Background— Ca 2+ leak from the sarcoplasmic reticulum (SR) may play an important role in triggering and/or maintaining atrial arrhythmias, including fibrillation (AF). Protein kinase A (PKA) hyperphosphorylation of cardiac ryanodine receptor (RyR2) resulting dissociation channel-stabilizing subunit calstabin2 (FK506-binding protein or FKBP12.6) causes SR failing hearts and can trigger fatal ventricular arrhythmias. Little is known about RyR2 dysfunction AF, however. Methods Results— Left...

The purpose of this study is to develop a hierarchy-based model for supply chain resilience (SCRES), explaining the dynamics between various enablers and validating empirically. Literature review survey identified enablers. Interpretive structural modelling (ISM) used analyse levels relationships among Based on their driving power dependence, these are also classified into different categories. Structural equation validate hierarchical SCRES test path analytical model. provides empirical...

Supply chain management is a major issue in many industries as firms realize the importance of creating an integrated relationship with their suppliers and customers. Managing supply has become way improving competitiveness by reducing uncertainty enhancing customer service. This paper analyzes various issues important to provides broader awareness principles concepts. The role planning coordination complex systems information technology synchronize described framework that creates...

Purpose Cloud-based enterprise resource planning (ERP) enables an organization to pay for the services they need and removes maintain information technology infrastructure. The purpose of this paper is empirically test role cloud-based ERP on performance organization. Here, categorized as supply chain organizational that comprises financial marketing performance. Contingent resource-based view (RBV) theory was used develop a theoretical framework in which base complexity (SBC) acts...

Abstract The concept of supply chain is about managing coordinated information and material flows, plant operations, logistics. It provides flexibility agility in responding to consumer demand shifts without cost overlays resource utilization. fundamental premise this philosophy is; synchronization among multiple autonomous business entities represented it. That is, improved coordination within between various supply‐chain members. Increased can lead reduction times costs, alignment...

Although the incidence of atrial fibrillation (AF) increases with age, cellular electrophysiological changes that render atria aged individuals more susceptible to AF remain poorly understood. We hypothesized dispersion repolarization aging, creating a substrate for initiation AF.Four groups dogs were studied: adult and old in normal sinus rhythm (SR) chronic (CAF) induced by rapid pacing. In each dog, action potentials (AP) recorded microelectrodes from isolated endocardial preparations...

The purpose of this paper is to develop a business model generate quantitative evidence the benefits implementing radio frequency identification (RFID) technology, limiting scope outpatient surgical processes in hospitals.The study primarily uses define-measure-analyze-improve-control (DMAIC) approach, and draws on various analytical tools such as work flow diagrams, value stream mapping, discrete event simulation examine effect RFID technology improving effectiveness (quality timeliness)...

Influenza and COVID-19 are infectious diseases with significant burdens. Information awareness on preventative techniques can be spread through the use of social media, which has become an increasingly utilized tool in recent years. This study developed a dynamic transmission model to investigate impact particularly tweets via networking platform, Twitter number influenza cases infection deaths. We modified traditional Susceptible-Exposed-Infectious-Recovered (SEIR-V) additional media...

Background— We tested the hypothesis that I Ca,L is important to development of cardiac memory. Methods and Results— The effects L-type Ca 2+ channel blockade β-blockade were on acutely anesthetized chronically instrumented, conscious dogs. Short-term memory (STM) was induced by 2 hours ventricular pacing long-term (LTM) for 21 days. STM dogs received placebo, nifedipine, or propranolol, LTM atenolol, amlodipine. AT 1 receptor (candesartan) ACE inhibition (trandolapril) also in LTM....

Non-pharmaceutical intervention (NPI) policies, ranging from mild measures to total isolation, were implemented worldwide during the COVID-19 pandemic. We adopt a systematic approach guide policymakers in deploying NPI policies mitigate pandemic's effects while balancing their social and economic impacts. Our results show that each has an optimal duration, beyond which its effectiveness plateaus. Stricter require longer durations, when sustained for period, earlier implementation is more...

Abstract Information sharing is a key enabler for supply chain management. The type of information required depends upon the problem to be solved. In this paper, taxonomy proposed as theoretical basis designing problem-solving. Problem provides overall framework under which problem-oriented system components can designed, and implemented. Supply comprises: (a) classification problems, (b) solving methodologies management, (c) hierarchical variables or factors necessary dealing with problems....

Purpose – Many studies have proposed variant fuzzy time series models for uncertain and vague data. The purpose of this paper is to adapt a combined with genetic algorithm (GA) forecast tourist arrivals in Taiwan. Design/methodology/approach Different cases are studied understand the effect variation order, number intervals population size on fitness function which decreases increase order intervals, but do not marginal due change size. Findings Results based an example forecasting Taiwan’s...

Purpose Large supply and computer networks contain heterogeneous information correlation among their components, are distributed across a large geographical region. This paper aims to investigate develop generic knowledge integration framework that can handle the challenges posed in complex network management. It also seeks examine this various applications of essential management tasks different infrastructures. Design/methodology/approach Efficient technologies key capably handling...