A5100711485- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Marine animal studies overview
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Cloud Data Security Solutions
- Genetic Mapping and Diversity in Plants and Animals
- Celiac Disease Research and Management
- Melanoma and MAPK Pathways
- Genetic Neurodegenerative Diseases
- Gene expression and cancer classification
- Cryptography and Data Security
- RNA modifications and cancer
- Security and Verification in Computing
- Genomics and Phylogenetic Studies
- Avian ecology and behavior
- Genetics, Aging, and Longevity in Model Organisms
- T-cell and B-cell Immunology
- Mitochondrial Function and Pathology
- Genetic diversity and population structure
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
BeiGene (China)
2020-2025
Guilin Medical University
2024-2025
Nanjing University
2022-2025
Xi’an Children’s Hospital
2024
Hainan Normal University
2000-2023
China Medical University
2019-2022
University of California, Irvine
2017-2021
Heidelberg University
2021
German Cancer Research Center
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2021
Abstract Mutations that add, subtract, rearrange, or otherwise refashion genome structure often affect phenotypes, although the fragmented nature of most contemporary assemblies obscures them. To discover such mutations, we assembled first new reference-quality Drosophila melanogaster since its initial sequencing. By comparing this to existing D. assembly, created a structural variant map unprecedented resolution and identified extensive genetic variation has remained hidden until now. Many...
Topologically associating domains (TADs) were recently identified as fundamental units of three-dimensional eukaryotic genomic organization, although our knowledge the influence TADs on genome evolution remains preliminary. To study molecular in Drosophila species, we constructed a new reference-grade assembly and accompanying high-resolution TAD map for D. pseudoobscura . Comparison melanogaster , which are separated by ∼49 million years divergence, showed that ∼30%–40% their genomes retain...
PLIN2 (adipose differentiation-related protein) belongs to the perilipin family and is a marker of lipid droplets (LDs). Numerous types tumor exhibit high level, but its tumorigenic or tumor-suppressive role has been in debate. Recently, LDs serve as innate immune hubs show antimicrobial capacity. We here aimed investigate heterogeneous functions microenvironment regulation.This retrospective study included 96 oral squamous cell carcinoma (OSCC) samples analyzed spatial distribution by...
Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein (MAP4K) family. It has been reported that HPK1 negatively regulates activation T cells. Several compounds have developed and tested in clinical trials to target for cancer immunotherapy. However, whether inhibition sufficient eliminate immunosuppressive function HPK1, particularly cells, remains elusive. In this study, genetic tools were used edit human lymphocyte cell line Jurkat. The HPK1-null...
Objective To detect the expression of CEA-related cell adhesion molecule 5 (CEACAM5) in non-small-cell lung cancer (NSCLC) and explore its function progression development NSCLC. Methods qRT-PCR immunohistochemistry were performed to CEACAM5 human NSCLC tissues lines. The correlation between clinicopathological features patients with was also investigated. MTT, colony formation, wound healing, immunoblot assays functions cells vitro, immunoblotting used effects on p38–Smad2/3 signaling....
The mutation of K-RAS represents one the most frequent genetic alterations in cancer. Targeting downstream effectors RAS, including MEK and ERK, has limited clinical success cancer patients with mutations. reduced sensitivity K-RAS-mutated cells to certain inhibitors (MEKi) is associated feedback phosphorylation by C-RAF reactivation mitogen-activated protein kinase (MAPK) signaling. Here, we report that RAF dimer lifirafenib (BGB-283) compound C show a strong synergistic effect MEKi,...
An increasing understanding of the genes and molecular pathways glioblastoma multiforme (GBM) can provide us a useful insight for development more effective targeted therapeutic.To investigate expression clinical significance miR-299 its target in GBM, levels gene human normal brain tissues GBM were analyzed silico using microarray hierarchical clustering analysis followed by validation with quantitative RT-PCR.Our results show that is up-regulated patients. Moreover, patients low had longer...
Abstract Background Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins are associated with risk diseases. In current study, we evaluated gene ( ERAP1 ERAP2 ) on susceptibility to cervical intraepithelial neoplasia (CIN) cancer. Methods Six single nucleotide (SNPs) 5 SNPs were selected genotyped 556 CIN...
Most studies on the relationship between measures of song behavior and sizes control nuclei have focused one or two oscine species, often show inconsistent results. To address this issue, we first measured four variables for complexity, i.e., repertoire size, syllable mean number syllables per phrase (MNS) in longest (NSLP), three nuclei, HVC, RA (the robust nucleus arcopallium), Area × 14 species from eight families. tackle problem statistical non-independence that probably existed among...
We show that the learned vocalizations of male and female large-billed crows (Corvus macrorhynchos) are similar their functions physical features significant differences from those other oscine species. investigate whether song control nuclei any sexual in size, reflecting singing behavior, these different songbirds terms neural connectivity size relative to forebrain. Our Nissl staining results reveal 1) four examined (HVC; robust nucleus arcopallium [RA]; Area X; dorsolateral medial...
Abstract Topologically associating domains (TADs) were recently identified as fundamental units of three-dimensional eukaryotic genomic organization, though our knowledge the influence TADs on genome evolution remains preliminary. To study molecular in Drosophila species, we constructed a new reference-grade assembly and accompanying high-resolution TAD map for D. pseudoobscura . Comparison melanogaster , which are separated by ∼49 million years divergence, showed that ∼30-40% their genomes...
The analysis of polymorphic variations in the human major histocompatibility complex (MHC) class II genomic region on short-arm chromosome 6 is a scientific enquiry to better understand diversity population structure and effects evolutionary processes such as recombination, mutation, genetic drift, demographic history, natural selection. In order investigate associations between polymorphisms HLA-DRB1 gene recent Alu insertions (POALINs) HLA region, we genotyped five loci (AluDPB2, AluDQA2,...
Songbirds have the rare ability of auditory-vocal learning and maintenance. Up to now, organization function nucleus magnocellularis (NM), first relay avian ascending auditory pathway is largely based on studies in non-vocal species, such as chickens owls. To investigate whether NM exhibits different histochemical properties associated with processing songbirds, we examined expression patterns three calcium-binding proteins (CaBPs), including calretinin (CR), parvalbumin (PV) calbindin-D28k...