A5062729823- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Thermal Regulation in Medicine
- Cardiac Ischemia and Reperfusion
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
- Ultrasound and Hyperthermia Applications
- Cardiomyopathy and Myosin Studies
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Medical Imaging Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Aortic Thrombus and Embolism
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Transplantation: Methods and Outcomes
Lund University
2013-2025
Skåne University Hospital
2010-2025
ASL Roma
2024
Centre Cardiologique du Nord
2024
Hospital Clínico San Carlos
2024
Hôpital Maison Blanche
2024
St. Eugenio Hospital
2024
University Hospital of Basel
2024
Umeå University
2023
Johns Hopkins University
2017
Background— Experimental studies have shown that induction of hypothermia before reperfusion acute coronary occlusion reduces infarct size. Previous clinical studies, however, not been able to show this effect, which is believed be mainly because therapeutic temperature was reached in the majority patients. We aimed evaluate safety and feasibility rapidly induced by infusion cold saline endovascular cooling catheter patients with myocardial infarction. Methods Results— Twenty infarction...
Abstract Background The aim of this study was to evaluate the combination a rapid intravenous infusion cold saline and endovascular hypothermia in closed chest pig infarct model. Methods Pigs were randomized pre-reperfusion (n = 7), post-reperfusion 7) or normothermia 5). A percutaneous coronary intervention balloon inflated left anterior descending artery for 40 min. Hypothermia started after 25 min ischemia immediately reperfusion by 1000 ml 4°C hypothermia. Area at risk evaluated vivo...
The aim of this study was to evaluate the prevalence triple antithrombotic therapy (TT) (warfarin, aspirin and clopidogrel) in patients following an acute coronary syndrome (ACS), bleeding risk compared double antiplatelet (DAPT) (aspirin accuracy HAS-BLED score predicting serious events TT patients.We retrospectively identified all ACS on upon discharge from Coronary Care Unit at Skane University Hospital between 2005 2010. were age- sex-matched control discharged with DAPT. Major defined...
Early reperfusion in the setting of an ST-elevation myocardial infarction (STEMI) is utmost importance. However, effects early versus late this patient group undergoing primary percutaneous coronary intervention (PCI) have so far been inconsistent previous studies. The purpose study was to evaluate a nationwide cohort delay from first medical contact PCI (first [FMC]-to-PCI) and secondarily symptom-to-PCI on clinical outcomes.Using national Swedish Coronary Angiography Angioplasty Register...
This study aimed to investigate whether an overestimation of infarct size on cardiac magnetic resonance (CMR) versus triphenyltetrazolium chloride (TTC) exists acutely and it remains after 7 days in experimental pig model elucidate possible mechanisms. Overestimation (IS) late gadolinium enhancement CMR early acute myocardial infarction has been debated. Pigs were subjected 40 min left anterior descending artery occlusion 6 h (n = 9) or reperfusion. IS by vivo ex was compared with TTC...
Tissue-specific circulating micro-RNAs (miRNAs) are released into the blood after organ injury. In an ischemic porcine cardiogenic shock model, we investigated release pattern of cardiac-specific miR-208b and liver-specific miR-122 assessed effect therapeutic hypothermia on their respective plasma levels. Pigs were anesthetized, was induced by inflation a percutaneous coronary intervention balloon in proximal left anterior descending artery for 40 min followed reperfusion. After fulfillment...
Late gadolinium enhancement (LGE) border zone on cardiac magnetic resonance imaging has been proposed as an independent predictor of ventricular arrhythmias. The purpose was to determine whether size and heterogeneity LGE predict appropriate implantable cardioverter defibrillator (ICD) therapy in ischemic cardiomyopathy (ICM) nonischemic (NICM) patients evaluate 4 border-zone algorithms.ICM NICM who underwent prior ICD implantation were retrospectively included. Two semiautomatic algorithms,...
Abstract Background Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has shown to inhibit related neutrophil activation. shields neutrophils from activation before they enter reperfused area, which could be mechanistic advantage compared previous directed reperfusion therapies. We investigated if treatment with ADC-1004, according clinically...
Dual antiplatelet therapy (DAPT) reduces ischemic events but increases bleeding risk, especially in patients with high risk (HBR). This study aimed to compare outcomes of abbreviated versus standard DAPT strategies HBR acute coronary syndrome undergoing percutaneous intervention.
Abstract Background In experimentally induced myocardial infarction, mild hypothermia (33–35°C) is beneficial if applied prior to ischemia or reperfusion. Hypothermia, when after reperfusion seems confer little no benefit. The mechanism by which exerts its cell-protective effect during cardiac remains unclear. It has been hypothesized that reduces the damage; additional damage incurred upon myocardium Reperfusion results in a massive increase blood flow, reactive hyperemia, may contribute...
Abstract Background Ectonucleotidase dependent adenosine generation has been implicated in preconditioning related cardioprotection against ischemia-reperfusion injury, and treatment with a soluble ectonucleotidase shown to reduce myocardial infarct size (IS) when applied prior induction of ischemia. However, according clinically applicable protocol, administration only after ischemia, not previously evaluated. We therefore investigated if the apyrase, would IS microvascular obstruction (MO)...
AimsDetermination of the myocardium at risk (MaR) and final infarct size by cardiac magnetic resonance imaging (CMR) enables calculation salvaged in acute infarction. T2-weighted is performed prior to administration gadolinium, since gadolinium affects T2 tissue properties. This is, however, difficult an ex vivo model must be administered for determination CMR. We aimed test ability assess MaR using myocardial perfusion single photon emission computed tomography (SPECT) as reference...
Repolarization indices of ECG have been widely assessed as predictors ventricular arrhythmias. However, little is known the dynamic changes these parameters during continuous monitoring in acute ischaemic episodes. The objective study was to evaluate repolarization-related fibrillation (VF) progression experimental myocardial infarction.Myocardial infarction induced 27 pigs by 40-min balloon inflation left anterior descending coronary artery, and 12-lead continuously recorded. Rate-corrected...
AimsCardiovascular magnetic resonance (CMR) imaging can measure the myocardial area at risk (AAR), but technique has received criticism for inadequate validation. CMR commonly depicts an AAR that is wider than infarct, which in turn would require a lateral perfusion gradient within AAR. We investigated presence of and validated measures against three independent reference standards high quality.
Cardiovascular magnetic resonance (CMR) can accurately measure left ventricular (LV) mass, and several measures related to LV wall thickness exist. We hypothesized that prognosis be used select an optimal of for characterizing hypertrophy. Subjects having undergone CMR were studied (cardiac patients, n = 2543; healthy volunteers, 100). A new measure, global (GT, GTI if indexed body surface area) was calculated from mass end-diastolic volume. Among patients with follow-up (n 1575, median 5.4...