A5084361989- Mechanical Circulatory Support Devices
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Failure Treatment and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac and Coronary Surgery Techniques
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Intramuscular injections and effects
- Cardiac Valve Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Optical Imaging and Spectroscopy Techniques
- Cardiac Ischemia and Reperfusion
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hemophilia Treatment and Research
- Magnesium in Health and Disease
- Epilepsy research and treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Atrial Fibrillation Management and Outcomes
- Immune Response and Inflammation
- Antiplatelet Therapy and Cardiovascular Diseases
- IL-33, ST2, and ILC Pathways
- Intensive Care Unit Cognitive Disorders
- Neurological Disorders and Treatments
Medical University of Vienna
2013-2022
Vienna General Hospital
2019
Barro Colorado Island
2018
University of Rome Tor Vergata
2006
Systemic blood flow in patients on extracorporeal assist devices is frequently not or only minimally pulsatile. Loss of pulsatile brain perfusion, however, has been implicated neurological complications. Furthermore, the adverse effects absent pulsatility cerebral microcirculation are modulated similarly as CO2 vasoreactivity resistance vessels. During support with an device swings arterial carbon dioxide partial pressures (PaCO2) that determine oxygen delivery uncommon-especially when...
Summary Reparixin, a CXCR 1/2 antagonist, has been shown to mitigate ischaemia–reperfusion injury (IRI) in various organ systems animals, but data humans are scarce. The aim of this double-blinded, placebo-controlled pilot study was evaluate the safety and efficacy reparixin suppress IRI inflammation patients undergoing on-pump coronary artery bypass grafting (CABG). Patients received either or placebo (n = 16 each group) after induction anaesthesia until 8 h cardiopulmonary (CPB). We...
The high shear rates induced by left ventricular assist devices cause acquired von Willebrand disease (aVWD). We hypothesised that an ex vivo model could be established to study whether mechanical stress alone causes aVWD or this process depends also on the VWF cleavage protein ADAMTS-13 and platelets.Healthy volunteers two patients with congenital deficiency donated blood. In vitro closed extracorporeal circuits were using medically approved (LVAD). multimers quantified gel electrophoresis;...
The prognostic impact of thrombocytopenia in patients supported by extracorporeal membrane oxygenation after cardiac surgery is uncertain. We investigated whether independently predictive poor outcome and describe the incidence time course patients.Retrospective analysis prospectively collected data.Cardiosurgical ICU at a tertiary referral center.Three hundred adult with venoarterial for more than 24 hours because refractory cardiogenic shock heart between January 2001 December...
The use of left ventricular assist device (LVAD) has increased considerably over the past decade; however, there is limited literature to in patient selection and monitoring. frequency adverse events remains high. We examined early expression circulating soluble ST2 (sST2), a biomarker with immunosuppressive profibrotic activity, assessed risk death at 1 year patients receiving LVAD implant.We prospectively enrolled 20 heart failure measured sST2, IL-33, IL-6 serum concentrations three weeks...
Abstract OBJECTIVES Although extracorporeal membrane oxygenation (ECMO) represents a rapidly evolving treatment option in patients with refractory heart or lung failure, survival remains poor and appropriate risk stratification challenging because established prediction models have not been validated for this specific population. METHODS This observational single-centre registry included total of 240 treated venoarterial ECMO therapy following cardiovascular surgery analysed the...
Heart failure patients are frequently on coagulation-active medications before LVAD implantation and perioperative bleeding is a frequent complication after left ventricular assist device (LVAD) implantation. The role of point-of-care coagulation tests in assessing risk for the early postoperative time course these not well established.We prospectively enrolled 25 with terminal heart undergoing Study related TRAP-, ASPI- ADP- Multiplate® platelet aggregometry, ROTEM® rotational...
We studied the neuroprotective effect of magnesium sulphate (MgSO4) administered before ventricular fibrillation was induced for internal cardioverter defibrillator threshold testing, and continued during reperfusion. With intention increasing serum (Mg) to >1.2 mmol/L, 15 patients received 16 mmol MgSO4, IV, followed by 5 over two hours. Fifteen placebo. Serum neuron-specific enolase (NSE) assessed, as well pre- postoperative neurocognitive function. NSE increased in all patients, reaching...
Neurological complications after heart surgery are associated with tremendous morbidity and mortality. Nonconvulsive status epilepticus (NCSE), which can only be verified by EEG, may cause secondary brain damage. Its frequency its impact on outcomes cardiac is still unclear. We collected the neurological files clinical data of all our patients who, in course their ICU stay, had been seen a neurologist who ordered an EEG. Within 18 months, 1457 cardiopulmonary bypass. EEG was requested for 89...
Abstract Background Neonates and small infants with congenital cardiac disease undergoing surgery represent major challenges facing paediatric anaesthesia perioperative medicine. Aims. We here aimed to investigate the success rates in performing ultrasound (US) guided central venous catheter insertion (CVC) neonates surgery, evaluate practicability feasibility of thereby using a novel wireless US transducer (WUST). Methods Thirty maximum body weight 10 kg need for CVC before were included...
Regional cerebral tissue saturation monitoring is frequently used in patients on mechanical cardiac assist devices with the intention to promptly detect critical imbalances between oxygen delivery and extraction ultimately circumvent permanent brain injury. We report a case where an intraparenchymal bleed supply zone of middle artery—followed by severe hemispherical edema, leading life-threatening intracranial hypertension—escaped oximetry using near-infrared spectroscopy. Potential...
Objectives: Heparin-induced thrombocytopenia type II (HIT) is an antibody-mediated adverse drug reaction that can lead to devastating thromboembolic complications. The highest incidence of HIT (7 – 10%) among cardiac surgery patients described in with a assist device receiving UFH.
Mora, B.; Schiferer, A.; Mouhieddine, M.; Giorni, E.; Felli, Grimm, Hiesmayr, M. Author Information
Tenze, G.; Klingbacher, E.; Felli, A.; Mares, P.; Sabato, A. F.; Lassnigg, Hiesmayr, M.Author Information
Effects of a Protein Optimized Diet Combined with Moderate Resistance Training on the Postoperative Course in Older Patients Hip Fracture