A5007266047- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Health Systems, Economic Evaluations, Quality of Life
- Sarcoidosis and Beryllium Toxicity Research
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Orthopedic Infections and Treatments
- Mechanical Circulatory Support Devices
- RNA and protein synthesis mechanisms
- Coronary Interventions and Diagnostics
- VLSI and Analog Circuit Testing
- Acute Ischemic Stroke Management
- Neuroscience and Neural Engineering
- Eosinophilic Disorders and Syndromes
- Innovative Microfluidic and Catalytic Techniques Innovation
Vanderbilt University Medical Center
2016-2025
Vanderbilt Health
2017-2025
Vanderbilt University
2014-2024
Agaplesion Markus Hospital
2024
Cleveland Clinic
2024
Hamilton Health Sciences
2024
Western University
2024
Population Health Research Institute
2024
McGill University Health Centre
2024
Montreal Heart Institute
2024
Oral anticoagulation is recommended after ablation for atrial fibrillation among patients at high risk stroke. Left appendage closure a mechanical alternative to anticoagulation, but data regarding its use are lacking.
Abstract Aims Failure of radiofrequency (RF) ablation ventricular arrhythmias is often due to inadequate lesion size. Irrigated RF with half-normal saline (HNS) has the potential increase size and reduce sodium delivery patient if same volume irrigant were used for normal (NS) HNS but could risks related steam pops This study aims assess periprocedural complications acute outcome HNS. Methods results Prospective assessment outcomes was performed in 1024 endocardial and/or epicardial...
Efficacy of Bio‐Absorbable Antibacterial Envelope Introduction Cardiac implantable electronic device (CIED) infections are potentially preventable complications associated with high morbidity, mortality, and cost. A recently developed bio‐absorbable antibacterial envelope (TYRX™‐A) might prevent CIED in high‐risk subjects. However, data regarding safety efficacy have not been published. Methods Results In a single‐center retrospective cohort study, we compared the prevalence among subjects...
BackgroundPatients with ventricular tachycardia and ischemic cardiomyopathy are at high risk for adverse outcomes. Catheter ablation is commonly used when antiarrhythmic drugs do not suppress tachycardia. Whether catheter more effective than as a first-line therapy in patients uncertain.MethodsIn an international trial, we randomly assigned 1:1 ratio previous myocardial infarction clinically significant (defined storm, receipt of appropriate implantable cardioverter–defibrillator [ICD] shock...
Background Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers cardiac remodeling, their ability to improve prediction when added a clinical model. Methods Results Blood samples collected before de novo catheter were analyzed. Levels bone morphogenetic protein‐10, angiopoietin‐2, fibroblast growth factor‐23, insulin‐like factor‐binding protein‐7, myosin‐binding protein C3, differentiation factor‐15,...
Ablation of ventricular tachycardia (VT) is limited by the inability to create penetrating lesions reach intramyocardial origins. Intramural needle ablation using in-catheter, heated saline-enhanced radio frequency (SERF) energy uses convective heating increase heat transfer and produce deeper, controllable at intramural targets. This first-in-human trial was designed evaluate safety efficacy SERF in patients with refractory VT.
BACKGROUND: Catheter ablation of ventricular arrhythmias, one the most rapidly growing procedures in cardiac electrophysiology, is associated with magnetic resonance imaging–detected brain lesions more than half cases. Although a retrograde aortic approach conventional, modern tools enable entry through transseptal that may avoid embolization debris from arterial system. We sought to test hypothesis puncture would mitigate injury compared approach. METHODS: The TRAVERSE trial (Transseptal...
Ventricular tachycardia (VT) with a 1:1 V-His relation can be seen in bundle branch reentry (BBR) or passive retrograde activation from scar-related VT (SRR-VT) using left ventricular (LV) Purkinje fascicles (FPVT). To review the frequency that occurs and identify differentiating characteristics of these arrhythmias, including new measures obtained during right (RV) pacing based on orthodromic His-proximal potential (HisRB) capture stimulus to HisRB (S-HisRB) interval approximating RV...
Background and Aims: Genetic testing is recommended for select patients with atrial fibrillation (AF). The aims of this study were to define the results genetic evaluation its therapeutic impact referred a dedicated AF precision medicine clinic. Methods: Patients diagnosed before age 60 candidates referral. In addition standard history, physical exam, ECG, included 3-generation pedigree, cardiac imaging, ambulatory monitoring, clinical cardiomyopathy/arrhythmia panel. Results: 264...
Subclinical atrial fibrillation (AF), in the form of cardiac implantable device-detected high rate episodes (AHREs), has been associated with increased thromboembolism. An cardioverter-defibrillator (ICD) lead a floating dipole may permit single (DX) ICD system to detect AHREs. We sought assess utility DX for subclinical AF detection patients, prospective multicenter, cohort-controlled trial.One hundred fifty patients without prior history (age 59 ± 13 years; 108 [72%] male) were enrolled...
Initiation of ventricular tachycardia (VT) by programmed electrical stimulation (PES) has an important role to allow mapping and assess ablation end points. We hypothesized that substrate may alter VT inducibility mechanical bumping critical sites.Subjects with left scar-related was inducible PES who were undergoing included. repeated after (Group I) or time under sedation/anesthesia during which additional imaging transeptal puncture performed without II). The response the second...
Irrigated radiofrequency ablation with half-normal saline can potentially increase lesion size but may the risk of steam pops emboli or perforation. We hypothesized that would be preceded by intracardiac echocardiography (ICE) findings as well a large impedance fall.
One operative approach to the mitral valve, superior transseptal incision, is proarrhythmic because of extensive atriotomies. The objective this study describe complex atrial tachycardias (ATs) that occur after and propose methods verify lines block as an end point for catheter ablation.Of 69 patients who had electrophysiological studies AT valve surgery, 20 prior incisions. Of these, 14 ATs involving lateral right atrium (RA). There were 9 dual-loop, 4 single-loop, 1 focal tachycardias....
Percutaneous pericardial access for catheter ablation is associated with a bleeding risk. We sought to elucidate the relation of hemorrhagic and thromboembolic events epicardial procedures anticoagulation strategy.Anticoagulation strategy before during 355 patients (57±14 years old) who had ventricular arrhythmia mapping were reviewed. Oral anticoagulants stopped perioperatively heparin administered procedure. Pericardial >80 mL was considered significant. The divided into 3 groups per...
Abstract Background Nonchicken wing left atrial appendage (LAA) morphology is associated with higher risk for stroke in patients fibrillation (AF) than chicken (CW) morphology. Objective Assess whether LAA predicts the formation of thrombus independent age, sex, presenting rhythm, ventricular ejection fraction (LVEF), or anticoagulant use. Methods A cross‐sectional analysis was performed on prospectively enrolled Vanderbilt Registry transesophageal echocardiogram (TEE) between January 1,...