A5029683685- Electronic Health Records Systems
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Healthcare Systems and Technology
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Emergency and Acute Care Studies
- Food Security and Health in Diverse Populations
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Geriatric Care and Nursing Homes
- Data Quality and Management
- Parathyroid Disorders and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Public Health Policies and Education
- Cardiac electrophysiology and arrhythmias
- Mobile Health and mHealth Applications
- Data-Driven Disease Surveillance
- Health Literacy and Information Accessibility
- Peptidase Inhibition and Analysis
- Telemedicine and Telehealth Implementation
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Neuroendocrine Tumor Research Advances
- Eosinophilic Disorders and Syndromes
- Radiology practices and education
Regenstrief Institute
2016-2025
Indiana University – Purdue University Indianapolis
2016-2025
Alnylam Pharmaceuticals (United States)
2015-2025
Sidney & Lois Eskenazi Hospital
2018-2025
Indiana University Indianapolis
2020-2024
Centro de Investigación Biomédica en Red
2024
University College London
2023-2024
Centro de Investigación en Red en Enfermedades Cardiovasculares
2024
British Heart Foundation
2024
Boston University
2024
Ventricular arrhythmias can cause sudden cardiac death (SCD) in patients with normal hearts and those underlying disease such as heart failure. In animals failure inherited forms of exercise-induced SCD, depletion the channel-stabilizing protein calstabin2 (FKBP12.6) from ryanodine receptor–calcium release channel (RyR2) complex causes an intracellular Ca 2+ leak that trigger fatal arrhythmias. A derivative 1,4-benzothiazepine (JTV519) increased affinity for RyR2, which stabilized closed...
Object. The objective of this study was to identify specific independent risk factors for surgical site infections (SSIs) occurring after laminectomy or spinal fusion. Methods. authors performed a retrospective case-control data obtained in patients between 1996 and 1999 who had undergone and/or Forty-one with SSI meningitis were identified, compared those acquired 178 uninfected control patients. Risk determined using univariate analyses multivariate logistic regression. surgery—related...
Background: Hereditary transthyretin-mediated (hATTR) amyloidosis is a rapidly progressive, multisystem disease that presents with cardiomyopathy or polyneuropathy. The APOLLO study assessed the efficacy and tolerability of patisiran in patients hATTR amyloidosis. effects on cardiac structure function prespecified subpopulation evidence amyloid involvement at baseline were assessed. Methods: was an international, randomized, double-blind, placebo-controlled phase 3 trial Patients randomized...
Recent federal policies and actions support the adoption of health information exchange (HIE) in order to improve healthcare by addressing fragmented personal information. However, concerted efforts at facilitating HIE have existed for over two decades this country. The lessons these experiences include a recurrence barriers challenges beyond those associated with technology. Without new strategies, current methods may not address barriers.
Defective regulation of the cardiac ryanodine receptor (RyR2)/calcium release channel, required for excitation-contraction coupling in heart, has been linked to arrhythmias and heart failure. For example, diastolic calcium “leak” via RyR2 channels sarcoplasmic reticulum identified as an important factor contributing impaired contractility failure ventricular that cause sudden death. In patients with failure, chronic activation “fight or flight” stress response leads protein kinase A (PKA)...
Background— Ca 2+ leak from the sarcoplasmic reticulum (SR) may play an important role in triggering and/or maintaining atrial arrhythmias, including fibrillation (AF). Protein kinase A (PKA) hyperphosphorylation of cardiac ryanodine receptor (RyR2) resulting dissociation channel-stabilizing subunit calstabin2 (FK506-binding protein or FKBP12.6) causes SR failing hearts and can trigger fatal ventricular arrhythmias. Little is known about RyR2 dysfunction AF, however. Methods Results— Left...
The study objective was to assess the effect of vutrisiran, an RNA interference therapeutic that reduces transthyretin (TTR) production, in patients with hereditary (ATTRv) amyloidosis polyneuropathy.HELIOS-A a phase 3, global, open-label comparing efficacy and safety vutrisiran external placebo group (APOLLO study). Patients were randomized 3:1 subcutaneous 25 mg every 3 months (Q3M) or intravenous patisiran 0.3 mg/kg weeks (Q3W) for 18 months.HELIOS-A enrolled 164 (vutrisiran, n = 122;...
Transthyretin amyloidosis, also called ATTR is associated with accumulation of amyloid deposits in the heart and commonly manifests as progressive cardiomyopathy. Patisiran, an RNA interference therapeutic agent, inhibits production hepatic transthyretin. Download a PDF Research Summary. In this phase 3, double-blind, randomized trial, we assigned patients hereditary, known variant, or wild-type cardiac 1:1 ratio, to receive patisiran (0.3 mg per kilogram body weight) placebo once every 3...
Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin.
HELIOS-A was a Phase 3, open-label study of vutrisiran, an RNA interference therapeutic, in patients with hereditary transthyretin (ATTRv) amyloidosis polyneuropathy. This analysis evaluated vutrisiran's impact on exploratory cardiac endpoints patients.
Background— Chronic β-adrenergic receptor (β-AR) blockade improves cardiac contractility and prolongs survival in patients with heart failure; however, the mechanisms underlying these favorable responses are poorly understood. Stress-induced activation of sympathetic nervous system results protein kinase A (PKA)-mediated phosphorylation calcium (Ca 2+ ) release channel/cardiac ryanodine (RyR2), required for excitation-contraction (EC) coupling, activating RyR2 channel, increasing...
Vutrisiran (ALN‐TTRsc02) is a liver‐directed, investigational, small interfering ribonucleic acid drug for the treatment of transthyretin (TTR)‐mediated amyloidosis. This phase I, randomized, single‐blind, placebo‐controlled, single ascending dose study evaluated pharmacodynamics, pharmacokinetics, and safety profile subcutaneously administered vutrisiran (5–300 mg) in healthy subjects ( n = 80). achieved potent sustained TTR reduction dose‐dependent manner, with mean maximum 57–97%,...
Objective Health information exchange (HIE) is the process of electronically sharing patient-level between providers. However, where implemented, reports indicate HIE system usage low. The aim this study was to determine factors associated with different types usage.
Abstract Purpose The Phase 3 ENDEAVOUR study evaluated revusiran, an investigational RNA interference therapeutic targeting hepatic transthyretin (TTR) production, for treating cardiomyopathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis. Methods Patients with hATTR amyloidosis were randomized 2:1 to receive subcutaneous daily revusiran 500 mg ( n = 140) or placebo 66) 5 days over a week followed weekly doses. Co-primary endpoints 6-min walk test distance and serum TTR...
Patients with cardiac amyloidosis demonstrate reduced myocardial strain associated sparing of the apex. In APOLLO randomized clinical trial, patisiran, an RNA interference therapeutic that inhibits transthyretin synthesis, improved left ventricular (LV) global longitudinal (LV GLS) compared placebo in patients hereditary transthyretin-mediated (hATTR) polyneuropathy and evidence involvement.To evaluate treatment association patisiran regional LV manifestation hATTR amyloidosis.This...
SUMMARY Ethnic minority and low-income populations have the highest rates of cardiovascular disease lowest leisure-time physical activity. Because activity reduces risk premature death disability from disease, researching correlates to such in these is an important aspect health promotion US. To identify environmental, policy, cultural barriers women, The Women's Cardiovascular Health Network Project conducted focus groups with White, African American, Latina, American Indian women aged...