A5028558271- Customer Service Quality and Loyalty
- Consumer Behavior in Brand Consumption and Identification
- Digital Marketing and Social Media
- Cardiovascular Effects of Exercise
- Psychology of Social Influence
- Consumer Retail Behavior Studies
- Developmental Biology and Gene Regulation
- Sports injuries and prevention
- Technology Adoption and User Behaviour
- Cardiac Arrhythmias and Treatments
- Sharing Economy and Platforms
- Cardiac electrophysiology and arrhythmias
- HIV/AIDS drug development and treatment
- Environmental Sustainability in Business
- HIV Research and Treatment
- International Relations in Latin America
- Metallic Glasses and Amorphous Alloys
- Biochemical and Molecular Research
- Neurobiology and Insect Physiology Research
- French Urban and Social Studies
- Service and Product Innovation
- Post-Communist Economic and Political Transition
- Health Systems, Economic Evaluations, Quality of Life
- Business Strategy and Innovation
- Global Trade and Competitiveness
Université de Bourgogne
2017-2024
Université de Haute-Alsace
2008-2024
Université de Strasbourg
2013-2023
Centre d'Etudes et de Recherches Appliquées à la Gestion
2018-2022
Centre de REcherche En Gestion des Organisations
2018-2022
Nantes Université
2020-2022
Icahn School of Medicine at Mount Sinai
2017-2022
Institut de Transplantation Urologie en Nephrologie
2021-2022
Inserm
2012-2022
Center for Research in Transplantation and Translational Immunology
2021-2022
AimsFive desmosomal genes have been recently implicated in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) but the clinical impact of genetics remains poorly understood. We wanted to address potential genotyping.
Over the past decade, corporate philanthropy has undergone two fundamental transformations – strategic refocusing and globalization. Faced with scarcer resources downsizing, leading firms have redefined by tying it directly to strategies business units. Philanthropy is now seen as a component of long‐term competitiveness, rather than short‐term image builder sales generator. Internationally can not only enhance unify global image, but also help open emerging markets through much‐needed...
The 3′-processing of the extremities viral DNA is first two reactions catalyzed by HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete integration, but it remains unclear which oligomer responsible reaction. Moreover, tends to aggregate, and unknown whether polymerization or aggregation this enzyme on detrimental beneficial activity. We have developed a fluorescence assay based anisotropy monitoring release terminal dinucleotide product in real-time. Because...
Risk-sharing agreements, under which payers and pharmaceutical manufacturers agree to link payment for drugs health outcomes achieved, rather than the volume of products used, offer an appealing model pharmaceuticals. Although such agreements have been widely touted, experience date mainly demonstrates how hard they are implement. Barriers include high implementation costs, measurement challenges, absence a suitable data infrastructure. arrangements could gain traction in United States as...
ABSTRACT Integrase (IN), the HIV-1 enzyme responsible for integration of viral genome into chromosomes infected cells, is target recently approved antiviral raltegravir (RAL). Despite this drug's activity against viruses resistant to other antiretrovirals, failures therapy were observed, in association with emergence resistance due mutations integrase coding region. Two pathways involving primary on residues N155 and Q148 have been characterized. It was suggested that at residue Y143 might...
In the Drosophila bristle lineage, five differentiated cells arise from a precursor cell after rapid sequence of asymmetric divisions (one every 2 hours). We show that, in mitotic cells, this cadence is associated with cycles essentially devoid G1-phase. This feature due to expression Cyclin E that precedes each division, and differential S-transition negative regulator, Dacapo. Thus, apart endocycles (G/S), which occurred two out terminal other coexist lineage: (1) an atypical cycle...
STUDY/PRINCIPLES: Arrythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an autosomal-dominantly inherited disease caused by mutations in genes encoding desmosomal proteins and characterised fibrofatty replacement occurring predominantly the ventricle can result sudden cardiac death. Naxos Carvajal syndrome, autosomal recessive forms of ARVC/D, are involvement and/or left association with palmoplantar keratoderma woolly hair. The aim present study has been to screen for protein...
HIV-1 integrase catalyzes the insertion of viral genome into chromosomal DNA. We characterized structural determinants 3′-processing reaction specificity—the first integration process—at DNA-binding level. found that N-terminal domain, containing a pseudo zinc-finger motif, plays key role, at least indirectly, in formation specific integrase–DNA contacts. This motif mediates cooperative DNA binding occurs only with cognate/viral sequence and physiologically relevant Mg2+ cofactor. The was...
ORIGINAL RESEARCH article Front. Physiol., 27 December 2012Sec. Cardiac Electrophysiology Volume 3 - 2012 | https://doi.org/10.3389/fphys.2012.00474
Understanding the mechanisms that coordinate cell proliferation, cycle arrest, and differentiation is essential to address problem of how "normal" versus pathological developmental processes take place. In bristle lineage adult fly, we have tested capacity post-mitotic cells re-enter in response overexpression cyclin E. We show only terminal which identity independent Notch pathway undergo extra divisions after CycE overexpression. Our analysis shows responsiveness forced proliferation...
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is an inherited cardiomyopathy characterized by fibro-fatty replacement of the ventricle and arrhythmias. The major disease-causing genes encode cardiac desmosomal components but are involved in only ∼50% patients. To identify missing genetic determinants, we used a candidate gene approach, focusing on 3′-untranslated region (UTR) main ARVC/D PKP2 additional structure or function. We screened population 64 probands with no...
<h3>Background</h3> Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease in which mutations affecting <i>Plakophilin-2</i> (<i>PKP2</i>) are the most frequently detected. However, pathogenicity of variants not always fully determined. <i>PKP2</i> encodes two isoforms, longest (PKP2b) includes alternatively spliced exon 6, routinely screened for molecular diagnosis, despite absence data on cardiac expression PKP2 isoforms. <h3>Objective</h3> To examine 6 by...