A5081928873- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Medical Imaging and Pathology Studies
- Cardiovascular Function and Risk Factors
- Neuroendocrine Tumor Research Advances
- Cardiomyopathy and Myosin Studies
- Spectroscopy and Quantum Chemical Studies
- Cell Adhesion Molecules Research
- Lanthanide and Transition Metal Complexes
- Molecular Junctions and Nanostructures
- Photochemistry and Electron Transfer Studies
- Cancer, Hypoxia, and Metabolism
- Fullerene Chemistry and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Peptidase Inhibition and Analysis
- Photosynthetic Processes and Mechanisms
- Free Radicals and Antioxidants
- Cardiac pacing and defibrillation studies
- Sarcoidosis and Beryllium Toxicity Research
- Health Systems, Economic Evaluations, Quality of Life
- Chemokine receptors and signaling
- thermodynamics and calorimetric analyses
- NF-κB Signaling Pathways
- Williams Syndrome Research
- Metabolism, Diabetes, and Cancer
Vanderbilt University Medical Center
2015-2024
University of Tennessee Medical Center
2024
University of Tennessee at Knoxville
2024
VA Tennessee Valley Healthcare System
2024
Vanderbilt University
2008-2023
Vanderbilt Health
2020
Harvard University
1991-2002
Brigham and Women's Hospital
2002
Massachusetts General Hospital
2000-2002
University of Pittsburgh
1999
Transthyretin amyloidosis, also called ATTR is associated with accumulation of amyloid deposits in the heart and commonly manifests as progressive cardiomyopathy. Patisiran, an RNA interference therapeutic agent, inhibits production hepatic transthyretin. Download a PDF Research Summary. In this phase 3, double-blind, randomized trial, we assigned patients hereditary, known variant, or wild-type cardiac 1:1 ratio, to receive patisiran (0.3 mg per kilogram body weight) placebo once every 3...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA precise determination of the triplet energy carbon (C60) by photoacoustic calorimetryRebecca R. Hung and Joseph J. GrabowskiCite this: Phys. Chem. 1991, 95, 16, 6073–6075Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/j100169a007https://doi.org/10.1021/j100169a007research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.alpha.-Amino aldehyde equivalents as substrates for rabbit muscle aldolase: synthesis of 1,4-dideoxy-D-arabinitol and 2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidineRebecca R. Hung, Julie Ann Straub, George M. WhitesidesCite this: J. Org. Chem. 1991, 56, 12, 3849–3855Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June...
Abstract Aims Cardiac amyloidosis (CA) is associated with increased mortality due to arrhythmias, heart failure, and electromechanical dissociation. However, the role of an implantable cardioverter-defibrillator (ICD) remains unclear. We conducted case-control study assess survival in CA patients without a primary prevention ICD compared outcomes age, sex, device implant year-matched non-CA group ICD. Methods results There were 91 subjects [mean age= 71.2 ± 10.2, female 22.0%, 49 AL Mayo...
Background and Aims: Genetic testing is recommended for select patients with atrial fibrillation (AF). The aims of this study were to define the results genetic evaluation its therapeutic impact referred a dedicated AF precision medicine clinic. Methods: Patients diagnosed before age 60 candidates referral. In addition standard history, physical exam, ECG, included 3-generation pedigree, cardiac imaging, ambulatory monitoring, clinical cardiomyopathy/arrhythmia panel. Results: 264...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnthalpy measurements in organic solvents by photoacoustic calorimetry: a solution to the reaction volume problemRebecca R. Hung and Joseph J. GrabowskiCite this: Am. Chem. Soc. 1992, 114, 1, 351–353Publication Date (Print):January 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ja00027a050https://doi.org/10.1021/ja00027a050research-articleACS PublicationsRequest reuse...
Chemokines such as the monocyte chemol attractant protein-1 (MCP-1) convert rolling to firm arrest under physiological flow conditions via integrin activation and simultaneously activate phosphoinositide 3-kinase (PI3K). Here we used adenoviral gene transfer biochemical inhibitors manipulate PI3K-dependent pathways in human monocytes. In vitro lipid kinase assays from purified monocytes, showed that MCP-1 activates "classical" PI3Kalpha pathway not PI3Kgamma, a PI3K isoform thought be...
The modern technique of photoacoustic calorimetry (PAC) has been critically evaluated for its utility and reliability in biophysical chemistry by applying it to reactive intermediates the vitamin B12 family compounds. Measurement signals at 337 nm 0.01 M phosphate buffer pH 7.0, methylcobalamin methylcobinamide versus reference compounds from −2 +40 °C, combined with measurement quantum yields photodissociation (0.27 0.17, respectively), bond dissociation energies corresponding cobalt−carbon...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharge transfer state photophysics in a rigid molecule: competition between electron processes the Marcus normal and inverted regionsJoseph Morais, Rebecca R. Hung, Joseph J. Grabowski, Matthew B. ZimmtCite this: Phys. Chem. 1993, 97, 50, 13138–13144Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://doi.org/10.1021/j100152a017RIGHTS & PERMISSIONSArticle...
Introduction: The Phase 3 APOLLO-B study evaluates patisiran in patients (pts) with transthyretin (ATTR) cardiac amyloidosis over a 12-month (M) double-blind (DB) period, followed by an open-label extension (OLE) period when all pts receive (NCT03997383). Hypothesis: Patisiran provides long-term benefit ATTR amyloidosis. Aims: Describe safety and efficacy of during the OLE (18M+). Methods: Pts (18-85 yrs) heart failure history were randomized 1:1 to or placebo (pbo). completing DB eligible...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical profile of the dehydrogenases Drosophila melanogasterRudolf K. Allemann, Rebecca. Hung, and Steven A. BennerCite this: J. Am. Chem. Soc. 1988, 110, 16, 5555–5560Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://doi.org/10.1021/ja00224a046RIGHTS & PERMISSIONSArticle Views94Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are COUNTER-compliant sum full...
conditions associated with sudden death (e.g., unexplained in epilepsy) to identify P/LP variants and correlated genotypes postmortem phenotypes 2) evaluated family history of decedents high-risk phenotypes: premature CAD, aortic aneurysm dissection, cardiomyopathy [CM], arrhythmogenic right ventricular CM, hypertrophic bicuspid valve, primary electrical.Results: Between 02/2011 01/2018, 856 pSCD (66% CV causes, 34% non-CV) were autopsied; 306 (36%) consented genetic testing (mean age 62...
7572 Background: Systemic AL amyloidosis can lead to progressive multi-organ dysfunction including advanced heart failure which may require orthotopic transplantation (OHT). Hematologic outcomes of post-OHT are not well described. Methods: We report for patients with cardiac involvement from Nov 2008 - Jun 2023 at Vanderbilt University Medical Center. response was graded per the ISA guidelines. Results: Fourteen pts underwent OHT whom 13 had lambda light chain disease. Three (21%) isolated...