A5080114510- Botany and Plant Ecology Studies
- Climate change and permafrost
- Species Distribution and Climate Change
- Peatlands and Wetlands Ecology
- Multiple Sclerosis Research Studies
- Tree-ring climate responses
- Cryospheric studies and observations
- Amphibian and Reptile Biology
- Turtle Biology and Conservation
- Geology and Paleoclimatology Research
- Electrospun Nanofibers in Biomedical Applications
- Ecology and biodiversity studies
- Tissue Engineering and Regenerative Medicine
- Plant and animal studies
- Ecology and Vegetation Dynamics Studies
- Insect and Arachnid Ecology and Behavior
- Bryophyte Studies and Records
- Helminth infection and control
- Avian ecology and behavior
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Lichen and fungal ecology
- Wildlife Ecology and Conservation
University of South-Eastern Norway
2020-2025
Universität Hamburg
2011-2024
University Medical Center Hamburg-Eppendorf
2011-2024
University of Calcutta
2023
University School of Nashville
2022
Centrum für Integrierte Onkologie
2019
University Hospital Cologne
2016-2019
Institute of Neuroimmunology of the Slovak Academy of Sciences
2018
Klinik und Poliklinik für Neurologie
2015-2018
University of Cologne
2017
Antigen-coupled cells result in antigen-specific tolerization for treatment of multiple sclerosis.
Abstract Recent studies from mountainous areas of small spatial extent (<2500 km 2 ) suggest that fine‐grained thermal variability over tens or hundreds metres exceeds much the climate warming expected for coming decades. Such in temperature provides buffering to mitigate climate‐change impacts. Is this local restricted topographically complex terrains? To answer this, we here study across a 2500‐km wide latitudinal gradient N orthern E urope encompassing large array topographic...
BackgroundProgressive multiple sclerosis (MS) is characterized by compartmentalized smoldering neuroinflammation caused the proliferation of immune cells residing in central nervous system (CNS), including B cells. Although inflammatory activity can be prevented immunomodulatory therapies during early disease, such typically fail to halt disease progression. CD19 chimeric antigen receptor (CAR)-T cell have revolutionized field hematologic malignancies. generally considered efficacious,...
Abstract Multiple sclerosis (MS) is a T cell–driven inflammatory disease of the CNS. Research on cell subsets involved in MS pathogenesis has mainly focused classical CD4+ cells, especially Th17 as they produce proinflammatory, MS-associated cytokine IL-17. However, abundant unconventional mucosal-associated invariant (MAIT) cells are also able to MAIT characterized by high CD161 expression and semi-invariant Vα7.2 TCR, with which recognize bacterial yeast Ags derived from riboflavin...
Primary progressive multiple sclerosis (PPMS) shows highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks PPMS make it difficult to diagnose currently impossible efficiently treat. This study aimed identify plasma metabolite profiles that allow diagnosis its differentiation from the relapsing-remitting subtype (RRMS), primary neurodegenerative (Parkinson´s (PD)) healthy controls (HC) significantly change during...
Abstract Aim Previous research on how climatic niches vary across species ranges has focused a limited number of species, mostly invasive, and not, to date, been very conclusive. Here we assess the degree niche conservatism between distant populations native alpine plant that have separated for thousands years. Location European A lps F ennoscandia. Methods Of studied pool 888 terrestrial vascular occurring in both ennoscandia, used two complementary approaches test quantify climatic‐niche...
Lichen heaths are declining in abundance while shrubs increasing their range alpine and arctic areas due to climate change. This can have a large impact on the surface albedo of these areas. The aim this article is quantify difference between lichen shrub-dominated vegetation variability within heaths. Several environmental conditions that influence measurements considered. We measured twenty lichen- plots an mountain area southern Norway summer 2018 with two radiometers using paired plot...
Abstract. Lichen heaths are declining in abundance alpine and Arctic areas partly due to an increasing competition with shrubs. This shift vegetation types might have important consequences for the microclimate climate on a larger scale. The aim of our study is measure difference microclimatic conditions between lichen shrub during growing season. With paired plot design, we measured net radiation, soil heat flux, temperature moisture mountain area southern Norway summer 2018 2019. We...
Recent association studies have linked numerous genetic variants with an increased risk for multiple sclerosis, although their functional relevance remains largely unknown. Here we investigated phenotypical and consequences of a variant in the CD226 gene that, among other autoimmune diseases, predisposes to sclerosis. Phenotypically, effector regulatory CD4(+) memory T cells healthy individuals carrying predisposing showed, comparison carriers protective variant, reduced surface expression...
Objective To investigate whether oral administration of a standardised frankincense extract (SFE) is safe and reduces disease activity in patients with relapsing-remitting multiple sclerosis (RRMS). Methods We performed an investigator-initiated, bicentric phase IIa, open-label, baseline-to-treatment pilot study SFE RRMS ( NCT01450124 ). After 4-month baseline observation phase, were treated for 8 months option to extend treatment up 36 months. The primary outcome measures the number volume...
Background Neurodegeneration in multiple sclerosis (MS) affects the visual system but dynamics and pathomechanisms over several years especially primary progressive MS (PPMS) are not fully understood. Methods We assessed longitudinal changes function, retinal neurodegeneration using optical coherence tomography, MRI serum NfL (sNfL) levels a prospective PPMS cohort matched healthy controls. investigated time, correlations between outcomes with loss of function. Results followed 81 patients...
The relative contribution of extrinsic and intrinsic factors affecting lizard movement patterns have rarely been examined. We were interested in understanding the effects such as seasonality forest cover, along with factor body length on home range size, coarse-scale habitat selection endangered Guatemalan Beaded Lizard (Heloderma charlesbogerti). predict that ranges, core areas will be reduced dry season compared to those wet season. Twelve individuals (five males seven females) radio...
Abstract Global warming is expected to affect movement‐related thermoregulation in ectotherms, but the likely effects on thermoconforming lizards, which spend little energy behavior, are unclear. We used Guatemalan beaded lizard ( Heloderma charlesbogerti ) as a model species investigate of ambient temperature and barometric pressure (a cue for rain study area) activity intensity structure movement paths. tracked 12 individuals over total 148 animal days during wet season 2019 using...
Autologous hematopoietic stem cell transplantation (aHSCT) has been used as a therapeutic approach in multiple sclerosis (MS). However, it is still unclear if the immune system that emerges from autologous CD34+ progenitor cells (HPC) of MS patients pre-conditioned to re-develop proinflammatory phenotype. The objective this article compare whole genome gene and microRNA expression signature HPC healthy donors (HD). were isolated peripheral blood eight five HD analyzed by microarray. Among...
Abstract Background Semi-aquatic mammals exploit resources both on land and in water may require to meet their habitat requirements including food- building resources, refuges, for social interactions with conspecifics. Within this, the specific availability of terrestrial aquatic is expected impact individual fitness. Beavers are highly dependent movement protection from predators. They central place foragers mostly forage woody vegetation near although also be an important food resource....
Background: Theories regarding patterns of species richness often focus on single factors such as stress, productivity and disturbance, but these have recently been challenged. Vascular plant is also frequently used a surrogate for in other groups, relationships rarely studied alpine areas.Aims: To establish the relationship between environmental variables vascular plants, mosses liverworts, to identify common across different groups.Methods: A stratified random sampling procedure was...
Long-term monitoring is essential for the identification of population trends, and to understand how these trends are affected by climate variability. The El Niño Southern Oscillation (ENSO) strongest global interannual pattern variability, resulting in disruption annual phenological cycles sea turtles. Among turtles, Olive Ridley (Lepidochelys olivacea) most abundant, on many beaches their nests relocated hatcheries as part conservation management, especially northern Central America....
Abstract Animals balance foraging with other activities, and activity patterns may differ between sexes due to differing physical requirements reproductive investments. Sex-specific behavioural differences are common in sexually dimorphic mammals, but have received limited research attention monomorphic mammals where the similar body size. Eurasian beavers ( Castor fiber ) obligate monogamous a good model species study sex-specific differences. As females increase energy expenditure during...
Climate change research on sea turtles has focused the impact of rising temperatures sex ratios, while thermal ecology natural nesting grounds received less attention. Many beaches are highly affected by vegetation loss and urbanization which in turn may affect their profile, particularly at with dark volcanic sand. We studied sand two urban-developed turtle Guatemala for years, potential effect nests using olive ridley as model species. hypothesized that local weather, type cover surface,...
Vegetation types confi ned to calcareous bedrocks are often characterized by high species richness, and rare red- listed plants occur frequently. Snow depth duration of particular importance for the fl oristic composition mountain vegetation we therefore wanted quantify date snowmelt thereby discuss possible effects future climate change. In two areas with calcium-rich bedrocks, 106 sample plots (2 x 2 m) were selected a stratifi ed random sampling, cover broad range snow cover, topography...