A5081443324- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Aortic aneurysm repair treatments
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Lung Cancer Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
University of Cologne
2016-2025
University Hospital Cologne
2016-2025
Centrum für Integrierte Onkologie
2011-2025
Friedrich Schiller University Jena
2001-2024
Lungenklinik Köln-Merheim
2011-2024
Jena University Hospital
2001-2024
University Hospital Bonn
2024
Deutsches Herzzentrum der Charité
2008-2023
Toronto Public Health
2023
University of Technology Sydney
2021
The number of alveoli is a key structural determinant lung architecture. A design-based stereologic approach was used for the direct and unbiased estimation alveolar in human lung. principle based on two-dimensional topology three-dimensional space free assumptions shape, size, or spatial orientation alveoli. Alveolar estimated by counting their openings at level septal edges, where they form network. Mathematically, Euler this network using physical disectors light microscopic level. In six...
Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has implicated mediate this oxidation. In addition, the 5-lipoxygenase cascade leads formation leukotrienes, which exhibit strong proinflammatory activities in cardiovascular tissues. Here, we studied both lipoxygenase pathways human atherosclerosis. The pathway was abundantly expressed arterial walls patients afflicted with various lesion...
During the last decade, mesenchymal stem cells (MSCs) have gained much attention in field of regenerative medicine due to their capacity differentiate into different cell types and promote immunosuppressive effects. However, underlying mechanism MSC-mediated immunoregulation is not fully understood so far. Macrophages are distinguished classical activated, pro-inflammatory M1 alternatively activated M2 cells, which possess functions transcriptional profiles with respect inflammatory...
Background: Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE may lead to a sudden release of inflammatory mediators, which is associated postoperative organ dysfunction. We investigated effect hemoadsorption during on Methods: This multicenter, randomized, nonblinded, controlled trial assigned undergoing cardiac for (integration CytoSorb cardiopulmonary bypass) or control. The primary outcome (change sequential failure...
BackgroundCurrent treatment recommendations for patients with heart failure and secondary mitral regurgitation include transcatheter edge-to-edge repair mitral-valve surgery. Data from randomized trials comparing these therapies are lacking in this patient population.MethodsIn noninferiority trial conducted Germany, who continued to have symptoms despite guideline-directed medical therapy were randomly assigned, a 1:1 ratio, undergo either (intervention group) or surgical replacement...
Background— Impairment of intracellular Ca 2+ homeostasis and mitochondrial function has been implicated in the development cardiomyopathy. Mitochondrial uptake is thought to be mediated by uniporter (MCU) a thus far speculative non-MCU pathway. However, identity properties these pathways are matter intense debate, possible functional alterations diseased states have remained elusive. Methods Results— By patch clamping inner membrane mitochondria from nonfailing failing human hearts, we...
Background— Surgical aortic valve replacement in patients with small annular dimensions is challenging because they are at increased risk for prosthesis–patient mismatch and impaired outcomes. Transcatheter might be a good alternative; however, comparative data on different transcatheter heart valves missing. Methods Results— This multicenter, propensity score–matched study compared hemodynamics early clinical outcomes 246 an annulus area <400 mm 2 undergoing either self-expanding...
Innate immune responses and rapid recruitment of leukocytes, which regulate inflammation subsequent healing, play a key role in acute myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is critically involved chromatin decondensation during the release Neutrophil Extracellular Traps (NETs) by activated neutrophils. Alternatively macrophages (M2) accurate collagen deposition determine repair infarcted heart. In this study, we investigated impact NETs on macrophage polarization...
In the third report of European Registry for Patients with Mechanical Circulatory Support Association Cardio-Thoracic Surgery, outcomes patients receiving mechanical circulatory support are reviewed in relation to implant era.Procedures adult (January 2011-June 2020) were included. from centres <60% follow-ups completed excluded. Outcomes stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) calculated early phase (<3 months) late (>3 months). Risk factors...
Abstract OBJECTIVES This fourth report aimed to provide insights into patient characteristics, outcomes, and standardized outcome ratios of patients implanted with durable Mechanical Circulatory Support across participating centers in the European Registry for Patients (EUROMACS) registry. METHODS All registered receiving mechanical circulatory support up August 2024 were included. Expected number events predicted using penalized logistic regression. Standardized (Observed/Expected events)...
Background. There are no data on the effects of mycophenolate mofetil (MMF) incidence bronchiolitis obliterans syndrome (BOS) in lung-transplant patients. This study attempted to determine whether MMF reduces BOS de novo lung transplant recipients compared with azathioprine (AZA). Methods. prospective, randomized, open-label, multicenter AZA combination induction therapy, cyclosporine (Neoral) and corticosteroids patients receiving their first transplant. Primary endpoint was at 3 years....