A5003828374- Immunotherapy and Immune Responses
- Multiple Sclerosis Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Adenosine and Purinergic Signaling
- Long-Term Effects of COVID-19
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
- Ion Channels and Receptors
- Polyomavirus and related diseases
- Immune Response and Inflammation
- COVID-19 and Mental Health
- Electrolyte and hormonal disorders
- Peripheral Neuropathies and Disorders
- Neuroendocrine regulation and behavior
- Systemic Sclerosis and Related Diseases
- Autoimmune Neurological Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Melanoma and MAPK Pathways
- Connexins and lens biology
- Psoriasis: Treatment and Pathogenesis
- Barrier Structure and Function Studies
Charité - Universitätsmedizin Berlin
2012-2025
Freie Universität Berlin
2023-2024
German Center for Neurodegenerative Diseases
2024
Humboldt-Universität zu Berlin
2023-2024
Universität Hamburg
2012-2023
University Medical Center Hamburg-Eppendorf
2012-2023
Klinik und Poliklinik für Neurologie
2014-2021
Institute of Neuroimmunology of the Slovak Academy of Sciences
2016
Social Neuroscience Lab
2014
University of Münster
2014
Abstract Neuropsychiatric complications associated with coronavirus disease 2019 caused by the Coronavirus SARS-CoV-2 (COVID-19) are increasingly appreciated. While most studies have focussed on severely affected individuals during acute infection, it remains unclear whether mild COVID-19 results in neurocognitive deficits young patients. Here, we established a screening approach to detect cognitive deficiencies post-COVID-19 In this cross-sectional study, recruited 18 mostly patients 20–105...
Recent findings indicate a pathogenic involvement of IL‐17‐producing CD8 + T cells in multiple sclerosis (MS). IL‐17 production has been attributed to subset that belong the mucosal‐associated invariant (MAIT) cell population. Here, we report reduction MAIT blood MS patients compared with healthy individuals, which significantly correlated IL‐18 serum levels patients. In vitro stimulation peripheral mononuclear from individuals and specifically activated cells. Moreover, together T‐cell...
Brain injury during stroke results in oxidative stress and the release of factors that include extracellular Ca(2+), hydrogen peroxide, adenosine diphosphate ribose, nicotinic acid adenine dinucleotide phosphate. These alterations milieu change activity transient receptor potential melastatin subfamily member 2 (TRPM2), a nonselective cation channel expressed central nervous system immune system. Our goal was to evaluate contribution TRPM2 tissue damage after stroke.In accordance with...
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severely debilitating condition which markedly restricts activity and function of affected people. Since the beginning COVID-19 pandemic ME/CFS related to post-acute (PACS) can be diagnosed in subset patients presenting with persistent 6 months after mostly mild SARS-CoV-2 infection by fulfillment Canadian Consensus Criteria (CCC 2003). Induction autoimmunity viral mechanism under intensive investigation. In...
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with continuous neuronal loss. Treatment clinical progression remains challenging due to lack insights into inflammation-induced neurodegenerative pathways. Here, we show that an imbalance in receptor interactome driving glutamate excitotoxicity neurons MS patients and identify risk–associated metabotropic 8 (GRM8) as decisive modulator. Mechanistically, GRM8 activation counteracted cAMP accumulation,...
Skin-migratory dendritic cells (migDCs) are pivotal antigen-presenting that continuously transport antigens to draining lymph nodes and regulate immune responses. However, identification of migDCs is complicated by the lack distinguishing markers, it remains unclear which molecules determine their migratory capacity during inflammation. We show that, in skin, neuronal plasticity molecule activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) was strictly...
Abstract The ability of CD4+ T cells to differentiate into pathogenic Th1 and Th17 or protective regulatory plays a pivotal role in the pathogenesis autoimmune diseases. Recent data suggest that cell subsets display considerable plasticity. This plasticity seems be critical factor for their pathogenicity, but also potential transition effector toward more tolerogenic phenotype. aim current study was analyze mouse model acute crescentic glomerulonephritis chronic lupus nephritis. By...
Abstract Objective Autologous hematopoietic stem cell transplantation (aHSCT) is increasingly recognized as a potential therapy for patients with highly active multiple sclerosis (MS). This study aims to assess outcome differences in disease activity MS treated either aHSCT or alemtuzumab. Methods We conducted monocentric registry‐based cohort by recording the clinical course (EDSS and relapses), MRI parameters (new T2 lesions), neuropsychological assessment all 19 receiving aHSCT, 21...
Migratory dendritic cells (migDCs) continuously patrol tissues and are activated by injury inflammation. Extracellular adenosine triphosphate (ATP) is released damaged or actively secreted during inflammation increases migDC motility. However, the underlying molecular mechanisms which ATP accelerates migration not understood. Here, we show that migDCs can be distinguished from other DC subsets immune their expression of voltage-gated calcium channel subunit β3 (Cavβ3; CACNB3), exclusively...
Recent association studies have linked numerous genetic variants with an increased risk for multiple sclerosis, although their functional relevance remains largely unknown. Here we investigated phenotypical and consequences of a variant in the CD226 gene that, among other autoimmune diseases, predisposes to sclerosis. Phenotypically, effector regulatory CD4(+) memory T cells healthy individuals carrying predisposing showed, comparison carriers protective variant, reduced surface expression...
Among laboratory mouse strains many genes are differentially expressed in the same cell population. As consequence, gene targeting 129-derived embryonic stem cells (ESCs) and backcrossing modified mice onto C57BL/6 background can introduce passenger mutations close proximity of targeted gene. Here, we demonstrate that several transgenic carry a P2rx7 mutation affects function T cells. By example P2rx4tm1Rass P2X4ko express higher levels P2X7 more sensitive toward activators ATP NAD+,...
Background: Balancing treatment benefits and risks is part of a shared decision-making process before initiating any in multiple sclerosis (MS). Patients understand, appreciate profit from evidence-based patient information (EBPI). While these processes are well known, long-term risk awareness processing patients has not been studied. Mitoxantrone MS associated with major potential harms – leukaemia (LK) cardiotoxicity (CT). The knowledge perception among currently or previously treated...
Abstract The voltage-gated proton channel Hv1 regulates fluxes across membranes, thereby influencing pH-dependent processes. Plasmacytoid dendritic cells (pDCs) require a particularly tight regulation of endosomal pH to ensure strong type I IFN secretion exclusively during infection, avoiding autoimmunity. However, whether is important for control in pDCs presently unknown. In this study, we show that mouse achieve potent responses after the recognition foreign DNA by TLR9. Genetic...
<b>Anamnese und klinischer Befund |</b> Ein Patient mit stärksten Schulterschmerzen beidseits präsentierte sich in der Notaufnahme. <b>Untersuchungen Im initialen Labor zeigten deutlich erhöhte Transaminasen. <b>Diagnose Serologisch mittels PCR konnte eine Hepatitis festgestellt werden. Die Neurologische Abklärung erbrachte Neuralgische Amyotrophie. <b>Therapie Verlauf sistierten spontan nach verschwinden HEV-Virämie. <b>Folgerung Patienten unklarer Genese erhöhten Transaminasen sollten auf...
The key function of migratory dendritic cells (migDCs) is to take up antigens in peripheral tissues and migrate draining lymph nodes (dLN) initiate immune responses. Recently, we discovered that the mouse system activity-regulated cytoskeleton associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) exclusively expressed by migDCs a central driver fast inflammatory migration. However, frequency Arc/Arg3.1-expressing different migDC subsets Langerhans (LCs), their phylogenetic origin,...
Glucocorticoids seem to modify the release and effects of plasma arginine vasopressin (pAVP). However, underlying processes are not well understood. This study aimed evaluate mechanism modulating glucocorticoids on pAVP renal water reabsorption.Fluid deprivation tests were performed without (d0) after one (d1) five days (d5) oral prednisolone (Pred) pretreatment in a dosage relevant drug therapy (30 mg/day).Twelve healthy male volunteers participated this trial.Plasma urinary osmolality,...
Dendritic cell (DC) vaccination has proven to be an effective and safe adjuvant for cancer immunotherapies. As the presence of DCs within tumor microenvironment promotes adaptive antitumor immunity, enhancement DC migration toward following might represent one possible approach increase its therapeutic efficacy. While recent findings suggest activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) as critical regulator in context autoimmune diseases, we...