooled RF also human infarcts, it should facilitate termination ventricular tachycardia (VT). Methods and Results —In 66 patients with VT due to prior infarction, 366 sites, which were classified by entrainment isolated potentials followed either standard energy (247 sites) or (119 sites), retrospectively reviewed compare efficacy for terminating VT. was applied at 259...
In patients with Ebstein's anomaly (EA) arrhythmias are frequently encountered. Although most can be targeted catheter ablation, specific issues render the procedure more challenging in EA. This study examines mechanisms of different related to EA and outcome after ablation.Clinical procedural data ablation 4 European centers were analyzed. 32 (mean age 24 ± 15 years), 34 accessory pathways (APs), 8 intra-atrial reentry tachycardias (IART), 5 cavotricuspid isthmus-dependent atrial flutter...
The incidence of atrial fibrillation (AF) is rising in the aging patients with congenital heart defects (CHD). However, studies reporting on AF CHD are scarce. aim this multicenter study was to examine a large cohort variety CHD: (1) age onset and initial treatment AF, coexistence tachyarrhythmia (2) progression paroxysmal (long-standing) persistent/permanent during long-term follow-up.Patients (n=199) 15 different documented episodes were studied. developed at 49±17 years. Regular...
Monomorphic ventricular tachycardias associated with regions of scar are most commonly due to reentry. Catheter based techniques have recently been described for mapping reentry circuits. Fluoroscopic methods obvious limitations when attempting map large circuit and localize target‐sites radiofrequency ablation. Three‐dimensional right endocardial was performed in a 38‐year‐old patient tachycardia 28 years after surgical correction tetralogy Fallot by using the CARTO electroanatomical...
Brugada syndrome (BS) is an inherited electrical cardiac disorder characterized by right bundle branch block pattern and ST segment elevation in leads V1 to V3 on surface electrocardiogram that can potentially lead malignant ventricular tachycardia sudden death. About 20% of patients have mutations the only so far identified gene, SCN5A, which encodes alpha-subunit human voltage-dependent sodium channel (hNa(v)1.5). Fever has been shown unmask or trigger BS phenotype, but associated...
Background: Atrial fibrillation (AF) ablation is less frequently performed in women than men. Although the prevalence of AF slightly higher men, this does not fully account for lower number ablations women. This study sought to examine effect gender on referral and subsequent management. Methods: Consecutive patients referred our tertiary arrhythmia outpatient clinic management were retrospectively analyzed. Results: Of 264 referred, only 27% Women older men (63 ± 9 vs 58 11 years, P =...