A5064966548- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Cardiovascular and Diving-Related Complications
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Surgical Sutures and Adhesives
- Hemostasis and retained surgical items
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Pulmonary Hypertension Research and Treatments
- Polymer Surface Interaction Studies
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Soft Robotics and Applications
- Cardiovascular Conditions and Treatments
- Adhesion, Friction, and Surface Interactions
- Diversity and Career in Medicine
- RNA modifications and cancer
- Congenital heart defects research
- Second Language Learning and Teaching
Universität Hamburg
2023-2025
University Medical Center Hamburg-Eppendorf
2023-2025
Boston Children's Hospital
2011-2024
Harvard University
2011-2024
Boston University
2023
Eppendorf (Germany)
2022
Kinderkrebs-Zentrum Hamburg
2022
Deutsches Herzzentrum München
2015-2021
Boston Children's Museum
2012-2021
Technical University of Munich
2019-2021
A light-activated, biodegradable adhesive seals cardiovascular defects in the presence of blood flow and could be useful during minimally invasive surgery.
Biodegradable elastomers synthesized under mild conditions with highly tunable mechanical properties are described. These elastomeric biomaterials biocompatible, exhibit minimal deformation following cyclical tensile loading, and permit tight control over the release kinetics of encapsulated bioactive molecules. As a service to our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized for online delivery, but not...
Achieving superior outcomes through the use of robots in medical applications requires an integrated approach to design robot, tooling and procedure itself. In this paper, is applied develop a robotic technique for closing abnormal communication between atria heart. The goal achieve efficacy surgical closure as performed on stopped, open heart with reduced risk trauma beating-heart catheter-based procedure. proposed approach, concentric tube robot used percutaneously access right atrium...
Abstract. Purpose: To determine whether different complement factor H (CFH) genotypes play a role in treatment of age‐related macular degeneration (AMD) with intravitreal bevacizumab. Methods: In this prospective study, we included 197 patients exudative AMD and treated 1.25 mg bevacizumab at 6‐week intervals until choroidal neovascularization (CNV) was no longer active. all patients, ophthalmological examinations, visual acuity, optical coherence tomography (OCT), fundus photography...
Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left syndrome (HLHS) is the most common and severe manifestation within spectrum of ventricular outflow tract obstruction defects occurring association with hypoplasia. The pathogenesis HLHS unknown, but hemodynamic disturbances are assumed to play a prominent role. To identify perturbations gene controlling muscle lineage development HLHS, we performed whole-exome sequencing 87 parent-offspring...
Abstract Even though medical devices have improved a lot over the past decades, there are still issues regarding their anti‐biofouling properties and tribological performance, both aspects contribute to short‐ long‐term failure of these devices. Coating with biocompatible layer that reduces friction, wear, biofouling at same time would be promising strategy address issues. Inspired by adhesion mechanism employed mussels, here, dopamine is made use immobilize lubricious mucin macromolecules...
( N Engl J Med . 2024;391:1877–1889. doi:10.1056/NEJMoa2314768) The Australian Reproductive Genetic Carrier Screening Project (Mackenzie’s Mission) aimed to assess the feasibility and outcomes of offering reproductive genetic carrier screening (RGCS) more than 10,000 couples, focusing on identification pathogenic variants in genes associated with severe, childhood-onset conditions. study tested these couples (free charge) for at least 1281 genes, linked about 750 autosomal recessive or...
A catheter-based technology reflects light to activate a photocurable adhesive for minimally invasive, atraumatic tissue defect closure.
Current materials for closure of cardiac defects such as ventricular septal (VSDs) are associated with compliance mismatch and a chronic inflammatory response. Bacterial nanocellulose (BNC) is non-degradable biomaterial promising properties high mechanical strength, favourable elasticity negligible reaction. The aim this study was the evaluation BNC patch VSD investigation its in vivo biocompatibility pig model. Young's modulus tensile strength patches were determined before after blood...
Neonates with complex congenital heart disease and pulmonary overcirculation have been historically treated surgically. However, subcohorts may benefit from less invasive procedures. Data on transcatheter palliation are limited.
Minimally invasive operations and percutaneous interventions are well-accepted options in the treatment of congenital heart defects. However, may be associated with an increased risk due to limited vascular access or a very tortuous catheter course. In these cases, combining operative interventional approaches direct puncture great vessels facilitate implantation even large devices. Furthermore, some situations, cardiopulmonary bypass circulatory arrest can omitted when doing hybrid...
Beating-heart image-guided intracardiac interventions have been evolving rapidly. To extend the domain of catheter-based and transcardiac into reconstructive surgery, a new robotic tool delivery platform tissue approximation device developed. Initial results using these tools to perform patent foramen ovale closure are described.A comprising superelastic metal tubes provides capability delivering manipulating devices inside beating heart. A technology is also presented that uses metal-based...
The use of tissue adhesives for internal clinical applications is limited due to a lack materials that balance strong adhesion with biocompatibility. substrate topography explored reduce the volume highly reactive and toxic glue without compromising adhesive strength. Micro‐textured patches coated thin layer cyanoacrylate achieve similar levels employing large amounts adhesive, superior level achieved when coating applied non‐textured patch. In vivo studies demonstrate reduced inflammation...
Abstract Background : Patent ducti arteriosi (PDAs) are more frequent and larger at high altitude than sea level. A novel PDA closure device, the Nitocclud PDA‐R, is designed specifically for both large medium size PDAs. The initial clinical experience with a new nitinol‐based device in patients PDAs described. Methods PDA‐R self‐expandable, self‐centering, repositionable occluder made of one nitinol wire without use welding. It contains several polyester membranes, delivered central guide...
OBJECTIVES Although mitral valve repair is rarely required in neonates, this population considered to be at high risk for adverse outcomes. The aim of study was review the indications surgery, mechanisms, techniques, and mid-term outcomes neonatal repair. METHODS demographic, procedural outcome data were obtained all neonates who underwent from 2005 2012. primary endpoints included mortality, transplantation reoperation. RESULTS Twenty patients during period. Median age operation 11 days...
Congenital mitral valve disease (CMVD) presents major challenges in its medical and surgical management.
The objective of this study was to examine the feasibility a modified technique cesarean section in which uterine incision is sutured one layer and visceral parietal peritoneum are left open. Two hundred patients undergoing low segment were prospectively randomized (according patients' identity numbers) into two groups. first group had standard including continuous double closure addition peritoneum. second underwent procedure as described above. compared technique, resulted shorter...