A5036916455- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Nitric Oxide and Endothelin Effects
- Migraine and Headache Studies
- Moyamoya disease diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Cardiac tumors and thrombi
- Aortic Disease and Treatment Approaches
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Endoplasmic Reticulum Stress and Disease
- Geriatric Care and Nursing Homes
- Craniofacial Disorders and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Trauma Management and Diagnosis
- Vascular Malformations and Hemangiomas
- Spinal Fractures and Fixation Techniques
- Osteomyelitis and Bone Disorders Research
University of Alberta Hospital
2012-2024
Health Sciences Centre
2018-2024
University of Alberta
2009-2024
Ottawa Hospital
2024
University of Ottawa
2024
Fondation Ophtalmologique Adolphe de Rothschild
2024
Centre Hospitalier de l’Université de Montréal
2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
NoNO (Canada)
2020
Alberta Hospital Edmonton
2018
<h3>BACKGROUND AND PURPOSE:</h3> Flow-diverting stents, such as the PED, have emerged a novel means of treating complex intracranial aneurysms. This retrospective analysis initial Canadian experience provides insight into technical challenges, clinical and radiographic outcomes, complication rates after use flow-diverting stents for unruptured <h3>MATERIALS METHODS:</h3> Cases were compiled from 7 centers between July 2008 December 2010. Each center prospectively tracked their experience;...
<h3>BACKGROUND AND PURPOSE:</h3> The PED is a flow-diverting stent designed for the treatment of cerebral aneurysms. We report 4 cases delayed ipsilateral IPH following technically successful anterior circulation aneurysms with PED. <h3>MATERIALS METHODS:</h3> Clinical and imaging data from all patients undergoing aneurysm at 2 institutions were analyzed to assess incidence after <h3>RESULTS:</h3> A total 66 (47 circulation) underwent between January 2008 November 2010. Four experienced...
<h3>Background</h3> Unruptured intracranial aneurysms (UIAs) are increasingly diagnosed and commonly treated using endovascular treatment or microsurgical clipping. The safety efficacy of treatments have not been compared in a randomised trial. How to treat patients with UIAs suitable for both options remains unknown. <h3>Methods</h3> We randomly allocated clipping coiling one more 3–25 mm judged treatable ways. primary outcome was failure, defined as: initial failure aneurysm treatment,...
<h3>BACKGROUND AND PURPOSE:</h3> Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety efficacy of 2 treatments a randomized trial. <h3>MATERIALS METHODS:</h3> Clipping or were randomly allocated to one more 3- 25-mm aneurysms judged treatable both ways by participating physicians. The study hypothesized that would decrease incidence failure from 13% 4%, composite primary outcome defined as aneurysm...
Importance Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age associated with preexisting burdens changes, visible on neuroimaging but rarely considered in acute decision-making or trials, unknown. Objectives To explore the mediation functional outcome by markers frailty (hereinafter frailty) patients ischemic stroke receiving endovascular thrombectomy (EVT). Design, Setting, and Participants This cohort study was post hoc analysis Safety...
Despite advances in both the surgical and endovascular treatment of intracranial aneurysms, wide-necked basilar tip aneurysms (i.e., which posterior cerebral arteries emanate from base a aneurysm) represent subset that continues to pose technical challenges treatment. We sought demonstrate safety short-term durability novel dual stent-assisted coil embolization technique.Two Neuroform stents (Boston Scientific/Target, Fremont, CA) were deployed artery, one passing through interstices other...
Balloon-mounted coronary stents (BMCS) have been adapted for use in the intracranial circulation treatment of symptomatic atheromatous disease (ICAD). We performed a retrospective analysis our 7-year experience with these devices an attempt to quantify periprocedural risks and long-term outcomes patients ICAD vertebrobasilar (VB) system treated BMCS.A review prospectively maintained database was determine neurological non-neurological BMCS ICAD. Patients were followed serial transcranial...
<h3>SUMMARY:</h3> In this report, we present the fatal spontaneous delayed rupture of a previously unruptured large PICA aneurysm following treatment with PED. Pathology at postmortem examination has supported theory that intra-aneurysmal thrombus may acutely destabilize wall. Aneurysms an anatomic arrangement promote continued flow into neck not be optimal candidates for flow-diversion strategy.
( N Engl J Med . 2024;391:1877–1889. doi:10.1056/NEJMoa2314768) The Australian Reproductive Genetic Carrier Screening Project (Mackenzie’s Mission) aimed to assess the feasibility and outcomes of offering reproductive genetic carrier screening (RGCS) more than 10,000 couples, focusing on identification pathogenic variants in genes associated with severe, childhood-onset conditions. study tested these couples (free charge) for at least 1281 genes, linked about 750 autosomal recessive or...
THIS REVIEW UPDATES: the current status of endothelin receptor antagonists in treatment cerebral vasospasm. Recent preclinical and clinical studies are reviewed, as well trials for other medical indications. Some newer also examined.
<h3>Importance</h3> Some patients have poor outcomes despite small infarcts after endovascular therapy (EVT), while others with large do well. Understanding why these discrepancies occur may help to optimize EVT outcomes. <h3>Objective</h3> To validate exploratory findings from the Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion Emphasis on Minimizing CT Recanalization Times (ESCAPE) trial regarding pretreatment, treatment-related, posttreatment factors...
Ruptured intracranial aneurysms (RIAs) can be managed surgically or endovascularly. In this study, the authors aimed to measure interobserver agreement in selecting best management option for various patients with an RIA.
THIS REVIEW UPDATES the current status of endothelin receptor antagonists in treatment cerebral vasospasm. Recent preclinical and clinical studies are reviewed, as well trials for other medical indications. Some newer also examined.
Glioblastoma (GBM) is an aggressive tumor with a dismal prognosis. Neural stem-like cells contribute to GBM’s poor prognosis by driving drug resistance and maintaining cellular heterogeneity. GBM neural express high levels of brain fatty acid-binding protein (FABP7), which binds polyunsaturated acids (PUFAs) ω-6 arachidonic acid (AA) ω-3 docosahexaenoic (DHA). Similar brain, tissue enriched in AA DHA. However, DHA are considerably lower compared adult brain. Therefore, it possible that...
After aneurysmal SAH, transcranial Doppler is commonly used to monitor cerebral vasospasm. The diagnostic accuracy of flow velocity values in detecting angiographic vasospasm patients requiring urgent endovascular intervention has not been established.We performed a retrospective analysis consecutive series with SAH who underwent (index test) within 24 hours conventional angiography (reference test). judgment 33%, 50%, and 66% degree vessel narrowing on was independently established by...