A5082513643- Galectins and Cancer Biology
- Cardiomyopathy and Myosin Studies
- Macrophage Migration Inhibitory Factor
- Peptidase Inhibition and Analysis
- Atrial Fibrillation Management and Outcomes
- Receptor Mechanisms and Signaling
- Genetic Neurodegenerative Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Hormonal Regulation and Hypertension
- Cardiac Structural Anomalies and Repair
- Cancer Mechanisms and Therapy
- Cardiovascular Effects of Exercise
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- IL-33, ST2, and ILC Pathways
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Platelet Disorders and Treatments
- Thermoregulation and physiological responses
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Cardiovascular Issues in Pregnancy
- RNA modifications and cancer
Vanderbilt University Medical Center
2019-2025
Shenzhen University
2024
Baker Heart and Diabetes Institute
2010-2019
The Heart Research Institute
2007-2008
Clonal hematopoiesis of indeterminate potential (CHIP) occurs due to acquired mutations in bone marrow progenitor cells. CHIP confers a 2-fold risk atherosclerotic cardiovascular disease. However, there are limited data regarding specific phenotypes. The purpose this study was define the coronary artery disease phenotype population-based on angiography.
Background Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers cardiac remodeling, their ability to improve prediction when added a clinical model. Methods Results Blood samples collected before de novo catheter were analyzed. Levels bone morphogenetic protein‐10, angiopoietin‐2, fibroblast growth factor‐23, insulin‐like factor‐binding protein‐7, myosin‐binding protein C3, differentiation factor‐15,...
The Polycomb-group protein, Ezh2, is required for epigenetic gene silencing in the adult heart by unknown mechanism. We investigated role of Ezh2 and non-coding RNAs a mouse model pressure overload using transverse aortic constriction (TAC) attenuated prototypical histone deacetylase inhibitor, trichostatin A (TSA). Chromatin immunoprecipitation TAC TAC+TSA hearts suggests interaction primary microRNA-208b (pri-miR-208b) regulation hypertrophic expression. RNAi pri-miR-208b validate...
Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether well-accepted murine model of HFpEF also displays features PH, we identify pathways that might drive early remodeling the pulmonary vasculature HFpEF.
Background: The EARLY TAVR trial demonstrated that early transcatheter aortic valve replacement (TAVR) intervention was superior to clinical surveillance (CS) with delayed in patients asymptomatic, severe stenosis (AS). Cardiac biomarkers are associated maladaptive remodeling, symptom onset, and worse outcomes after TAVR. Whether elevated identify asymptomatic more likely benefit from is unknown. Methods: A core laboratory measured N-terminal pro-B-type natriuretic peptide (NT-proBNP) high...
The role of beta-adrenoceptors in heart disease remains controversial. Although beta-blockers ameliorate the progression disease, mechanism undefined. We investigated effect on cardiac hypertrophic growth using beta(1)- and beta(2)-adrenoreceptor knockout wild-type (WT) mice.Mice were subjected to aortic banding or sham surgery, their function was determined by echocardiography micromanometry.At 4 12 weeks after banding, left ventricle:body mass ratio increased 80-87% mice, but only 15%...