A5043434887- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Advanced Radiotherapy Techniques
- Appendicitis Diagnosis and Management
- Hepatitis C virus research
- Intraperitoneal and Appendiceal Malignancies
- Hepatitis B Virus Studies
- Protease and Inhibitor Mechanisms
- Medical Imaging Techniques and Applications
- Infectious Diseases and Tuberculosis
- Hematological disorders and diagnostics
- Cancer survivorship and care
- Radiation Dose and Imaging
- Neuropeptides and Animal Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Palliative Care and End-of-Life Issues
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intestinal Malrotation and Obstruction Disorders
- Healthcare Operations and Scheduling Optimization
- Scheduling and Timetabling Solutions
- Artificial Intelligence in Healthcare
- Hepatitis Viruses Studies and Epidemiology
Medical University of Vienna
2025
Hospital Regional de Alta Especialidad del Bajío
2024
Neurological Surgery
2024
Intelligent Automation (United States)
2021-2022
Pfizer (United States)
2019
Hospital Universitario Virgen del Rocío
2018
Northwestern University
2016-2017
Navarro College
2016
Northwestern Medicine
2016
National University of the Northeast
2008
Neutral endopeptidase 24.11 (NEP, CD10) is a cell-surface enzyme expressed by prostatic epithelial cells that cleaves and inactivates neuropeptides implicated in the growth of androgen-independent prostate cancer (PC). NEP substrates such as bombesin endothelin-1 induce cell migration. We investigated mechanisms regulation migration PC cells, including phosphorylation on tyrosine focal adhesion kinase (FAK). Western analyses assays revealed an inverse correlation between expression levels...
Aim of this study was to investigate how different indices express aortic stiffness can be understood and what the impact loading conditions is. Thoracic aortas from swine (n = 6) sheep were tested in a pulsatile mock circulation loop. Aortas loaded at constant heart rate stroke volume increasing diastolic pressure with pulse 40 mmHg 60/20 180/140 20 steps. Data analyzed using commonly used formulas calculate absolute strain, dynamic circumferential compliance, distensibility, wave velocity,...
Neutral endopeptidase 24.11 (NEP) is a cell surface peptidase expressed by numerous tissues including prostatic epithelial cells. We reported that NEP inhibits prostate cancer proliferation and migration enzymatic inactivation of neuropeptide substrates through protein-protein interaction independent catalytic function. The cytoplasmic domain contains positively charged amino acid cluster, previously identified as binding site for ezrin/radixin/moesin (ERM) proteins. report here...
Neutral endopeptidase (NEP) is a cell-surface peptidase that can regulate the activation of Akt kinase through catalytic-dependent and independent mechanisms. NEP expression absent in approximately 50% prostate cancers. The authors investigated whether loss vivo would result phosphorylation potentially contribute to cancer progression by examining interaction NEP, Akt, phosphatase tensin homolog (PTEN) xenograft model clinical specimens from patients with cancer.Using...
Intradural extramedullary bronchogenic cysts (IEBCs) are exceedingly rare congenital entities, composed of respiratory epithelial cells derived from the anomalous development embryonic foregut. Due to their exceptionally low morbidity, only limited cases available. Consequently, clinical features and optimal therapeutic approach remain poorly understood. We report a very unusual case 54-year-old Mexican male who initially presented with paraparesis seven years ago, leading significant gait...
A prospective nonrandomized study investigating the accuracy and utility of autologous leukocyte scanning in diagnosis apendicitis was performed. One hundred patients whom clinical appendicitis uncertain underwent indium 111 oxyquinoline labelling leukocytes 2 hours following reinjection. Of 32 with proved appendicitis, three scans revealed normal results (false-negative rate, 0.09). 68 without had positive (false-positive 0.03; sensitivity, 0.91; specificity, 0.97; predictive value scan,...
Accurate self-reported symptomatic toxicity documentation via the Patient-Reported Outcomes version of Common Terminology Criteria for Adverse Events (PRO-CTCAE) is essential throughout cancer treatment to ensure safety and understand therapeutic efficacy. However, capture accurate toxicities from patients undergoing radiation therapy challenging because this generally provided only at time scheduled visits.This study seeks establish usability feasibility a mobile PRO-CTCAE Administration...
Background: Multidisciplinary transitional care teams represent a model for reducing heart failure readmissions. Within this context, early identification of patients hospitalized with acute decompensated (ADHF) permits meaningful plan development. Improving the efficiency higher risk ADHF patient represents an area not well studied in (HF). Objective: To validate sensitivity and specificity enterprise data warehouse (EDW)-based strategy ADHF. Methods: An EDW query was constructed to...
Background: Heart failure (HF) readmissions remain a major driver of cost and health care utilization. Timely follow-up patients post-discharge represents an evidence-based intervention proven to reduce readmission rates. A previously unexplored characteristic hospital discharges is variability in discharge caseload. This thwarts the timeliness follow-up, negates benefit transition planning may lead higher risk HF readmissions. Queuing theory mathematical study waiting times. We opted use...
Background: Small field sizes used for stereotactic radiosurgery shouldn’t require the use of large unwieldy three-dimensional water tanks commissioning. A study was undertaken to determine whether a smaller volume generates significant scatter radiation yield beam data measurements similar those obtained using full-sized tank. In addition, light, small tank, would allow movement whole tank in space so that direct SAD can be much shorter time. Methods: novel new idea scanner design developed...