A5069550484- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Pituitary Gland Disorders and Treatments
- Nerve Injury and Rehabilitation
- Head and Neck Surgical Oncology
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Health, Medicine and Society
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Social Sciences and Governance
- Peripheral Nerve Disorders
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Advanced MRI Techniques and Applications
- Pain Mechanisms and Treatments
- Traumatic Brain Injury Research
University of Liège
2015-2025
Centre Hospitalier Universitaire de Liège
2013-2025
Université de Montpellier
2020-2025
Institut Agro Montpellier
2020-2025
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2020-2025
Institut de Recherche pour le Développement
2012-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
AgroParisTech
2020-2025
Bureau de Recherches Géologiques et Minières
2025
Edinburgh Royal Infirmary
2024
Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) indispensable cofactor oxidative energy metabolism. The less abundant monophosphate (ThMP), triphosphate (ThTP) and adenosine (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers other risk populations. This the first comprehensive...
Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated strong antitumoral potential in preclinical models of malignant gliomas. As it presents an excellent safety profile, we initiated phase 1/2 clinical study this anti-inflammatory drug for the treatment recurrent WHO grade 3 4 astrocytic gliomas adults. 10 patients with advanced anaplastic astrocytoma (n = 2) or glioblastoma 8) aged 32-62 years were recruited prior to planned interim analysis study....
<h3>Background</h3> Unruptured intracranial aneurysms (UIAs) are increasingly diagnosed and commonly treated using endovascular treatment or microsurgical clipping. The safety efficacy of treatments have not been compared in a randomised trial. How to treat patients with UIAs suitable for both options remains unknown. <h3>Methods</h3> We randomly allocated clipping coiling one more 3–25 mm judged treatable ways. primary outcome was failure, defined as: initial failure aneurysm treatment,...
Abstract Background. Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic rates are to be correlated systematic relapses that might arise from remaining stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated GSCs able escape the tumor mass and preferentially colonize adult subventricular zone (SVZ). At a distance initial site, these therefore represent high-quality model clinical...
<h3>BACKGROUND AND PURPOSE:</h3> Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety efficacy of 2 treatments a randomized trial. <h3>MATERIALS METHODS:</h3> Clipping or were randomly allocated to one more 3- 25-mm aneurysms judged treatable both ways by participating physicians. The study hypothesized that would decrease incidence failure from 13% 4%, composite primary outcome defined as aneurysm...
The ability of DRG-derived neurons to survive and attach onto macroporous polylactide (PLA) foams was assessed in vitro. were fabricated using a thermally induced polymer-solvent phase separation. Two types pore structures, namely oriented or interconnected pores, can be produced, depending on the mechanism separation, which turn predicted by thermodynamics pair. Coating porous with polyvinylalcohol (PVA) considerably improved wettability allowed for cell culture. vitro biocompatibility...
The management of cerebrospinal fluid (CSF) fistulae after anterior cranial base fracture remains a surgical challenge. We reviewed our results in the repair CSF complicating multiple fractures via combined intracranial extradural and intradural approach describe treatment algorithm derived from this experience.We retrospectively files 209 patients with an complicated by fistula who were admitted between 1980 2003 to Liège State University Hospital. Among those patients, 109 had persistent...
A major class of axon growth-repulsive molecules associated with CNS scar tissue is the family chondroitin sulphate proteoglycans (CSPGs). Experimental spinal cord injury (SCI) has demonstrated rapid re-expression CSPGs at and around lesion site. The pharmacological digestion in such models results substantially enhanced axonal regeneration a significant functional recovery. potential therapeutic relevance interfering CSPG expression or function following experimental injuries seems clear,...
Spontaneous cellular reorganisation at the lesion site has been investigated following massive spinal cord compression injury in adult rats. By 2 days post operation (p.o.), haemorrhagic necrosis, widespread axonal degeneration, and infiltration by polymorphnuclear granulocytes OX42-positive macrophages were observed site. 7 p.o., low affinity nerve growth factor receptor-positive Schwann cells, from activated roots, identified as they migrated far into lesion. Between 14 overlapping...
Cultured Schwann cells were transplanted at various delays into a spinal cord contusion injury performed low thoracic level in adult female rats. The purified from the dorsal root ganglia of syngeneic animals. transplants well tolerated, and invaded injured cord. As quantified using video image analysis, survival growth poor when grafting procedure was 3–4 days after very good immediately or 10 injury, which cases post-traumatic micro- macrocavitation strongly reduced. In animals grafted but...
Early and robust invasion by macrophages may be one of the reasons why axonal regeneration is more effective in PNS than CNS. Therefore, we have grafted autologous peritoneal labeled with fluorescent latex microspheres into spinal cord compression lesions. At various survival times, studied their effect on expression neuronal (neurofilaments [NF], calcitonin gene-related peptide [CGRP], 5-hydroxytryptamine [5-HT]) nonneuronal markers (myelin-associated glycoprotein [MAG], glial fibrillary...
Abstract In contrast to the central nervous system (CNS), peripheral (PNS) displays an important regenerative ability which is dependent, at least in part, on Schwann cell properties. The mechanisms stimulate cells adapt their behavior after a lesion generate adequate conditions for PNS regeneration remain unknown. this work, we report that adult rat dorsal root ganglion (DRG) neurons are able, performed vivo or when they dissociated and cultured vitro, synthesize transforming growth factor...
Axons undergo Wallerian degeneration (WD) distal to a point of injury. In the lesioned PNS, WD may be followed by successful axonal regeneration and functional recovery. However, in mammalian CNS, there is no significant regeneration. Myelin-associated proteins (MAPs) have been shown play roles preventing CNS. Since relatively little known about such events human CNS pathologies, we performed an immunohistochemical investigation on temporal changes four MAPs during post-mortem spinal cords...
Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases that degrade the matrix and other proteins. Studies in experimental animals demonstrate MMPs play number roles detrimental as well beneficial events after spinal cord injury (SCI). In present correlative investigation, expression pattern several their inhibitors has been investigated human cord. An immunohistochemical investigation post mortem samples control lesioned cords was performed. All patients with...
Synaptic vesicle proteins 2 (SV2) are neuronal vesicles membrane glycoproteins that appear as important targets in the treatment of partial and generalized epilepsies. Therefore, we analysed expression SV2 isoforms hippocampus patients with temporal lobe epilepsy (TLE).SV2A, SV2B SV2C immunostaining QuantiGene branched DNA assay were performed on biopsies from 31 consecutive TLE mesial sclerosis (MTS) compared 10 autopsy controls. was further Timm's staining, synaptophysin, Zinc transporter...
Introduction Obsessive-compulsive disorder (OCD) is a challenging neuropsychiatric condition with subset of patients remaining refractory to conventional treatments. Deep brain stimulation (DBS) the bed nucleus stria terminalis (BNST) has shown promise for severe, treatment-resistant OCD. This case report examines relationship between plasma oxytocin levels and OCD symptom severity following BNST-DBS. Methods A 36-year-old patient long-standing, underwent stereotactic implantation DBS...
In the alluvial plains of large rivers, study flood dynamics is essential to appreciate water resource variations and preserve associated ecosystem services, in particular biodiversity, groundwater recharge flood-recession agriculture. Hydraulic modelling provides valuable opportunities simulate surface flows but are challenged by very flat topography sparse field observations, especially Africa. By combining advances earth observations (Digital Elevation Models Sentinel-2 areas), (stage,...
Abstract We describe an experimental model to produce closed traumatic injuries the spinal cord of adult rats. This uses inflatable balloon that is introduced in dorsal subdural space and moved a location rostral laminectomy site. The trauma can be graded by varying either duration compression or volume saline used inflate balloon. locomotor deficit animals with various degrees injury has been assessed at increasing delays after trauma. parameters generating transient definitive deficits...
Abstract This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an original method consisting aggregation calibrated poly‐D,L‐lactide microparticles. The size interstices between aggregated microspheres in direct relationship to microsphere diameter. A first approach based on coating with poly(vinyl alcohol) followed chemically crosslinking layers...