A5074794983- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- interferon and immune responses
- Peripheral Neuropathies and Disorders
- Viral Infections and Outbreaks Research
- Immune cells in cancer
- Virus-based gene therapy research
- Nerve injury and regeneration
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Systemic Lupus Erythematosus Research
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Single-cell and spatial transcriptomics
- RNA regulation and disease
- AI in cancer detection
University of Geneva
2015-2024
University Hospital of Geneva
2015-2024
University of Lausanne
2023
University Hospital of Lausanne
2023
Hôpital Beau-Séjour
2022
Geneva College
2013-2021
University of Basel
2019
University of Göttingen
2007-2016
Universitätsmedizin Göttingen
2004-2016
World Health Organization
2013
Sound the Alarm When small protein fragments or nucleic acids derived from an invading pathogen are detected by pattern recognition receptors on immune cells, innate response is triggered. This event activates cells of adaptive system, and together, both responses clear infection. Infections also induce release “danger-associated molecular patterns,” alarmins, host as a result tissue damage. Whether these important for ensuing less clear. Bonilla et al. (p. 984 , published online 2 February)...
Caloric restriction (CR) stimulates development of functional beige fat and extends healthy lifespan. Here we show that compositional changes in the gut microbiota contribute to a number CR-induced metabolic improvements promote browning. Mechanistically, these effects are linked lower expression key bacterial enzymes necessary for lipid A biosynthesis, critical lipopolysaccharide (LPS) building component. The decreased LPS dictates tone innate immune response during CR, leading increased...
Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune providing bystander activation. Here, we characterize the functioning brain-resident (bTRM) in an animal model viral infection. bTRM were subject spontaneous homeostatic proliferation largely refractory systemic cell depletion. After reinfection mice, rapidly acquired cytotoxic effector function prevented fatal brain infection, even...
Inflammation-induced neurodegeneration is a defining feature of multiple sclerosis (MS), yet the underlying mechanisms remain unclear. By dissecting neuronal inflammatory stress response, we discovered that neurons in MS and its mouse model induce stimulator interferon genes (STING). However, activation STING requires detachment from stromal interaction molecule 1 (STIM1), process triggered by glutamate excitotoxicity. This initiates non-canonical signaling, which leads to autophagic...
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which water-channel protein AQP4 target antigen
The limited plastic and regenerative capabilities of axons in the adult mammalian CNS can be enhanced by application a monoclonal antibody (mAb), IN-1, raised against myelin-associated neurite growth inhibitor Nogo-A. aim present study was to investigate effects this treatment on functional recovery rats with dorsal over-hemisection spinal cord. Directly after injury, half animals were implanted mAb IN-1-secreting hybridoma cells, whereas others received cells secreting control (anti-HRP). A...
Recent studies have revealed widespread demyelination in the cortex of patients with chronic multiple sclerosis. In contrast to white matter lesions, cortical sclerosis lesions are accompanied by only minor inflammation. Research into pathogenesis lesion formation has been hampered fact that conventional rodent model sclerosis, experimental autoimmune encephalomyelitis (EAE), does not regularly affect cortex. To overcome this limitation we developed a new rat Lesions were stereotactically...