A5000814967- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Mechanisms of cancer metastasis
- Gastrointestinal Tumor Research and Treatment
- Chemical Reactions and Isotopes
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Metastasis and carcinoma case studies
- Click Chemistry and Applications
- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Lung Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Meningioma and schwannoma management
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2015-2024
University of Vienna
2012-2023
Vienna General Hospital
2015-2021
Music and Arts University of the City of Vienna
2019
German Cancer Research Center
2016
Heidelberg University
2016
Abstract Trastuzumab deruxtecan is an antibody–drug conjugate with high extracranial activity in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. We conducted the prospective, open-label, single-arm, phase TUXEDO-1 trial. enrolled patients aged ≥18 years HER2-positive cancer and newly diagnosed untreated brain metastases or progressing after previous local therapy, exposure to trastuzumab pertuzumab no indication for immediate therapy. Patients received...
Brain metastases (BM) are a devastating complication of HER2-positive metastatic breast cancer (BC) and treatment strategies providing optimized local systemic disease control urgently required. The antibody-drug conjugate trastuzumab deruxtecan (T-DXd) improved progression-free survival (PFS) overall (OS) over emtansine but data regarding intracranial activity is limited. In the primary outcome analysis TUXEDO-1, high response rate (RR) was reported with T-DXd. Here, we report final PFS OS results.
The aim of this study was to determine the clinical role systemic immune-inflammation index in patients with resectable adenocarcinoma gastroesophageal junction treated or without neoadjuvant therapy.Adenocarcinoma is an aggressive disease, less than 20% overall surviving more 5 years after diagnosis, while currently available staging for esophageal cancer lacking necessary accuracy. (SII) based on peripheral neutrophil, lymphocyte, and platelet counts has shown a prognostic impact various...
Patients with nonsquamous non-small cell lung cancer (nsNSCLC; largely adenocarcinoma) are at high risk of developing brain metastases. Preclinical data suggested that anti-VEGF-A therapy may prevent the formation nsNSCLC Whether non-brain metastases also prevented, and whether bevacizumab shows a metastases-preventive activity in patients is unknown. Data one (stage IIIB/IV, AVAiL) two breast trials (HER2 negative, AVADO; HER2 positive, AVEREL) were retrospectively analyzed regarding...
Background: MicroRNAs are proposed as plasma biomarkers in cancer. Glioblastoma is the most frequent primary brain tumor of adults. MicroRNA-21 was shown to induce glioblastoma growth. Aims: To evaluate circulating microRNA-21 patients. Methods: copies (n = 10, before surgery and during/after concomitant chemoradiotherapy), control 10), tissue samples were analyzed using RT-qPCR. Results: significantly higher than controls (p .02) decreased 9 patients .05). One patient with increasing...
We aimed to characterize angiogenesis and proliferation their correlation with clinical characteristics in a large brain metastasis (BM) series.Ki67 index, microvascular density (MVD) hypoxia-inducible factor 1 alpha (HIF-1 alpha) index were determined by immunohistochemistry BM primary tumour specimens.Six hundred thirty-nine specimens of 639 patients lung cancer (344/639; 53.8%), breast (105/639; 16.4%), melanoma (67/639; 10.5%), renal cell carcinoma (RCC; 52/639; 8.1%) or colorectal (CRC;...
Summary This article aims to summarize the highlights of two largest global congresses 2024 with respect gastroesophageal tumors. The triplet chemotherapy combination known as FLOT (5-fluorouracil, leucovorin, oxaliplatin, docetaxel), used perioperative chemotherapy, was demonstrated improve overall and disease-free survival in resectable cancer patients some time ago. Despite being standard for this patient population, many questions different scenarios remain open: Is also efficacious...
HighlightsAdvanced imaging detects more asymptomatic metastatic esophagogastric cancerThis Delphi study explores optimal timing of initiating treatment in these patientsImmediate start is mostly preferred by European expertsConsensus was to defer older or WHO 2 patients who prefer deferralAbstractBackgroundThe enhanced application techniques resulting the diagnosis with cancer (mEGC). We conducted a gather insights from experts on palliative systemic therapy for patients.MethodsAn online...
Brain metastases (BM) are the most common brain tumors of adults and associated with fatal prognosis. Formation new blood vessels, named angiogenesis, was proposed to be main hallmark growth BM. Previous preclinical evidence revealed that angiogenic blockage might considered for treatment; however, there were varying responses. In this study, we aimed characterize expression pattern angiogenesis-related genes in BM lung cancer melanoma, which importance different responses against...
Background MRI-based diffusion-weighted imaging (DWI) visualizes the local differences in water diffusion vivo. The prognostic value of DWI signal intensities on source images and apparent coefficient (ADC) maps respectively has not yet been studied brain metastases (BM). Methods We included into this retrospective analysis all patients operated for single BM at our institution between 2002 2010, whom presurgical tissue samples were available. recorded relevant clinical data, assessed...
Acute kidney injury is frequently observed at the intensive care unit, after surgery, and toxic drug administration. A rise in serum creatinine a fall urine output are consequences of much earlier to most sensitive part tubular cells located proximal tubule. The aim present study was investigate course two cell-cycle arrest urinary biomarkers compared four clinical settings: ischemic reperfusion injury, cardiac failure, severe acute chemotherapy-induced injury. recently developed bedside...
// Gerd Jomrich 1 , Marlene Hollenstein Maximilian John Andreas Baierl 2 Matthias Paireder Ivan Kristo Aysegül Ilhan-Mutlu 3 Reza Asari Preusser and Sebastian F. Schoppmann Department of Surgery, Medical University Vienna, Gastroesophageal Tumor Unit, Comprehensive Cancer Center (CCC), 1090 Austria Statistics Operations Research, Medicine 1, Correspondence to: Schoppmann, email: sebastian.schoppmann@meduniwien.ac.at Keywords: adenocarcinoma the esophagogastric junction; neoadjuvant...
Pulmonary arterial hypertension is a severe and progressive disease characterized by pulmonary vascular remodeling process with expansion of collateral endothelial cells total vessel occlusion. Endothelial are believed to be at the forefront process. Vascular growth factor (VEGF) its tyrosine kinase receptor, VEGF receptor-2 (VEGFR-2), play central role in angiogenesis, cell protection, but also destabilization barrier function. Therefore, we investigated consequences altered signaling an...
Abstract Specific biological properties of those circulating cancer cells that are the origin brain metastases (BM) not well understood. Here, single breast were fate-tracked during all steps metastatic cascade in mice after intracardial injection over weeks. A novel vivo two-photon microscopy methodology was developed allowed to determine specific cellular and molecular features homed brain, extravasated, successfully established a macrometastasis. Those BM-initiating (BMIC) mainly...