A5065812198- Pregnancy-related medical research
- Pelvic and Acetabular Injuries
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Vasculitis and related conditions
- Occupational Health and Performance
- Pituitary Gland Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Adrenal and Paraganglionic Tumors
- Reproductive System and Pregnancy
- Maternal and Perinatal Health Interventions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antibiotic Resistance in Bacteria
- Birth, Development, and Health
- Oral microbiology and periodontitis research
- Uterine Myomas and Treatments
- Global Public Health Policies and Epidemiology
- Bacterial biofilms and quorum sensing
- Injury Epidemiology and Prevention
- Health and Medical Research Impacts
- Endometriosis Research and Treatment
- Cardiovascular Issues in Pregnancy
- Thyroid Cancer Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Hormonal Regulation and Hypertension
Act Health
2024
Australian National University
2016-2023
Canberra Hospital
2018-2023
ACT Government
2023
The University of Melbourne
2004-2018
The University of Adelaide
2015-2017
Basil Hetzel Institute
2017
University of Florida
2011-2012
Florida College
2011-2012
University of Pittsburgh
2006-2011
The peptide hormone relaxin is a potent vasodilator with therapeutic potential in diseases complicated by vasoconstriction, including heart failure. However, the molecular mediators and magnitude of vasodilation may vary according to duration exposure artery type. objective these studies was determine mechanisms rapid (within minutes) relaxin-induced examine whether dilates arteries from different animal species vascular beds. Rat mouse small renal, rat mesenteric, human sc were isolated,...
Many infectious diseases are associated with multidrug-resistant (MDR) bacteria residing in biofilms that require high antibiotic concentrations. While oral drug delivery is frequently ineffective, topical treatments have the potential to deliver higher concentrations infection site while reducing systemic side effects. This study determined antibiofilm activity of a surgical wound gel loaded iron chelator deferiprone (Def) and heme analogue gallium-protoporphyrin (GaPP), alone combination...
Relaxin is emerging as an important vasodilator of pregnancy and being tested for afterload reduction in acute heart failure. However, the mechanisms underlying relaxin-induced vasodilation are incompletely understood. The aims this study were to establish a new vitro model use approach, well chronically instrumented, conscious rats, investigate role angiogenic growth factors relaxin vasodilatory pathway. Incubation rat mouse small renal arteries with recombinant human H2 3 hours attenuated...
Vascular gelatinase activity is essential for pregnancy- and relaxin (Rlx)-induced renal vasodilation hyperfiltration in rats. The objective of this study was to further elucidate the mechanisms increase vascular matrix metalloproteinase (MMP)-2 caused by pregnancy Rlx. We first corroborated our earlier work showing that pro- active forms MMP-2 were increased small arteries from pregnant compared with virgin rats Rlx-treated vehicle-treated nonpregnant next investigated other artery types...
Administration of recombinant human relaxin (rhRLX) to conscious rats increases global arterial compliance, and small renal arteries (SRA) isolated from these demonstrate increased passive compliance. Here we characterize relaxin-induced vascular remodeling examine its functional relevance. SRA external iliac (EIA) were examined in rhRLX-treated (1.0 μg/h for 5 days) knockout mice. Arterial geometric compositional quantified using immunohistochemical biochemical techniques. Vascular...
The major functions of relaxin (RLX) are associated with female reproductive tract physiology, namely, the regulation biochemical processes involved in remodeling extracellular matrix components cervix and vagina at term. Studies RLX-deficient mice (Rlx-/-) demonstrate that although females give birth to live young without apparent dystocia, pubic symphysis is not elongated, they have abnormal cervical vaginal morphology. current study examined phenotypic differences collagen,...
Early-term delivery is an important cause of short-term neonatal morbidity and associated high healthcare costs, with possible additional long-term developmental ramifications. As a form 'iatrogenic' delivery, induction labour (IOL) potentially modifiable contributor to this burden.To determine patterns of, primary indication for, early-term IOL, as well temporal trends in differences from other modes respect maternal factors maternal/neonatal outcomes.The Canberra Hospital births database...
The factors that predispose one-tenth of reproductive-aged women to endometriosis are poorly understood. We determined genetic deficiency in transforming growth factor β1 impairs endometriosis-like lesion mice. Given seminal plasma is an abundant source β, we evaluated the effect exposure on endometrial lesions. Human explants were exposed or control medium before transfer Prkdcscid-mutant (severe combined immunodeficient) Xenografts showed eightfold increase volume and a 4.3-fold weight...
We report a case of biopsy-proven cutaneous leukocytoclastic vasculitis developing 10 days after starting verapamil and atorvastatin in patient with long-standing Sjogren's syndrome. This highlights the need to monitor for this rare adverse effect.
The peptide hormone relaxin is expressed in the prostate gland and secreted into seminal plasma; however, its function within has not been established. Relaxin-mutant mice (Rln(-/-)) were reported to have abnormal morphology, but there was no phenotype receptor-mutant (Rxfp1(-/-)) mice. present study aimed verify phenotypes anterior, dorsal lateral lobes of Rln(-/-) Rxfp1(-/-) at different adult ages. also treated with evaluate effects exogenously administered on morphology. Comparisons...
Relaxin regulates cervical extracellular matrix (ECM) remodelling during pregnancy by modifying collagen and other ECM molecules unknown mechanisms. We hypothesised that abnormal in the cervix of pregnant relaxin-deficient (Rln1−/−) mice is due to excessive (Col1a1 Col3a1) decreased metalloproteinases (Mmp2, Mmp9, Mmp13 Mmp7) oestrogen receptors (Esr1 Esr2). Quantitative polymerase chain reaction, gelatinase zymography, MMP activity assays histological staining evaluated changes wildtype...
Hypertension in young patients can mask rare conditions like paragangliomas, especially the absence of conventional symptoms. A comprehensive diagnostic evaluation and multidisciplinary approach are crucial for optimal management outcomes.
IntroductionVasculitis is an inflammatory disease with variable end-organ damage that classified based on involvement of small, medium or large vessels.1 Leukocytoclastic vasculitis a small-vessel predominantly affecting dermal capillaries and venules, often secondary to underlying systemic vasculitis, infection drug exposure.1 Commonly implicated drugs include beta-lactam antibiotics non-steroidal anti-inflammatory drugs,1 while calcium channel blockers hydroxymethylglutaryl-coA reductase...
The peptide hormone relaxin (RLX) is reported to directly affect uterine oestrogen receptors (ERs) in the rat (1). Treatment of immature ovariectomised rats with porcine RLX causes a decrease ERβ mRNA levels within 6 h. However, has no effect on ERα expression. As both ERβ1 and ERβ2 inhibit ER-mediated transcriptional activity, this RLX-induced downregulation could be prerequisite for exert its effects target tissues. aim current study was use relaxin-deficient (Rlx–/–) pregnant mice...
The major functions of relaxin are associated with female reproductive physiology, especially the regulation biochemical processes involved in remodelling tract at term. Studies deficient mice (Rlx–/–) demonstrate that although females give birth to live young without apparent dystocia, they have abnormal cervices and vaginae. This phenotype is attributed an increase stromal collagen, but mechanism(s) by which regulates extracellular matrix (ECM) production tissues poorly understood. In this...