A5079303751- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Tracheal and airway disorders
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Heat shock proteins research
- Sleep and Wakefulness Research
- Atmospheric chemistry and aerosols
- Immune Cell Function and Interaction
- Sleep and related disorders
- Toxin Mechanisms and Immunotoxins
- thermodynamics and calorimetric analyses
- Cell Adhesion Molecules Research
- Air Quality and Health Impacts
- Drug Transport and Resistance Mechanisms
- Insect and Pesticide Research
- Glycosylation and Glycoproteins Research
- Genomics and Rare Diseases
- Catalytic Processes in Materials Science
- Neonatal Respiratory Health Research
- Dietary Effects on Health
- Signaling Pathways in Disease
- Air Quality Monitoring and Forecasting
- Gene Regulatory Network Analysis
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati Medical Center
2017-2025
Circadian (United States)
2021-2025
Harvard University
1966-2024
Temple University
2024
University of Cincinnati
2017-2024
Sabin Vaccine Institute
2018-2024
American Academy of Otolaryngology — Head and Neck Surgery
2024
George Washington University
1963-2022
University of Liverpool
2003-2021
P-selectin (CD62, GMP-140, PADGEM), a Ca(2+)-dependent lectin on activated platelets and endothelium, functions as receptor for myeloid cells by interacting with sialylated, fucosylated lactosaminoglycans. binds to limited number of protease-sensitive sites cells, but the protein(s) that carry glycans recognized are unknown. Blotting neutrophil or HL-60 cell membrane extracts [125I]P-selectin affinity chromatography [3H]glucosamine-labeled were used identify ligands. A major ligand was...
A laboratory intercomparison of organic carbon (OC) and elemental (EC) measurements atmospheric particulate matter samples collected on quartz filters was conducted among eight participants the ACE-Asia field experiment. The took place in two stages: first round when filter during experiment were being analyzed for OC EC, second after included selected from Each participant operated ECOC analyzers same manufacturer utilized analysis protocol their measurements. precision fiber a function...
We assessed the frequency, causes and consequences of erroneous diagnosis epilepsy, outcome patients referred with `refractory epilepsy', by retrospective analysis case records 324 patients. The sample was divided into those exposed to anti-epileptic drugs (n=184), whom 92 were said have refractory seizures, who had not received treatment (n=140). latter group is reported elsewhere. overall misdiagnosis rate 26.1% (46/184), incomplete history-taking misinterpretation EEG equally responsible....
Bioinformatic analyses of human tissue samples were used to build a database rhythmically expressed genes across the body.
High-risk human papillomavirus (HPV) is an established cause of head and neck carcinomas arising in the oropharynx. The presence HPV has also been reported some sinonasal tract, but little known about their overall incidence or clinicopathologic profile. surgical pathology archives Johns Hopkins Hospital were searched for all tract from 1995 to 2011, tissue microarrays constructed. p16 immunohistochemical analysis DNA situ hybridization high-risk types performed. Demographic clinical outcome...
Circadian precision medicine may supplement genetic to improve drug action
Summary: The need for new antiepileptic drugs (AEDs) and more sensitive methods of assessing their efficacy is well recognized. This study was designed to evaluate the safety lamotrigine (LTG), a potential AED develop test outcome measures. A health‐related quality life (HRQL) model developed which contains previously validated measures anxiety, depression, happiness, overall mood, self‐esteem, mastery specifically seizure severity scale with patient‐ caregiver‐based components. HRQL used in...
Hop, an abundant and conserved protein of unresolved function, binds concomitantly with heat shock 70 (Hsp70) Hsp90, participates proteins at intermediate stage progesterone receptor assembly, is required for efficient assembly mature complexes in vitro. A largely untested hypothesis that Hop functions as adaptor targets Hsp90- to Hsp70-substrate complexes; if true, then loss either Hsp70 binding or Hsp90 by should equally disrupt its ability promote complexes. To generate mutants...
Molecular chaperones mediate multiple aspects of steroid receptor function, but the physiological importance most receptor-associated cochaperones has not been determined. To help fill this gap, we targeted for disruption mouse gene 52-kDa FK506 binding protein, FKBP52, a 90-kDa heat shock protein (Hsp90)-binding immunophilin found in complexes. A line lacking FKBP52 (52KO) was generated and characterized. Male 52KO mice have several defects reproductive tissues consistent with androgen...
Mice lacking leukocyte type 12/15-lipoxygenase (12/15-LO) show reduced atherosclerosis in several models. 12/15-LO is expressed a variety of cells, including vascular adipocytes, macrophages, and cardiomyocytes. The purpose this study was to determine which cellular source important for atherosclerosis.Bone marrow from 12/15-LO-/-/apoE-/- mice transplanted into apoE-/- vice versa. Deficiency bone cells protected fed Western diet the same extent as complete absence 12/15-LO, although plasma...
Granule membrane protein-140 (GMP-140) is an inducible receptor for myeloid leukocytes on activated platelets and endothelium. Like other selectins, GMP-140 recognizes specific oligosaccharide ligands. However, prior data the nature of these ligands are contradictory. We investigated structural features required ligand interaction with using purified GMP-140, cells naturally expressing oligosaccharides, cloned glycosyltransferases. related selectin endothelial leukocyte adhesion molecule-1...
Significance Circadian clocks are present in most cells of the body and act concert to coordinate our daily physiology behavior with environment. misalignment between environment has been implicated various pathologies. Here, we show that circadian can also occur different peripheral tissues following exposure hypoxia it stems from differential response core clock components hypoxia. Intertissue occurs upon intermittent hypoxia, a model for obstructive sleep apnea (OSA). Our findings...
Skin is the largest organ in body and serves important barrier, regulatory, sensory functions. The epidermal layer shows rhythmic physiological responses to daily environmental variation (e.g., DNA repair). We investigated role of circadian clock transcriptional regulation epidermis using a hybrid experimental design, which limited set human subjects (n = 20) were sampled throughout 24-h cycle larger population 219) once. found robust oscillator at level pairwise correlations...