A5003899925- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Adenosine and Purinergic Signaling
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Pain Management and Treatment
- ECG Monitoring and Analysis
- Genetic Associations and Epidemiology
- Cardiac Arrest and Resuscitation
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Pain Management
- Sports injuries and prevention
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Anesthesia and Sedative Agents
- Cardiac tumors and thrombi
Hospital of the University of Pennsylvania
2016-2025
University of Pennsylvania
2016-2025
RELX Group (United States)
2024
RELX Group (United Kingdom)
2024
University of Chicago
2023
Pennsylvania Hospital
2021-2022
Philadelphia University
2022
St. Vincent Hospital
2021
University of Washington
2021
University of Pennsylvania Health System
2021
Early studies suggest that coronavirus disease 2019 (COVID-19) is associated with a high incidence of cardiac arrhythmias. Severe acute respiratory syndrome 2 infection may cause injury to myocytes and increase arrhythmia risk.The purpose this study was evaluate the risk arrest arrhythmias including incident atrial fibrillation (AF), bradyarrhythmias, nonsustained ventricular tachycardia (NSVT) in large urban population hospitalized for COVID-19. We also evaluated correlations between...
Metabolomics, at the heart With failure a leading cause of death, better understanding metabolic function in is welcome advance. Murashige et al. measured more than 270 metabolites using liquid chromatography–mass spectrometry human blood samples taken from an artery entering and vein leaving it. Differences thus reflected processes work heart. Their results confirmed that hearts voraciously consume fatty acids. Hearts secreted, rather consumed, amino acids, revealing active proteolysis. In...
Background: Conscious sedation is used during transcatheter aortic valve replacement (TAVR) with limited evidence as to the safety and efficacy of this practice. Methods: The National Cardiovascular Data Registry Society Thoracic Surgeons/American College Cardiology Transcatheter Valve Therapy was characterize anesthesia choice clinical outcomes all US patients undergoing elective percutaneous transfemoral TAVR between April 1, 2014, June 30, 2015. Raw inverse probability treatment-weighted...
Health care workers (HCWs) caring for patients with coronavirus disease 2019 (COVID-19) are at risk of exposure to severe acute respiratory syndrome 2 (SARS-CoV-2). Currently, our knowledge, there is no effective pharmacologic prophylaxis individuals risk.To evaluate the efficacy hydroxychloroquine prevent transmission SARS-CoV-2 in hospital-based HCWs COVID-19 using a pre-exposure strategy.This randomized, double-blind, placebo-controlled clinical trial (the Prevention and Treatment With...
Mice lacking leukocyte type 12/15-lipoxygenase (12/15-LO) show reduced atherosclerosis in several models. 12/15-LO is expressed a variety of cells, including vascular adipocytes, macrophages, and cardiomyocytes. The purpose this study was to determine which cellular source important for atherosclerosis.Bone marrow from 12/15-LO-/-/apoE-/- mice transplanted into apoE-/- vice versa. Deficiency bone cells protected fed Western diet the same extent as complete absence 12/15-LO, although plasma...
Background Observational studies have identified height as a strong risk factor for atrial fibrillation, but this finding may be limited by residual confounding. We aimed to examine genetic variation in within the Mendelian randomization (MR) framework determine whether has causal effect on of fibrillation. Methods and findings In summary-level analyses, MR was performed using summary statistics from genome-wide association (GIANT/UK Biobank; 693,529 individuals) fibrillation (AFGen; 65,446...
Leukocyte and platelet accumulation at sites of cerebral ischemia exacerbate damage. The ectoenzyme CD39 on the plasmalemma endothelial cells metabolizes ADP to suppress in ischemic brain. However, role leukocyte surface regulating monocyte neutrophil trafficking this setting is not known. Here we have demonstrated mice what believe be a novel mechanism by which monocytes neutrophils regulates their own sequestration into tissue, catabolizing nucleotides released injured cells, thereby...
Autonomic neuromodulation provides therapeutic benefit in ventricular tachycardia (VT) storm. Transcutaneous magnetic stimulation (TcMS) can noninvasively and nondestructively modulate a patient's nervous system activity may reduce VT burden patients with storm.To evaluate the safety efficacy of TcMS left stellate ganglion for storm.This double-blind, sham-controlled randomized clinical trial took place at single tertiary referral center between August 2019 July 2021. The study included 26...
Hypoxia, as occurs during tissue ischemia, tips the natural anticoagulant/procoagulant balance of endovascular wall to favor activation coagulation.Plasminogen activator inhibitor-1 (PAI-1) is an important factor suppressing fibrinolysis under conditions low oxygen tension.We previously reported that hypoxia induced PAI-1 mRNA and antigen expression in murine macrophages secondary increased de novo transcription well stability.We now show RAW264.7 factors early growth response gene-1...
CD39 is a transmembrane enzyme that inhibits platelet reactivity and inflammation by phosphohydrolyzing ATP ADP to AMP. Cyclic AMP (cAMP), an essential second messenger, particularly important in regulating genes controlling vascular homeostasis. These experiments test the hypothesis cAMP might positively regulate expression of thereby modulate homeostatic properties. Cd39 mRNA was induced 13.8- fold RAW cells treated with membrane-permeant analogue (8-bromo-cyclic AMP; 8-Br-cAMP),...
Abstract Ectoenzymes expressed on the surface of vascular cells and leukocytes modulate ambient nucleotide milieu. CD73 is an ecto-5′ nucleotidase that catalyzes terminal phosphohydrolysis AMP resides in brain glial cells, choroid plexus, leukocytes. Though tightens epithelial barriers, its role ischemic remains undefined. When subjected to photothrombotic arterial occlusion, CD73−/− mice exhibited significantly larger (49%) cerebral infarct volumes than wild-type mice, with concordant...
The ability of cells to detect and respond nucleotide signals in the local microenvironment is essential for vascular homeostasis. enzyme ectonucleotide tri(di)phosphohydrolase-1 (ENTPD1, also known as CD39) on surface leukocytes endothelial metabolizes locally released, intravascular ATP ADP, thereby eliminating these prothrombotic proinflammatory stimuli. Here, we evaluated contribution CD39 atherogenesis apolipoprotein E–deficient (ApoE-deficient) mouse model atherosclerosis. Compared...