A5084128717- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Infective Endocarditis Diagnosis and Management
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Hemodynamic Monitoring and Therapy
- Cardiac tumors and thrombi
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Issues in Pregnancy
- Nitric Oxide and Endothelin Effects
- Blood Coagulation and Thrombosis Mechanisms
- Mechanical Circulatory Support Devices
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Pleural and Pulmonary Diseases
Medical University of Vienna
2015-2024
Arbeitsgemeinschaft für Klinische Ernährung
2023
Evangelisches Krankenhaus Bielefeld
2021
University of Münster
2021
Centrum für Integrierte Onkologie
2021
University Hospital Cologne
2021
Santa Maria Nuova Hospital
2020
Maastricht University
2020
Vienna General Hospital
2013-2019
Justus-Liebig-Universität Gießen
2014
Rationale: Mechanisms of coronary occlusion in ST-elevation acute syndrome are poorly understood. We have previously reported that neutrophil (polymorphonuclear cells [PMNs]) accumulation culprit lesion site (CLS) thrombus is a predictor cardiovascular outcomes. Objective: The goal this study was to characterize PMN activation at the CLS. examined relationships between CLS extracellular traps (NETs), bacterial components as triggers NETosis, activity endogenous deoxyribonuclease, ST-segment...
Objective— Restoration of patency is a natural target vascular remodeling after venous thrombosis that involves endothelial cells and smooth muscle cells, as well leukocytes. Acute pulmonary emboli usually resolve <6 months. However, in some instances, thrombi transform into fibrous obstructions, resulting occlusion the deep veins, or chronic thromboembolic hypertension (CTEPH). We proposed dysregulated thrombus angiogenesis may contribute to persistence. Approach Results— Mice with an...
Abstract Aims Concomitant cardiac amyloidosis (CA) in severe aortic stenosis (AS) is difficult to recognize, since both conditions are associated with concentric left ventricular thickening. We aimed assess type, frequency, screening parameters, and prognostic implications of CA AS. Methods results A total 191 consecutive AS patients (81.2 ± 7.4 years; 50.3% female) scheduled for transcatheter valve replacement (TAVR) were prospectively enrolled. Overall, 81.7% underwent complete assessment...
Background Splenectomy is a clinical risk factor for complicated thrombosis. We hypothesized that the loss of mechanical filtering function spleen may enrich thrombogenic phospholipids in circulation, thereby affecting vascular remodeling Methods and Results investigated effects splenectomy both chronic thromboembolic pulmonary hypertension ( CTEPH ), human model disease thrombus nonresolution, mouse stagnant flow venous thrombosis mimicking deep vein Surgically excised thrombi from rare...
Tricuspid regurgitation secondary to heart failure (HF) is common with considerable impact on survival and hospitalization rates. Currently, insights into epidemiology, impact, treatment of tricuspid (sTR) across the entire HF spectrum are lacking, yet necessary for healthcare decision-making.
To investigate the clinical utility of pretreatment plasma fibrinogen levels in malignant pleural mesothelioma (MPM) patients. A retrospective multicenter study was performed histologically proven MPM All were measured at time diagnosis and data retrospectively collected after approval corresponding ethics committees. In total, 176 patients (mean age: 63.5 years±10.4 years, 38 females 138 males) analysed. Most (n=154, 87.5%) had elevated (⩾390 mg dl−1) levels. When grouped by median...
Recent evidence suggested levels of aspartate aminotransferase (AST), alanine transaminase (ALT), and AST/ALT ratio (De-Ritis ratio) were associated with a worse outcome after acute myocardial infarction (AMI). However, their value for predicting long-term prognosis remained unknown. Therefore, we investigated the prognostic potential transaminases on patient AMI from perspective.Data large registry including 1355 consecutive patients analyzed. The Cox regression hazard analysis was used to...
The interleukin-6 (IL-6) pathway has a crucial role in the pathogenesis of atherosclerosis, main cause cardiovascular diseases. We aimed to characterize predictive value inflammatory biomarkers on long-term mortality patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI). This prospective observational study included 322 consecutive ACS PCI. Blood-derived IL-6 and high-sensitivity C-reactive protein (hsCRP) were assessed at time point ACS. Patients followed-up...
Abstract Background Guideline-directed medical therapy (GDMT) is the recommended initial treatment for secondary mitral regurgitation (SMR), however, supported by only little comprehensive evidence. This study, therefore, sought to assess effect of GDMT titration on SMR and identify specific substance combinations able reduce severity. Methods results We included 261 patients who completed two visits with an echocardiographic exam available within 1 month at each visit. After comprehensively...
Background: Dual pathology of severe aortic stenosis (AS) and transthyretin cardiac amyloidosis (ATTR) is increasingly recognized. Evolution symptoms, biomarkers, myocardial mechanics in AS-ATTR following valve replacement unknown. We aimed to characterize reverse remodeling compared with lone AS. Methods: Consecutive patients referred for transcatheter (TAVR) underwent ATTR screening by blinded 99mTc-DPD bone scintigraphy (Perugini Grade-0 negative, 1–3 positive) before intervention. was...
To evaluate the prognostic and predictive relevance of pretreatment serum C-reactive protein (CRP) in malignant pleural mesothelioma (MPM) patients.MPM is a rare but aggressive disease with poor treatment outcome. Therapeutic decision challenging, biomarkers for better stratification are urgently needed.Clinical data, including survival CRP levels, were retrospectively collected from 115 patients histologically proven MPM. Patients any evidence infectious excluded. The association between...
Atrial fibrillation (AF) represents the most common cardiac arrhythmia. Especially in patients with chronic heart failure (CHF) development of AF a severe complication resulting haemodynamic deterioration. While pro-inflammatory cytokines proved to have pivotal role and progression both CHF, less attention has been paid cellular immunity. Therefore we prospectively enrolled 112 CHF performed fluorescein-activated cell sorting (FACS). Patients were stratified two subgroups according...
The aim of the present study was to investigate patterns platelet reactivity and discriminators therapeutic response dual antiplatelet therapy (DAPT) with aspirin ticagrelor or prasugrel in patients acute coronary syndrome (ACS).
Pulmonary arterial hypertension is a severe and progressive disease characterized by pulmonary vascular remodeling process with expansion of collateral endothelial cells total vessel occlusion. Endothelial are believed to be at the forefront process. Vascular growth factor (VEGF) its tyrosine kinase receptor, VEGF receptor-2 (VEGFR-2), play central role in angiogenesis, cell protection, but also destabilization barrier function. Therefore, we investigated consequences altered signaling an...
Risk stratification in patients undergoing extracorporeal membrane oxygenation (ECMO) support after cardiovascular surgery remains challenging, because data on specific outcome predictors are limited. Serum butyrylcholinesterase demonstrated a strong inverse association with all-cause and mortality non-critically ill patients. We therefore evaluated the predictive value of preoperative serum levels venoarterial ECMO surgery. prospectively included 191 therapy at university-affiliated...
Recent data suggest that acute coronary syndromes (ACS) and myocardial infarction (AMI) are characterized by an inflammatory subset of thrombosis. We have previously described the accumulation neutrophils at culprit lesion site. In this work, we assessed prognostic value site (CS) neutrophil on long-term mortality in patients with AMI.In prospective study, 417 AMI were enrolled after thrombectomy during primary percutaneous intervention. The optimal cut-off for CS predicting 4-year all-cause...
Abstract Background Inflammatory responses are pivotal in the initiation and development of premature atherosclerotic lesions. Galectin‐3 represents a valuable biomarker for both progression destabilization This study aims to assess involvement galectin‐3 myocardial infarction. Design In this multicentre case–control study, we assessed circulating levels 144 patients comprising 72 consecutive survivors acute infarction (≤ 40 years) hospital controls frequency matched age, gender centre....