A5052832997- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Cardiac and Coronary Surgery Techniques
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrhythmias and Treatments
- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- Surgical site infection prevention
University Hospital of Basel
2020-2025
Medical University of Vienna
2010-2025
University of Basel
2022-2025
Hospital Base
2023
Ludwig Boltzmann Cluster for Cardiovascular Research
2010-2020
Klinik Hietzing
2014-2019
University of Vienna
2014
Vienna General Hospital
2010
To analyse the clinical outcomes of surgical repair DeBakey type I and III aortic dissection (AD) by using frozen elephant trunk (FET) technique, to evaluate postoperative behaviour residual aorta. In total, 27 consecutive patients underwent treatment thoracic aorta for AD with FET technique in a tertiary-care hospital Vienna/Austria between 2005 2012, were enrolled this case series study. All operations performed under circulatory arrest bilateral antegrade cerebral perfusion. During...
Background/Objectives: The present study introduces our targeted approach for concomitant surgical ablation (CSA) using non-invasive phase mapping (NIPM) and describes its effectiveness regarding freedom from atrial fibrillation (AF). Methods: This retrospective included cardiac patients undergoing preoperative NIPM CSA guidance. primary outcome was AF six months after surgery. Key secondary outcomes were at hospital discharge three months, frequency of biatrial ablation, feasibility safety,...
Abstract OBJECTIVES This fourth report aimed to provide insights into patient characteristics, outcomes, and standardized outcome ratios of patients implanted with durable Mechanical Circulatory Support across participating centers in the European Registry for Patients (EUROMACS) registry. METHODS All registered receiving mechanical circulatory support up August 2024 were included. Expected number events predicted using penalized logistic regression. Standardized (Observed/Expected events)...
Introduction: Postoperative atrial fibrillation (POAF) after cardiac surgery is associated with higher morbidity and mortality. This paper presents several studies that conclude the presence of an aberrant p-terminal force vector in lead V1 (PTFV1) has been identified as a significant predictor non-surgical population. It uncertain whether or not there association PTFV1 new-onset POAF patients surgery. Methods: In this secondary analysis, adult undergoing on-pump for aortocoronary bypasses,...
Aim of this study was to investigate how different indices express aortic stiffness can be understood and what the impact loading conditions is. Thoracic aortas from swine (n = 6) sheep were tested in a pulsatile mock circulation loop. Aortas loaded at constant heart rate stroke volume increasing diastolic pressure with pulse 40 mmHg 60/20 180/140 20 steps. Data analyzed using commonly used formulas calculate absolute strain, dynamic circumferential compliance, distensibility, wave velocity,...
Summary Reparixin, a CXCR 1/2 antagonist, has been shown to mitigate ischaemia–reperfusion injury (IRI) in various organ systems animals, but data humans are scarce. The aim of this double-blinded, placebo-controlled pilot study was evaluate the safety and efficacy reparixin suppress IRI inflammation patients undergoing on-pump coronary artery bypass grafting (CABG). Patients received either or placebo (n = 16 each group) after induction anaesthesia until 8 h cardiopulmonary (CPB). We...
Left ventricular (LV) hypertrophy is characterized by cardiomyocyte and interstitial fibrosis ultimately leading to increased myocardial stiffness reduced contractility. There substantial evidence that the altered expression of matrix metalloproteinases (MMP) Tenascin-C (TN-C) are associated with progression adverse LV remodeling. However, role TN-C in development because chronic pressure overload as well regulatory on MMPs remains unknown.In a knockout mouse model TN-C, we investigated...
Pulmonary arterial hypertension is a severe and progressive disease characterized by pulmonary vascular remodeling process with expansion of collateral endothelial cells total vessel occlusion. Endothelial are believed to be at the forefront process. Vascular growth factor (VEGF) its tyrosine kinase receptor, VEGF receptor-2 (VEGFR-2), play central role in angiogenesis, cell protection, but also destabilization barrier function. Therefore, we investigated consequences altered signaling an...
Background: Aim of this study was to evaluate the outcomes endocarditis patients undergoing valve surgery with Cytosorb® hemoadsorption (HA) device during cardiopulmonary bypass. Methods: From 2009 until 2019, 241 had undergone due at Department Cardiac Surgery, University Hospital Basel. We compared who received HA (n = 41) versus without 200), after applying inverse probability treatment weighting. Results: In-hospital mortality, major adverse cardiac and cerebrovascular events...
Abstract Aims Tenascin‐C (TN‐C) is suggested to be detrimental in cardiac remodelling after myocardial infarction (MI). The aim of this study reveal the effects TN‐C on extracellular matrix organization and its haemodynamic influence an experimental mouse model MI cell culture during hypoxic conditions. Methods results Myocardial was induced knockout (TN‐C KO) wild‐type mice. Six weeks later, function studied by magnetic resonance imaging under isolated working heart mRNA levels...
Abstract Background To evaluate the midterm follow-up and 5-year survival outcome of minimally invasive direct coronary artery bypass (MIDCAB) procedure compared with general Swiss population. Methods Retrospective study on preoperative data, intraoperative postoperative patients who underwent MIDCAB surgery between June 2010 February 2019. assess validity this surgical therapy, outcomes were data a gender- age-matched cohort population taken from database Federal Statistical Office. Results...
AimsThe region-specific mechanical function of left ventricular (LV) murine cardiomyocytes and the role phosphorylation oxidative modifications myofilament proteins were investigated in process post-myocardial infarction (MI) remodelling 10 weeks after ligation anterior descending (LAD) coronary artery.
Identification of microRNAs (miRNA) associated with cardiopulmonary bypass, cardiac arrest and subsequent myocardial ischemia/reperfusion may unravel novel therapeutic targets biomarkers. The primary aim the present study was to investigate effects bypass temperature cardioplegic on miRNA profile in pigs' left ventricular tissue. We employed next-generation sequencing analyse profiles following groups: (1) hearts were arrested antegrade warm St Thomas Hospital No. 2 (STH2) cardioplegia (n =...
Repeat hospitalizations, complications, and psychosocial burdens are common in patients with left ventricular assist devices (LVAD). Specialist palliative care (sPC) involvement supports during decision-making until end-of-life. In the United States, guidelines recommend early specialist (esPC) prior to implantation. Yet, data about sPC esPC Europe scarce.This is a retrospective descriptive study of deceased LVAD who had received their LVAD-related admissions two university hospitals...
Previous studies demonstrated that preconditioning with argon gas provided a marked reduction in inflammation and apoptosis increased myocardial contractility the setting of acute ischaemia-reperfusion (IR). There is substantial evidence IR injury following cardioplegic arrest associated enhancement inflammation, which considered to play role cardiac functional impairment. Therefore, present study was designed clarify whether enhances recovery function arrest.Sprague-Dawley rats were...
Stem cell therapy for acute myocardial infarction (AMI) seemed to be a promising therapy, however, large clinical trials brought differential outcome. It has been shown that paracrine effects of secretomes stem cells rather than might play fundamental role. The present study seeks compare processing protocols and investigate culture conditions on chemokine secretion functional effects. Different are compared regarding IL-8, VEGF, MCP-1, TNF-alpha secretion. Secretome mediated evaluated...
Worldwide, the left ventricular assist device Impella® (Abiomed, Danvers, MA, USA) is increasingly implanted in patients with acute cardiogenic shock or undergoing high-risk cardiac interventions. Despite its long history of use, few studies have assessed safety and possible complications associated use. All treated a left-sided at University Hospital Basel from 1 January 2011 to 31 December 2019 were enrolled. The primary endpoint was composite rate mortality adverse events (bleeding,...
Abstract Aims The interest in cardiac remodelling (REM) has steadily increased during recent years. aim of this study was to functionally characterize REM following myocardial infarction (MI) mice using high‐end vivo and ex methods. Methods results Myocardial or sham operation induced A/J mice. Six weeks later, underwent magnetic resonance imaging were subsequently sacrificed for measurements on the isolated heart. Thereafter, hearts trichrome stained size calculation. Magnetic showed...
The therapeutic potential of mesenchymal stromal/stem cells (MSC) for treating cardiac ischemia strongly depends on their paracrine-mediated effects and engraftment capacity in a hostile environment such as the infarcted myocardium. Adipose tissue-derived stromal vascular fraction (SVF) are mixed population composed mainly MSC cells, well known high angiogenic potential. A previous study showed that SVF was further increased following vitro organization an engineered tissue (patch) after...
Abstract OBJECTIVES Up-regulation of tenascin C (TNC), a matricellular protein, produced mainly by vascular smooth muscle cells (VSMC), is associated with the progression and dilation abdominal aortic aneurysms (AAA). The aims this study were (i) to evaluate whether serum levels TNC in patients AAA correlate diameter (ii) clarify role formation murine model. METHODS In 15 measured correlated diameters. Moreover, calcium chloride model, impact deficiency on was evaluated. Finally, human VSMC...